A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae

Metabolic Engineering

Volumn 39, Issue , 2017, Pages 209-219

  Peng, Bingyin ^a   Plan, Manuel R ^a   Chrysanthopoulos, Panagiotis ^a   Hodson, Mark P ^a   Nielsen, Lars K ^a   Vickers, Claudia E ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Endoplasmic reticulum associated protein degradation (ERAD); Metabolic engineering; Saccharomyces cerevisiae; Sesquiterpene; Trans nerolidol

Indexed keywords

ALCOHOLS; CELL MEMBRANES; LIPIDS; METABOLISM; OLEFINS; PROTEINS; YEAST;

ENDOPLASMIC RETICULUM; ENGINEERING APPLICATIONS; FARNESYL PYROPHOSPHATES; MICROBIAL FERMENTATION; NEROLIDOL; PROTEIN DEGRADATION; SESQUITERPENES; YEAST SACCHAROMYCES CEREVISIAE;

METABOLIC ENGINEERING;

ASPARTIC ACID; CARBON; ERGOSTEROL; FARNESYL DIPHOSPHATE; FAT DROPLET; GLUTAMIC ACID; MEVALONIC ACID; NEROLIDOL; PROLINE; SERINE; SESQUITERPENE; SIGNAL PEPTIDE; SQUALENE SYNTHASE; STEROL; THREONINE; ERG9 PROTEIN, S CEREVISIAE; ISOPRENOID PHOSPHATE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; BIOMASS; CARBON ALLOCATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME STABILITY; FUNGAL STRAIN; FUNGUS GROWTH; GENE OVEREXPRESSION; GROWTH RATE; METABOLIC ENGINEERING; NONHUMAN; PLASMID; PRECURSOR; PRIORITY JOURNAL; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STEROL SYNTHESIS; BIOSYNTHESIS; ENZYME ACTIVATION; GENETIC ENHANCEMENT; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PROCEDURES;

BIOSYNTHETIC PATHWAYS; ENZYME ACTIVATION; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; GENETIC ENHANCEMENT; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; POLYISOPRENYL PHOSPHATES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SESQUITERPENES;

EID: 85008145461     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.12.003     Document Type: Article

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