Caught in the middle: The role of Bag3 in disease

Biochemical Journal

Volumn 425, Issue 1, 2010, Pages

  McCollum, Andrea K ^a   Casagrande, Giovanna ^a   Kohn, Elise C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Autophagy; Bag3; Co chaperone; HspB6; HspB8; Muscular dystrophy; Protein degradation

Indexed keywords

BCL2 ASSOCIATED ATHANOGENE 3; BINDING PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 22; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN B6; HUNTINGTIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOLIPASE C GAMMA; UNCLASSIFIED DRUG;

BINDING AFFINITY; EXON; GENE MUTATION; HUMAN; MUSCULAR DYSTROPHY; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AUTOPHAGY; BINDING SITES; CELL LINE; HEAT-SHOCK PROTEINS; HSP20 HEAT-SHOCK PROTEINS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; MUSCULAR DYSTROPHIES; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; TRINUCLEOTIDE REPEATS;

EID: 72449190234     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091739     Document Type: Note

References (10)

1. Doong, H., Vrailas, A. and Kohn, E. C. (2002) What's in the 'BAG'? - A functional domain analysis of the BAG-family proteins. Cancer Lett. 188, 25-32
2. Fuchs, M., Poirier, D. J., Seguin, S., Lambert, H., Carra, S., Charrette, S. J. and Landry, J. (2010) Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem. J. 425, 245-255
3. Doong, H., Price, J., Kim, Y. S., Gasbarre, C., Probst, J., Liotta, L. A., Blanchette, J., Rizzo, K. and Kohn, E. (2000) CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-γ and Hsp70/ Hsc70. Oncogene 19, 4385-4395
4. Gamerdinger, M., Hajieva, P., Kaya, A. M., Wolfrum, U., Hartl, F. U. and Behl, C. (2009) Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J. 28, 889-901
5. Ravikumar, B., Futter, M., Jahreiss, L., Korolchuk, V. I., Lichtenberg, M., Luo, S., Massey, D. C., Menzies, F. M., Narayanan, U., Renna, M. et al. (2009) Mammalian macroautophagy at a glance. J Cell Sci. 122, 1707-1711
6. Carra, S., Seguin, S. J., Lambert, H. and Landry, J. (2008) HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J. Biol. Chem. 283, 1437-1444
7. Youn, D. Y., Lee, D. H., Lim, M. H., Yoon, J. S., Lim, J. H., Jung, S. E., Yeum, C. E., Park, C. W., Youn, H. J., Lee, J. S. et al. (2008) Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus. Am. J. Physiol. Endocrinol. Metab. 295, E1349-E1357
8. Homma, S., Iwasaki, M., Shelton, G. D., Engvall, E., Reed, J. C. and Takayama, S. (2006) BAG3 deficiency results in fulminant myopathy and early lethality. Am. J. Pathol. 169, 761-773
9. Jackson, M. J. (2008) Redox regulation of skeletal muscle. IUBMB Life 60, 497-501
10. Selcen, D., Muntoni, F., Burton, B. K., Pegoraro, E., Sewry, C., Bite, A. V. and Engel, A. G. (2009) Mutation in BAG3 causes severe dominant childhood muscular dystrophy. Ann. Neurol. 65, 83-89