Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 13, 2015, Pages 3248-3259

  Abdelazeem, Ahmed H ^a   Khan, Shabana I ^b   White, Stephen W ^c   Sufka, Kenneth J ^b,c   McCurdy, Christopher R ^b,c  

^a Beni Suef University   (Egypt)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Anti inflammatory analgesic; Benzothiazolone; Benzoxazolone; Dimers; iNOS; NF B; Nociception; Piperazine

Indexed keywords

1,4 BIS[4 (BENZO[D]THIAZOL 2 YLTHIO)BUTYL]PIPERAZINE; 3 [5 [4 [6 (2 OXOBENZO[D]THIAZOL 3(2H) YL)HEXYL]PIPERAZIN 1 YL]PENTYL]BENZO[D]THIAZOL 2(3H) ONE; 3,3' [PIPERAZINE 1,4 DIYLBIS(HEXANE 6,1 DIYL)]BIS(BENZO[D]THIAAZOL 2(3H) ONE); ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KETOROLAC; N(G) METHYLARGININE; PARTHENOLIDE; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE; BENZOXAZOLONE; CARRAGEENAN; NONSTEROID ANTIINFLAMMATORY AGENT; NOS2 PROTEIN, HUMAN;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PAIN; PAW EDEMA; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; CHLOROCEBUS AETHIOPS; CYTOLOGY; DIMERIZATION; DRUG EFFECTS; EDEMA; EPITHELIUM CELL; HINDLIMB; KIDNEY; MACROPHAGE; METABOLISM; PATHOLOGY; PIG; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; VERO CELL LINE;

MAMMALIA;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOTHIAZOLES; BENZOXAZOLES; CARRAGEENAN; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; DIMERIZATION; DRUG DESIGN; EDEMA; EPITHELIAL CELLS; HINDLIMB; HUMANS; KIDNEY; MACROPHAGES; MICE; MOLECULAR DOCKING SIMULATION; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; VERO CELLS;

EID: 84937410888     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.057     Document Type: Article

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