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Volumn 108, Issue 6, 2016, Pages

Role of Increased n-acetylaspartate Levels in Cancer

(33)  Zand, Behrouz a   Previs, Rebecca A a   Zacharias, Niki M b   Rupaimoole, Rajesha a   Mitamura, Takashi a   Nagaraja, Archana Sidalaghatta a   Guindani, Michele b   Dalton, Heather J a   Yang, Lifeng b,i   Baddour, Joelle b,i   Achreja, Abhinav b,i   Hu, Wei a   Pecot, Chad V b   Ivan, Cristina c   Wu, Sherry Y a   McCullough, Christopher R b   Gharpure, Kshipra M a   Shoshan, Einav a   Pradeep, Sunila a   Mangala, Lingegowda S c   more..


Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID; ACYLTRANSFERASE; ASPARTIC ACID; N-ACETYLASPARTATE; NAT8 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84977070436     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djv426     Document Type: Article
Times cited : (55)

References (39)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 2011;144(5):646-674.
    • (2011) Cell. , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309-314.
    • (1956) Science. , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 3
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metabolism. 2008;7(1):11-20.
    • (2008) Cell Metabolism. , vol.7 , Issue.1 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 4
    • 60149091657 scopus 로고    scopus 로고
    • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    • Sreekumar A, Poisson LM, Rajendiran TM, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009;457(7231):910-914.
    • (2009) Nature. , vol.457 , Issue.7231 , pp. 910-914
    • Sreekumar, A.1    Poisson, L.M.2    Rajendiran, T.M.3
  • 5
    • 84875496294 scopus 로고    scopus 로고
    • (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
    • Losman JA, Looper RE, Koivunen P, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.
    • (2013) Science. , vol.339 , Issue.6127 , pp. 1621-1625
    • Losman, J.A.1    Looper, R.E.2    Koivunen, P.3
  • 6
    • 77956674635 scopus 로고    scopus 로고
    • Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    • Vander Heiden MG, Locasale JW, Swanson KD, et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010;329(5998):1492-1499.
    • (2010) Science. , vol.329 , Issue.5998 , pp. 1492-1499
    • Vander Heiden, M.G.1    Locasale, J.W.2    Swanson, K.D.3
  • 7
    • 80051923932 scopus 로고    scopus 로고
    • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    • Possemato R, Marks KM, Shaul YD, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011;476(7360):346-350.
    • (2011) Nature. , vol.476 , Issue.7360 , pp. 346-350
    • Possemato, R.1    Marks, K.M.2    Shaul, Y.D.3
  • 8
    • 84920972493 scopus 로고    scopus 로고
    • Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells
    • Salimian Rizi B, Caneba C, Nowicka A, et al. Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells. Cancer Res. 2015;75(2):456-471.
    • (2015) Cancer Res. , vol.75 , Issue.2 , pp. 456-471
    • Salimian Rizi, B.1    Caneba, C.2    Nowicka, A.3
  • 9
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang CV, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009;15(21):6479-6483.
    • (2009) Clin Cancer Res. , vol.15 , Issue.21 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 10
    • 84875894714 scopus 로고    scopus 로고
    • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    • Son J, Lyssiotis CA, Ying H, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013;496(7443):101-105.
    • (2013) Nature. , vol.496 , Issue.7443 , pp. 101-105
    • Son, J.1    Lyssiotis, C.A.2    Ying, H.3
  • 11
    • 68849083050 scopus 로고    scopus 로고
    • Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems
    • Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem. 2009;81(16):6656-6667.
    • (2009) Anal Chem. , vol.81 , Issue.16 , pp. 6656-6667
    • Evans, A.M.1    DeHaven, C.D.2    Barrett, T.3    Mitchell, M.4    Milgram, E.5
  • 12
    • 84864612118 scopus 로고    scopus 로고
    • Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients
    • Weiner J 3rd, Parida SK, Maertzdorf J, et al. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PloS One. 2012;7(7):e40221.
    • (2012) PloS One. , vol.7 , Issue.7 , pp. e40221
    • Weiner, J.1    Parida, S.K.2    Maertzdorf, J.3
  • 13
    • 44949233606 scopus 로고    scopus 로고
    • Analysis of the adult human plasma metabolome
    • Lawton KA, Berger A, Mitchell M, et al. Analysis of the adult human plasma metabolome. Pharmacogenomics. 2008;9(4):383-397.
    • (2008) Pharmacogenomics. , vol.9 , Issue.4 , pp. 383-397
