2′-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor model

Anticancer Research

Volumn 30, Issue 2, 2010, Pages 489-494

  Kim, Soo A ^a   Sung, Young Kwan ^b   Kwon, Byoung Mog ^c   Yoon, Jung Hoon ^d   Lee, Haeahm ^e   Ahn, Sang Gun ^d   Hong, Su Hyung ^e  

^a Dongguk University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Chosun University   (South Korea)

^e Kyungpook National University   (South Korea)

Author keywords

2 Hydroxycinnamaldehyde; Apoptosis; Cell cycle; Oral cancer; Tumor model

Indexed keywords

2 BENZOYL OXYCINNAMALDEHYDE; 2' HYDROXYCINNAMALDEHYDE; ANTINEOPLASTIC AGENT; CINNAMALDEHYDE DERIVATIVE; UNCLASSIFIED DRUG; CINNAMIC ACID DERIVATIVE; P HYDROXYCINNAMALDEHYDE; P-HYDROXYCINNAMALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUTH CANCER; MOUTH TUMOR; NONHUMAN; PRIORITY JOURNAL; RAT; SQUAMOUS CELL CARCINOMA; TUMOR CELL; ANIMAL; CELL CYCLE; DRUG EFFECT; DRUG SCREENING; ENZYME IMMUNOASSAY; PATHOLOGY; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL PROLIFERATION; CINNAMATES; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MOUTH NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77950531127     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Schoene NW, Kelly MA, Polansky MM and Anderson RA: Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines. Cancer Lett 230: 134-140, 2005.
2. Dhuley JN: Anti-oxidant effects of cinnamon (Cinnamomum verum) bark and greater cardamom (Amomum subulatum) seeds in rats fed high fat diet. Indian J Exp Biol 37: 238-242, 1999.
3. Kwon BM, Cho YK, Lee SH, Nam JY, Bok SH, Chun SK, Kim JA and Lee IR: 2′-Hydroxycinnamaldehyde from stem bark of Cinnamomum cassia. Planta Med 62: 183-184, 1996.
4. Kwon BM, Lee SH, Cho YK, Bok SH, So SH, Youn MR and Chang SI: Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors. Bioorg Med Chem Lett 7: 2473-2476, 1997.
5. 2/M phase. Biochem Pharmacol 65: 1343-1350, 2003.
6. Moon EY, Lee MR, Wang AG, Lee JH, Kim HC, Kim JM, Kwon BM and Yu DY: Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes. Eur J Pharmacol 530: 270-275, 2006.
7. Lee CW, Hong DH, Han SB, Park SH, Kim HK, Kwon BM and Kim HM: Inhibition of human rumor growth by 2′-hydroxy- and 2′- benzoyloxycinnamaldehydes. Planta Med 65: 263-266, 1999.
8. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
9. Reid BC, Winn DM, Morse DE and Pendrys DG: Head and neck in situ carcinoma: incidence, trends, and survival. Oral Oncol 36: 414-420, 2000.
10. Morse DE, Pendrys DG, Neely AL and Psoter WJ: Trends in the incidence of lip, oral, and pharyngeal cancer. Connecticut, 1935-94. Oral Oncol 35: 1-8, 1999.
11. Kim SA, Kim HW, Kim DK, Kim SG, Park JC, Kang DW, Kim SW, Ahn SG and Yoon JH: Rapid induction of malignant tumor in Sprague-Dawley rats by injection of RK3E-ras cells. Cancer Lett 235: 53-59, 2006.
12. Kim SA, Kim YC, Kim SW, Lee SH, Min JJ, Ahn SG and Yoon JH: Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res 13: 253-259, 2007.
13. Hansen MB, Nielsen SE and Berg K: Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119: 203-210, 1989.
14. Carlsson G, Gullberg B and Hafström L: Estimation of liver tumor volume using different formulas - an experimental study in rats. J Cancer Res Clin Oncol 105: 20-23, 1983.
15. Han DC, Lee MY, Shin KD, Jeon SB, Kim JM, Son KH, Kim KC, Kim HM and Kwon BM: 2′-Benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species. J Biol Chem 279: 6911-6920, 2004.
16. Hong SH, Kim J, Kim JM, Lee SY, Shin DS, Son KH, Han DC, Sung YK and Kwon BM: Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. Biochem Pharmacol 74: 557-565, 2007.
17. Lee K, Kwon BM, Kim K, Ryu J, Oh SJ, Lee KS, Kwon MG, Park SK, Kang JS, Lee CW and Kim HM: Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2′-benzoyloxycinnamaldehyde in rats. Xenobiotica 39: 255-265, 2009.
18. 2 tension measurements. Cancer Res 51: 3316-3322, 1991.
19. Cowen RL, Williams KJ, Chinje EC, Jaffar M, Sheppard FC, Telfer BA, Wind NS and Stratford IJ: Hypoxia-targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure. Cancer Res 64: 1396-1402, 2004.
20. Wagenknecht B, Hermisson M, Eitel K and Weller M: Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells. Cell Physiol Biochem 9: 117-125, 1999.
21. Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E and Colomer D: The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and NoXa activation independent of p53 status. Blood 107: 257-264, 2006.