Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

Metabolic Engineering

Volumn 43, Issue , 2017, Pages 198-207

  Jiang, Lei ^a   Boufersaoui, Adam ^a,d   Yang, Chendong ^a   Ko, Bookyung ^a   Rakheja, Dinesh ^b,c   Guevara, Gerardo ^a,e   Hu, Zeping ^a   DeBerardinis, Ralph J ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Children's Health   (United States)

^d UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^e UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

2HG; Cancer metabolism; Citrate transporter; IDH1; Lung cancer; SLC25A1

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLATION; CYTOLOGY; DISEASES; FATTY ACIDS; GLUCOSE; METABOLISM; MITOCHONDRIA; PHYSIOLOGY; PROTEINS;

CENTRAL CARBON METABOLISMS; CITRATE TRANSPORT PROTEIN; CITRATE TRANSPORTERS; IDH1; LUNG CANCER; MITOCHONDRIAL METABOLISM; MITOCHONDRIAL PRODUCTION; SLC25A1;

CELLS;

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; ASPARTATE AMINOTRANSFERASE; CARRIER PROTEIN; CITRIC ACID; FATTY ACID SYNTHASE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; ISOCITRATE DEHYDROGENASE 1; LACTATE DEHYDROGENASE; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE; ANION TRANSPORT PROTEIN; FATTY ACID; MITOCHONDRIAL PROTEIN; SLC25A1 PROTEIN, HUMAN; TUMOR PROTEIN;

AEROBIC METABOLISM; ARTICLE; CARBON METABOLISM; CARBOXYLATION; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOSOL; ENERGY YIELD; FATTY ACID SYNTHESIS; GLUCOSE INTAKE; HUMAN; HUMAN CELL; LIPOGENESIS; MEMBRANE TRANSPORT; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NCI-H460 CELL LINE; NON SMALL CELL LUNG CANCER; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; QUANTITATIVE ANALYSIS; BIOSYNTHESIS; DEFICIENCY; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; TUMOR CELL LINE;

ANION TRANSPORT PROTEINS; CELL LINE, TUMOR; FATTY ACIDS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEOPLASM PROTEINS; NEOPLASMS;

EID: 85007414686     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.11.004     Document Type: Article

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