메뉴 건너뛰기




Volumn 76, Issue 24, 2016, Pages 7106-7117

Surface expression of TGFβ docking receptor GARP promotes oncogenesis and immune tolerance in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN GARP; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN; UNCLASSIFIED DRUG; LRRC32 PROTEIN, HUMAN; MEMBRANE PROTEIN;

EID: 85006870995     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-16-1456     Document Type: Article
Times cited : (78)

References (49)
  • 2
    • 0027984836 scopus 로고
    • The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins
    • Ollendorff V, Noguchi T, deLapeyriere O, Birnbaum D. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ 1994;5:213-9.
    • (1994) Cell Growth Differ , vol.5 , pp. 213-219
    • Ollendorff, V.1    Noguchi, T.2    DeLapeyriere, O.3    Birnbaum, D.4
  • 4
    • 50549098084 scopus 로고    scopus 로고
    • Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
    • Wang R, Wan Q, Kozhaya L, Fujii H, Unutmaz D. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS One 2008;3:e2705.
    • (2008) PLoS One , vol.3
    • Wang, R.1    Wan, Q.2    Kozhaya, L.3    Fujii, H.4    Unutmaz, D.5
  • 5
    • 69449085219 scopus 로고    scopus 로고
    • GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells
    • Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A 2009;106:13445-50.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13445-13450
    • Tran, D.Q.1    Andersson, J.2    Wang, R.3    Ramsey, H.4    Unutmaz, D.5    Shevach, E.M.6
  • 7
    • 73249123203 scopus 로고    scopus 로고
    • Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg
    • Stockis J, Colau D, Coulie PG, Lucas S. Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. Eur J Immunol 2009;39:3315-22.
    • (2009) Eur J Immunol , vol.39 , pp. 3315-3322
    • Stockis, J.1    Colau, D.2    Coulie, P.G.3    Lucas, S.4
  • 8
    • 84878071516 scopus 로고    scopus 로고
    • Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation
    • Edwards JP, Fujii H, Zhou AX, Creemers J, Unutmaz D, Shevach EM. Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol 2013;190:5506-15.
    • (2013) J Immunol , vol.190 , pp. 5506-5515
    • Edwards, J.P.1    Fujii, H.2    Zhou, A.X.3    Creemers, J.4    Unutmaz, D.5    Shevach, E.M.6
  • 9
    • 84887210986 scopus 로고    scopus 로고
    • Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4(+) T cells
    • Hahn SA, Stahl HF, Becker C, Correll A, Schneider FJ, Tuettenberg A, et al. Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4(+) T cells. Blood 2013;122:1182-91.
    • (2013) Blood , vol.122 , pp. 1182-1191
    • Hahn, S.A.1    Stahl, H.F.2    Becker, C.3    Correll, A.4    Schneider, F.J.5    Tuettenberg, A.6
  • 10
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001;29:117-29.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 11
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 2008;134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 12
    • 0032547895 scopus 로고    scopus 로고
    • TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M, Heider KH, Beug H. TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 1998;8:1243-52.
    • (1998) Curr Biol , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 13
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, et al. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001;12:27-36.
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3    Aakre, M.4    Lundquist, C.A.5    Engel, M.E.6
  • 14
    • 0022471924 scopus 로고
    • Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
    • Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A 1986;83:4167-71.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 4167-4171
    • Roberts, A.B.1    Sporn, M.B.2    Assoian, R.K.3    Smith, J.M.4    Roche, N.S.5    Wakefield, L.M.6
  • 15
    • 0028221238 scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells
    • Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, et al. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 1994;269:6271-4.
    • (1994) J Biol Chem , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3    Orpana, A.4    Ferrara, N.5    Saksela, O.6
  • 17
    • 0022465625 scopus 로고
    • Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth
    • Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, et al. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 1986;163:1037-50.
