Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 2, 2017, Pages 665-676

  Abdelazeem, Ahmed H ^a,b   El Saadi, Mohammed T ^a   Safi El Din, Asmaa G ^a   Omar, Hany A ^a,c   El Moghazy, Samir M ^d  

^a Beni Suef University   (Egypt)

^b TAIF UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF SHARJAH   (United Arab Emirates)

^d CAIRO UNIVERSITY   (Egypt)

Author keywords

Analgesic; Anti inflammatory; Diarylimidazole; Diarylthiazole; Mofezolac; Selective COX 1; Ulcerogenicity

Indexed keywords

(4,5 DIPHENYLTHIAZOL 2 YL)GLYCINE; 2 (4,5 DIPHENYL 1H IMIDAZOL 1 YL) 1 (4 METHYLPIPERAZIN 1 YL)ETHANONE; 2 (4,5 DIPHENYL 1H IMIDAZOL 1 YL) 1 (PIPERIDIN 1 YL)ETHANONE; 2 (4,5 DIPHENYL 1H IMIDAZOL 1 YL) 1 MORPHOLINOETHANONE; 2 (4,5 DIPHENYL 1H IMIDAZOL 1 YL)ACETIC ACID; 2 [(4,5 DIPHENYLTHIAZOL 2 YL)AMINO] 1 (4 METHYLPIPERAZIN 1 YL)ETHANONE; 2 [(4,5 DIPHENYLTHIAZOL 2 YL)AMINO] 1 (PIPERIDIN 1 YL)ETHANONE; 2 [(4,5 DIPHENYLTHIAZOL 2 YL)AMINO] 1 MORPHOLINOETHANONE; 2 [4,5 BIS(4 METHOXYPHENYL) 1H IMIDAZOL 1 YL] 1 (4 METHYLPIPERAZIN 1 YL)ETHANONE; 2 [4,5 BIS(4 METHOXYPHENYL) 1H IMIDAZOL 1 YL] 1 (PIPERIDIN 1 YL)ETHANONE; 2 [4,5 BIS(4 METHOXYPHENYL) 1H IMIDAZOL 1 YL] 1 MORPHOLINOETHANONE; 2 [4,5 BIS(4 METHOXYPHENYL) 1H IMIDAZOL 1 YL]ACETIC ACID; 2 [[4,5 BIS(4 METHOXYPHENYL)THIAZOL 2 YL]AMINO] 1 (4 METHYLPIPERAZIN 1 YL)ETHANONE; 2 [[4,5 BIS(4 METHOXYPHENYL)THIAZOL 2 YL]AMINO] 1 (PIPERIDIN 1 YL)ETHANONE; 2 [[4,5 BIS(4 METHOXYPHENYL)THIAZOL 2 YL]AMINO] 1 MORPHOLINOETHANONE; 4,5 BIS(4 METHOXYPHENYL) 1H IMIDAZOLE; 4,5 DIARYLTHIAZOLE DERIVATIVE; 4,5 DIPHENYL 1H IMIDAZOLE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; DIARYLIMIDAZOLE DERIVATIVE; DICLOFENAC; ETHYL 2 [(4,5 BIS(4 METHOXYPHENYL)THIAZOL 2 YL)AMINO]ACETATE; FR 122047; INDOMETACIN; MOFEZOLAC; UNCLASSIFIED DRUG; UNINDEXED DRUG; [4,5 BIS(4 METHOXYPHENYL)THIAZOL 2 YL]GLYCINE; ACETIC ACID; CARRAGEENAN; CYCLOOXYGENASE 1; IMIDAZOLE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; THIAZOLE DERIVATIVE;

ADULT; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CLINICAL EFFECTIVENESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERANCE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; NONHUMAN; RAT; ULCEROGENESIS; WRITHING TEST; ANIMAL; BOVINE; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; EDEMA; ENZYMOLOGY; HUMAN; METABOLISM; PAIN; STOMACH MUCOSA; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CATTLE; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; EDEMA; FEMALE; GASTRIC MUCOSA; HUMANS; IMIDAZOLES; MALE; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PAIN; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 85007251540     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.11.037     Document Type: Article

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