Enhancer RNAs: A class of long noncoding RNAs synthesized at enhancers

Cold Spring Harbor Perspectives in Biology

Volumn 7, Issue 1, 2015, Pages

  Kim, Tae Kyung ^a   Hemberg, Martin ^b   Gray, Jesse M ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LONG UNTRANSLATED RNA;

ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; MODELS, GENETIC; RNA, LONG NONCODING; TRANSCRIPTION, GENETIC;

EID: 84920516971     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a018622     Document Type: Article

References (5)

1. Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, et al. 2010. Widespread transcription at neuronal activity-regulated enhancers. Nature 465: 182–187.
2. Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shie-khattar R. 2013. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature 494: 497–501.
3. Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, et al. 2013. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature 498: 511–515.
4. Li W, Notani D, Ma Q, Tanasa B, Nunez E, Chen AY, Merkurjev D, Zhang J, Ohgi K, Song X, et al. 2013. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature 498: 516–520.
5. Melo CA, Drost J, Wijchers PJ, van de Werken H, de Wit E, Oude Vrielink JA, Elkon R, Melo SA, Leveille N, Kalluri R, et al. 2013. eRNAs are required for 53-dependent enhancer activity and gene transcription. Mol Cell 49: 524–535.