A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies

PLoS Genetics

Volumn 12, Issue 12, 2016, Pages

  Plassais, Jocelyn ^a,b   Lagoutte, Laetitia ^a,b   Correard, Solenne ^a,b   Paradis, Manon ^c   Guaguère, Eric ^d   Hédan, Benoit ^a,b   Pommier, Alix ^a,b   Botherel, Nadine ^a,b   Cadiergues, Marie Christine ^e   Pilorge, Philippe ^d   Silversides, David ^c   Bizot, Maud ^a,b   Samuels, Mark ^f   Arnan, Carme ^g,h,i   Johnson, Rory ^g,h,i   Hitte, Christophe ^a,b   Salbert, Gilles ^a,b   Méreau, Agnès ^a,b   Quignon, Pascale ^a,b   Derrien, Thomas ^a,b   André, Catherine ^a,b   more..

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d CLINIQUE VÉTÉRINAIRE   (France)

^e UNIVERSITÉ DE TOULOUSE   (France)

^f UNIVERSITY OF MONTREAL   (Canada)

^g CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^h UNIVERSITAT POMPEU FABRA   (Spain)

ⁱ HOSPITAL DEL MAR   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LONG UNTRANSLATED RNA; MESSENGER RNA;

ANALGESIA (SENSORY DYSFUNCTION); ANIMAL TISSUE; ARTICLE; AUTOMUTILATION; CHROMOSOME 4; CONTROLLED STUDY; DOG BREED; ENHANCER REGION; GDNF GENE; GEL MOBILITY SHIFT ASSAY; GENOME ANALYSIS; GENOME-WIDE ASSOCIATION STUDY; HEREDITARY SENSORY AUTOSOMAL NEUROPATHY; HIGH THROUGHPUT SEQUENCING; HOMOZYGOSITY; HUMAN; HUMAN CELL; INDEL MUTATION; NEXT GENERATION SEQUENCING; NONHUMAN; POINT MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SENSORY NEUROPATHY; SINGLE NUCLEOTIDE POLYMORPHISM; SPANIEL; SPINAL GANGLION; TRANSCRIPTION REGULATION; ANIMAL; CHROMOSOMAL MAPPING; CONGENITAL ANALGESIA; DOG; GENE EXPRESSION REGULATION; GENETICS; NEUROPATHY; PAIN; PATHOPHYSIOLOGY;

ANIMALS; CHROMOSOME MAPPING; DOGS; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES; HUMANS; PAIN; PAIN INSENSITIVITY, CONGENITAL; POINT MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, LONG NONCODING;

EID: 85007602090     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006482     Document Type: Article

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