    • Lawton, K.A.1    Berger, A.2    Mitchell, M.3
  • 14
    • 78649702566 scopus 로고    scopus 로고
    • Organization of GC/MS and LC/MS metabolomics data into chemical libraries
    • Dehaven CD, Evans AM, Dai H, Lawton KA. Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Cheminform. 2010;2(1):9.
    • (2010) J Cheminform. , vol.2 , Issue.1 , pp. 9
    • Dehaven, C.D.1    Evans, A.M.2    Dai, H.3    Lawton, K.A.4
  • 15
    • 58049213696 scopus 로고    scopus 로고
    • Dicer, drosha, and outcomes in patients with ovarian cancer
    • Merritt WM, Lin YG, Han LY, et al. Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer. New Engl J Med. 2008;359(25):2641-2650.
    • (2008) New Engl J Med. , vol.359 , Issue.25 , pp. 2641-2650
    • Merritt, W.M.1    Lin, Y.G.2    Han, L.Y.3
  • 16
    • 33746851955 scopus 로고    scopus 로고
    • Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
    • Thaker PH, Han LY, Kamat AA, et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 2006;12(8):939-944.
    • (2006) Nat Med. , vol.12 , Issue.8 , pp. 939-944
    • Thaker, P.H.1    Han, L.Y.2    Kamat, A.A.3
  • 17
    • 0024443170 scopus 로고
    • Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites
    • Li L, Price JE, Fan D, Zhang RD, Bucana CD, Fidler IJ. Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites. J Natl Cancer Inst. 1989;81(18):1406-1412.
    • (1989) J Natl Cancer Inst. , vol.81 , Issue.18 , pp. 1406-1412
    • Li, L.1    Price, J.E.2    Fan, D.3    Zhang, R.D.4    Bucana, C.D.5    Fidler, I.J.6
  • 18
    • 77955541508 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by EZH2
    • Lu C, Han HD, Mangala LS, et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell. 2010;18(2):185-197.
    • (2010) Cancer Cell. , vol.18 , Issue.2 , pp. 185-197
    • Lu, C.1    Han, H.D.2    Mangala, L.S.3
  • 19
    • 33750581780 scopus 로고    scopus 로고
    • Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer
    • Landen CN Jr, Lu C, Han LY, et al. Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer. J Natl Cancer Inst. 2006;98(21):1558-1570.
    • (2006) J Natl Cancer Inst. , vol.98 , Issue.21 , pp. 1558-1570
    • Landen, C.N.1    Lu, C.2    Han, L.Y.3
  • 20
    • 40949126550 scopus 로고    scopus 로고
    • Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth
    • Merritt WM, Lin YG, Spannuth WA, et al. Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth. J Natl Cancer Inst. 2008;100(5):359-372.
    • (2008) J Natl Cancer Inst. , vol.100 , Issue.5 , pp. 359-372
    • Merritt, W.M.1    Lin, Y.G.2    Spannuth, W.A.3
  • 21
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A. 2003;100(16):9440-9445.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , Issue.16 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 22
    • 52649085237 scopus 로고    scopus 로고
    • Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    • Tothill RW, Tinker AV, George J, et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res. 2008;14(16):5198-5208.
    • (2008) Clin Cancer Res. , vol.14 , Issue.16 , pp. 5198-5208
    • Tothill, R.W.1    Tinker, A.V.2    George, J.3
  • 23
    • 73949140415 scopus 로고    scopus 로고
    • Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
    • Bogunovic D, O'Neill DW, Belitskaya-Levy I, et al. Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. Proc Natl Acad Sci U S A. 2009;106(48):20429-20434.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.48 , pp. 20429-20434
    • Bogunovic, D.1    O'Neill, D.W.2    Belitskaya-Levy, I.3
  • 24
    • 77954234849 scopus 로고    scopus 로고
    • Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome
    • Jonsson G, Busch C, Knappskog S, et al. Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome. Clin Cancer Res. 2010;16(13):3356-3367.
    • (2010) Clin Cancer Res. , vol.16 , Issue.13 , pp. 3356-3367
    • Jonsson, G.1    Busch, C.2    Knappskog, S.3
  • 25
    • 70449647008 scopus 로고
    • Proportional hazards tests and diagnostics based on weighted residuals
    • Grambsch PM, Therneau TM. Proportional Hazards Tests and Diagnostics Based on Weighted Residuals. Biometrika. 1994;81(3):515-526.
    • (1994) Biometrika. , vol.81 , Issue.3 , pp. 515-526
    • Grambsch, P.M.1    Therneau, T.M.2
  • 26
    • 84903764168 scopus 로고    scopus 로고
    • Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells
    • Caneba CA, Yang L, Baddour J, et al. Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells. Cell Death Dis. 2014;5:e1302.
    • (2014) Cell Death Dis. , vol.5 , pp. e1302
    • Caneba, C.A.1    Yang, L.2    Baddour, J.3
  • 27
    • 84901624185 scopus 로고    scopus 로고
    • Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
    • Yang L, Moss T, Mangala LS, et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol. 2014;10:728.
    • (2014) Mol Syst Biol. , vol.10 , pp. 728
    • Yang, L.1    Moss, T.2    Mangala, L.S.3
  • 28
    • 84862630475 scopus 로고    scopus 로고
    • NetWalker: A contextual network analysis tool for functional genomics
    • Komurov K, Dursun S, Erdin S, Ram PT. NetWalker: A contextual network analysis tool for functional genomics. BMC Genomics. 2012;13:282.
    • (2012) BMC Genomics. , vol.13 , pp. 282
    • Komurov, K.1    Dursun, S.2    Erdin, S.3    Ram, P.T.4
  • 29
    • 0000356642 scopus 로고
    • Studies on the distribution of N-acetyl-L-aspartic acid in brain
    • Tallan HH. Studies on the distribution of N-acetyl-L-aspartic acid in brain. J Biol Chem. 1957;224(1):41-45.
    • (1957) J Biol Chem. , vol.224 , Issue.1 , pp. 41-45
    • Tallan, H.H.1
  • 30
    • 0000701624 scopus 로고
    • Studies on the free amino acids and related compounds in the tissues of the cat
    • Tallan HH, Moore S, Stein WH. Studies on the free amino acids and related compounds in the tissues of the cat. J Biol Chem. 1954;211(2):927-939.
    • (1954) J Biol Chem. , vol.211 , Issue.2 , pp. 927-939
    • Tallan, H.H.1    Moore, S.2    Stein, W.H.3
  • 31
    • 77952240030 scopus 로고    scopus 로고
    • Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: Implications for specialized acetyl coenzyme A metabolism in the CNS
    • Ariyannur PS, Moffett JR, Manickam P, et al. Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. Brain Res. 2010;1335:1-13.
    • (2010) Brain Res. , vol.1335 , pp. 1-13
    • Ariyannur, P.S.1    Moffett, J.R.2    Manickam, P.3
  • 32
    • 72449146905 scopus 로고    scopus 로고
    • Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia
    • Wiame E, Tyteca D, Pierrot N, et al. Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia. Biochem J. 2010;425(1):127-136.
    • (2010) Biochem J. , vol.425 , Issue.1 , pp. 127-136
    • Wiame, E.1    Tyteca, D.2    Pierrot, N.3
  • 34
    • 84864285263 scopus 로고    scopus 로고
    • Differences in metabolism of fiber tract alterations in gliomas: A combined fiber density mapping and magnetic resonance spectroscopic imaging study
    • Stadlbauer A, Hammen T, Buchfelder M, et al. Differences in metabolism of fiber tract alterations in gliomas: A combined fiber density mapping and magnetic resonance spectroscopic imaging study. Neurosurgery. 2012;71(2):454-463.
    • (2012) Neurosurgery. , vol.71 , Issue.2 , pp. 454-463
    • Stadlbauer, A.1    Hammen, T.2    Buchfelder, M.3
  • 35
    • 84877100892 scopus 로고    scopus 로고
    • Survival analysis in patients with newly diagnosed glioblastoma using pre-and postradiotherapy MR spectroscopic imaging
    • Li Y, Lupo JM, Parvataneni R, et al. Survival analysis in patients with newly diagnosed glioblastoma using pre-and postradiotherapy MR spectroscopic imaging. Neuro-oncology. 2013;15(5):607-617.
    • (2013) Neuro-oncology. , vol.15 , Issue.5 , pp. 607-617
    • Li, Y.1    Lupo, J.M.2    Parvataneni, R.3
  • 36
    • 84864581956 scopus 로고    scopus 로고
    • Metabolite detection of pancreatic carcinoma by in vivo proton MR spectroscopy at 3T: Initial results
    • Yao X, Zeng M, Wang H, Fei S, Rao S, Ji Y. Metabolite detection of pancreatic carcinoma by in vivo proton MR spectroscopy at 3T: initial results. Radiol Med. 2012;117(5):780-788.
    • (2012) Radiol Med. , vol.117 , Issue.5 , pp. 780-788
    • Yao, X.1    Zeng, M.2    Wang, H.3    Fei, S.4    Rao, S.5    Ji, Y.6
  • 37
    • 79956289372 scopus 로고    scopus 로고
    • Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer
    • Fong MY, McDunn J, Kakar SS. Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. PloS One. 2011;6(5):e19963.
    • (2011) PloS One. , vol.6 , Issue.5 , pp. e19963
    • Fong, M.Y.1    McDunn, J.2    Kakar, S.S.3
  • 38
    • 79959197094 scopus 로고    scopus 로고
    • Metabolomic characterization of ovarian epithelial carcinomas by HRMAS-NMR spectroscopy
    • Ben Sellem D, Elbayed K, Neuville A, et al. Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy. J Oncol. 2011;2011:174019.
    • (2011) J Oncol. , vol.2011 , pp. 174019
    • Ben Sellem, D.1    Elbayed, K.2    Neuville, A.3
  • 39
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research N. Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474(7353):609-615.
    • (2011) Nature. , vol.474 , Issue.7353 , pp. 609-615
    • Cancer Genome Atlas Research N1


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