Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 7, 2012, Pages 2364-2369

  Ng, Ashley P ^a   Kauppi, Maria ^a   Metcalf, Donald ^a,b   Rago, Ladina Di ^a   Hyland, Craig D ^a   Alexander, Warren S ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD150 ANTIGEN; CD9 ANTIGEN; ENDOGLIN; FC RECEPTOR; FIBRINOGEN RECEPTOR; FLT3 LIGAND; INTERLEUKIN 7 RECEPTOR ALPHA; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL SURFACE; COLONY FORMING UNIT; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; GRANULOCYTE; HEMATOPOIETIC STEM CELL; MACROPHAGE; MEGAKARYOCYTE; MEGAKARYOCYTE ERYTHROID PROGENITOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTOPENIA;

ANIMALS; ANTIGENS, CD; BONE MARROW CELLS; ERYTHROCYTES; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; STEM CELLS; THROMBOPOIETIN;

EID: 84857125323     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121385109     Document Type: Article

References (14)

1. Metcalf D (2010) The colony-stimulating factors and cancer. Nat Rev Cancer 10:425-434.
2. Bradley TR, Metcalf D (1966) The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 44:287-299.
3. Spangrude GJ, Heimfeld S, Weissman IL (1988) Purification and characterization of mouse hematopoietic stem cells. Science 241:58-62.
4. Okada S, et al. (1992) In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 80:3044-3050. (Pubitemid 23004507)
5. Metcalf D, et al. (2009) Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles. Proc Natl Acad Sci USA 106:19102-19107.
6. Akashi K, Traver D, Miyamoto T, Weissman IL (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404:193-197. (Pubitemid 30154488)
7. Nutt SL, Metcalf D, D'Amico A, Polli M, Wu L (2005) Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med 201:221-231. (Pubitemid 40189431)
8. Rieger MA, Smejkal BM, Schroeder T (2009) Improved prospective identification of megakaryocyte-erythrocyte progenitor cells. Br J Haematol 144:448-451.
9. Pronk CJ, et al. (2007) Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell 1:428-442. (Pubitemid 47506534)
10. Nakorn TN, Miyamoto T, Weissman IL (2003) Characterization of mouse clonogenic megakaryocyte progenitors. Proc Natl Acad Sci USA 100:205-210. (Pubitemid 36078053)
11. Tronik-Le Roux D, Roullot V, Schweitzer A, Berthier R, Marguerie G (1995) Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter. J Exp Med 181:2141-2151.
12. Schaefer BC, Schaefer ML, Kappler JW, Marrack P, Kedl RM (2001) Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo. Cell Immunol 214:110-122. (Pubitemid 34499465)
13. de Graaf CA, et al. (2010) Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci USA 107:21689-21694.
14. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D (1996) Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87:2162-2170.