Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay

Hepatology

Volumn 65, Issue 2, 2017, Pages 604-615

  Zhang, Li ^a   Yang, Zhihong ^a,b   Trottier, Jocelyn ^c   Barbier, Olivier ^c   Wang, Li ^a,b,d,e  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITÉ LAVAL   (Canada)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYP8B1 PROTEIN; EPITHELIAL CELL ADHESION MOLECULE; GLYCOGEN SYNTHASE KINASE 3BETA; HETERODIMER; LONG UNTRANSLATED RNA; MATERNALLY EXPRESSED GENE 3 PROTEIN; POLYPYRIMIDINE TRACT BINDING PROTEIN; POLYPYRIMIDINE TRACT BINDING PROTEIN 1; PROTEIN; SMALL HETERODIMER PARTNER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MEG3 NON-CODING RNA, MOUSE; PTBP1 PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; BILE DUCT DISEASE; BINDING SITE; BIOINFORMATICS; CELL LYSATE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENTEROHEPATIC CIRCULATION; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HYDRODYNAMICS; HYPERTRANSAMINASEMIA; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LIVER FIBROSIS; LIVER INJURY; MASS SPECTROMETRY; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN RNA BINDING; QUANTITATIVE ANALYSIS; RNA DEGRADATION; RNA IMMUNOPRECIPITATION; RNA PROBE; RNA SEQUENCE; TANDEM MASS SPECTROMETRY; TRANSACTIVATION; UPREGULATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; CHOLESTASIS; CYTOLOGY; DISEASE MODEL; GENETICS; HEP-G2 CELL LINE; INJURIES; KNOCKOUT MOUSE; LIVER; LIVER CELL; METABOLISM; PATHOLOGY; PROMOTER REGION; RANDOMIZATION; RNA STABILITY; SENSITIVITY AND SPECIFICITY;

ANIMALS; BINDING SITES; CELLS, CULTURED; CHOLESTASIS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HEP G2 CELLS; HEPATOCYTES; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROMOTER REGIONS, GENETIC; RANDOM ALLOCATION; RNA STABILITY; RNA, LONG NONCODING; SENSITIVITY AND SPECIFICITY;

EID: 85007415651     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28882     Document Type: Article

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