2′-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression

International Journal of Oncology

Volumn 50, Issue 1, 2017, Pages 283-289

  Nguyen, Hai Anh ^a   Kim, Soo A ^a  

^a Dongguk University   (South Korea)

Author keywords

2 hydroxycinnamaldehyde; Apoptosis; BAG3; Cinnamaldehyde; HSF1; Stress

Indexed keywords

2' HYDROXYCINNAMALDEHYDE; CASPASE 7; CASPASE 9; CHAPERONE; CINNAMALDEHYDE DERIVATIVE; HEAT SHOCK TRANSCRIPTION FACTOR 1; LIPOCORTIN 5; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAG3; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAG3 PROTEIN, HUMAN; CINNAMIC ACID DERIVATIVE; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; P-HYDROXYCINNAMALDEHYDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL LINE; CANCER INHIBITION; COLON CANCER; DRUG TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; COLONIC NEOPLASMS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; PATHOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CINNAMATES; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 85007614220     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3790     Document Type: Article

References (34)

1. Parsell DA and Lindquist S: The function of heat-shock proteins in stress tolerance: Degradation and reactivation of damaged proteins. Annu Rev Genet 27: 437-496, 1993.
2. Kaufman RJ: Molecular chaperones and the heat shock response. Sponsored by Cold Spring Harbor Laboratory, 6-10 May 1998. Biochim Biophys Acta 1423: R13-R27, 1999.
3. Morimoto RI: Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, Molecular chaperones, And negative regulators. Genes Dev 12: 3788-3796, 1998.
4. Pirkkala L, Nykänen P and Sistonen L: Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15: 1118-1131, 2001.
5. Kabbage M and Dickman MB: The BAG proteins: A ubiquitous family of chaperone regulators. Cell Mol Life Sci 65: 1390-1402, 2008.
6. Rosati A, Graziano V, De Laurenzi V, Pascale M and Turco MC: BAG3: A multifaceted protein that regulates major cell pathways. Cell Death Dis 2: e141, 2011.
7. Doong H, Price J, Kim YS, Gasbarre C, Probst J, Liotta LA, Blanchette J, Rizzo K and Kohn E: CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. oncogene 19: 4385-4395, 2000.
8. McCollum AK, Casagrande G and Kohn EC: Caught in the middle: The role of Bag3 in disease. Biochem J 425: e1-e3, 2009.
9. Shi H, Xu H, Li Z, Zhen Y, Wang B, Huo S, Xiao R and xu Z: BAG3 regulates cell proliferation, Migration, And invasion in human colorectal cancer. Tumour Biol 37: 5591-5597, 2016.
10. Suzuki M, Iwasaki M, Sugio A, Hishiya A, Tanaka R, Endo T, Takayama S and Saito T: BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells. Cancer Lett 303: 65-71, 2011.
11. Behl C: BAG3 and friends: Co-chaperones in selective autophagy during aging and disease. Autophagy 7: 795-798, 2011.
12. Pagliuca MG, Lerose R, Cigliano S and Leone A: Regulation by heavy metals and temperature of the human BAG-3 gene, A modulator of Hsp70 activity. FEBS Lett 541: 11-15, 2003.
13. Rosati A, Di Salle E, Luberto L, Quinto I, Scala G, Turco MC and Pascale M: Identifcation of a Btk-BAG3 complex induced by oxidative stress. Leukemia 23: 823-824, 2009.
14. Rosati A, Leone A, Del Valle L, Amini S, Khalili K and Turco MC: Evidence for BAG3 modulation of HIV-1 gene transcription. J Cell Physiol 210: 676-683, 2007.
15. Franceschelli S, Rosati A, Lerose R, De Nicola S, Turco MC and Pascale M: Bag3 gene expression is regulated by heat shock factor 1. J Cell Physiol 215: 575-577, 2008.
16. Jin YH, Ahn SG and Kim SA: BAG3 affects the nucleocyto-plasmic shuttling of HSF1 upon heat stress. Biochem Biophys Res Commun 464: 561-567, 2015.
17. Festa M, Del Valle L, Khalili K, Franco R, Scognamiglio G, Graziano V, De Laurenzi V, Turco MC and Rosati A: BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Am J Pathol 178: 2504-2512, 2011.
18. Zhu H, Wu W, Fu Y, Shen W, Miao K, Hong M, Xu W, Young KH, Liu P and Li J: Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia. Ann Hematol 93: 425-435, 2014.
19. Ammirante M, De Laurenzi V, Graziano V, Turco MC and Rosati A: BAG3 is required for IKKα nuclear translocation and emergence of castration resistant prostate cancer. Cell Death Dis 2: e139, 2011.
20. Liao Q, Ozawa F, Friess H, Zimmermann A, Takayama S, Reed JC, Kleeff J and Büchler MW: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Lett 503: 151-157, 2001.
21. Shen Y, Jia LN, Honma N, Hosono T, Ariga T and Seki T: Beneficial effects of cinnamon on the metabolic syndrome, Inflammation, And pain, And mechanisms underlying these effects-a review. J Tradit Complement Med 2: 27-32, 2012.
22. Kwon JA, Yu CB and Park HD: Bacteriocidal effects and inhibition of cell separation of cinnamic aldehyde on Bacillus cereus. Lett Appl Microbiol 37: 61-65, 2003.
23. Cheng SS, Liu JY, Chang EH and Chang ST: Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi. Bioresour Technol 99: 5145-5149, 2008.
24. Chao LK, Hua KF, Hsu HY, Cheng SS, Lin IF, Chen CJ, Chen ST and Chang ST: Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling. Food Chem Toxicol 46: 220-231, 2008.
25. Jeong HW, Han DC, Son KH, Han MY, Lim JS, Ha JH, Lee CW, Kim HM, Kim HC and Kwon BM: Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase. Biochem Pharmacol 65: 1343-1350, 2003.
26. Lee SH, Lee CW, Lee JW, Choi MS, Son DJ, Chung YB, Lee CK, Oh KW, Moon DC, Kwon BM, et al: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-α-treated SW620 colon cancer cells. Biochem Pharmacol 70: 1147-1157, 2005.
27. Hong SH, Kim J, Kim JM, Lee SY, Shin DS, Son KH, Han DC, Sung YK and Kwon BM: Apoptosis induction of 2'-hydroxycin-namaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. Biochem Pharmacol 74: 557-565, 2007.
28. Lee CW, Lee SH, Lee J W, Ban JO, Lee SY, Yoo HS, Jung JK, Moon DC, Oh KW and Hong JT: 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inacti-vation. J Pharmacol Sci 104: 19-28, 2007.
29. Kim SA, Sung YK, Kwon BM, Yoon JH, Lee H, Ahn SG and Hong SH: 2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor model. Anticancer Res 30: 489-494, 2010.
30. Ahn SG, Jin YH, Yoon JH and Kim SA: The anticancer mechanism of 2'-hydroxycinnamaldehyde in human head and neck cancer cells. Int J oncol 47: 1793-1800, 2015.
31. Dai C, Whitesell L, Rogers AB and Lindquist S: Heat shock factor 1 is a powerful multifaceted modifer of carcinogenesis. Cell 130: 1005-1018, 2007.
32. Sherman MY and Gabai VL: Hsp70 in cancer: Back to the future. oncogene 34: 4153-4161, 2015.
33. Liu P, Xu B, Li J and Lu H: BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis. FEBS Lett 583: 401-406, 2009.
34. Mani J, Antonietti P, Rakel S, Blaheta R, Bartsch G, Haferkamp A and Kögel D: Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737. World J Urol 34: 197-205, 2016.