    • (1986) J Exp Med , vol.163 , pp. 1037-1050
    • Kehrl, J.H.1    Wakefield, L.M.2    Roberts, A.B.3    Jakowlew, S.4    Alvarez-Mon, M.5    Derynck, R.6
  • 18
    • 70350244537 scopus 로고    scopus 로고
    • Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity
    • Kopp HG, Placke T, Salih HR. Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity. Cancer Res 2009;69:7775-83.
    • (2009) Cancer Res , vol.69 , pp. 7775-7783
    • Kopp, H.G.1    Placke, T.2    Salih, H.R.3
  • 19
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: A master of all T cell trades
    • Li MO, Flavell RA. TGF-beta: a master of all T cell trades. Cell 2008;134:392-404.
    • (2008) Cell , vol.134 , pp. 392-404
    • Li, M.O.1    Flavell, R.A.2
  • 20
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A 2003;100:8430-5.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5
  • 21
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008;133:66-77.
    • (2008) Cell , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6
  • 22
  • 23
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment: TGFbeta: The molecular Jekyll and Hyde of cancer
    • Bierie B, Moses HL. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 2006;6:506-20.
    • (2006) Nat Rev Cancer , vol.6 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 24
    • 84886805255 scopus 로고    scopus 로고
    • Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
    • Bos PD, Plitas G, Rudra D, Lee SY, Rudensky AY. Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J Exp Med 2013;210:2435-66.
    • (2013) J Exp Med , vol.210 , pp. 2435-2466
    • Bos, P.D.1    Plitas, G.2    Rudra, D.3    Lee, S.Y.4    Rudensky, A.Y.5
  • 25
    • 84856945806 scopus 로고    scopus 로고
    • TGF-β: The sword, the wand, and the shield of FOXP3(+) regulatory T cells
    • Tran DQ. TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells. J Mol Cell Biol 2012;4:29-37.
    • (2012) J Mol Cell Biol , vol.4 , pp. 29-37
    • Tran, D.Q.1
  • 26
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 2000;14:163-76.
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 27
    • 0024382711 scopus 로고
    • Inhibition of endothelial cell movement by pericytes and smooth muscle cells: Activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture
    • Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. J Cell Biol 1989;109:309-15.
    • (1989) J Cell Biol , vol.109 , pp. 309-315
    • Sato, Y.1    Rifkin, D.B.2
  • 28
    • 0025215307 scopus 로고
    • Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin
    • Lyons RM, Gentry LE, Purchio AF, Moses HL. Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J Cell Biol 1990;110:1361-7.
    • (1990) J Cell Biol , vol.110 , pp. 1361-1367
    • Lyons, R.M.1    Gentry, L.E.2    Purchio, A.F.3    Moses, H.L.4
  • 30
    • 84884790901 scopus 로고    scopus 로고
    • GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells
    • Gauthy E, Cuende J, Stockis J, Huygens C, Lethe B, Collet JF, et al. GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells. PLoS One 2013;8:e76186.
    • (2013) PLoS One , vol.8
    • Gauthy, E.1    Cuende, J.2    Stockis, J.3    Huygens, C.4    Lethe, B.5    Collet, J.F.6
  • 31
    • 0034795208 scopus 로고    scopus 로고
    • Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability
    • Randow F, Seed B. Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat Cell Biol 2001;3:891-6.
    • (2001) Nat Cell Biol , vol.3 , pp. 891-896
    • Randow, F.1    Seed, B.2
  • 32
    • 79951472098 scopus 로고    scopus 로고
    • Identification of an mRNP complex regulating tumorigenesis at the translational elongation step
    • Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MC, et al. Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell 2011;41:419-31.
    • (2011) Mol Cell , vol.41 , pp. 419-431
    • Hussey, G.S.1    Chaudhury, A.2    Dawson, A.E.3    Lindner, D.J.4    Knudsen, C.R.5    Wilce, M.C.6
  • 33
    • 84875433210 scopus 로고    scopus 로고
    • Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker
    • Rachidi SM, Qin T, Sun S, Zheng WJ, Li Z. Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker. PLoS One 2013;8:e57911.
    • (2013) PLoS One , vol.8
    • Rachidi, S.M.1    Qin, T.2    Sun, S.3    Zheng, W.J.4    Li, Z.5
  • 34
    • 84863115806 scopus 로고    scopus 로고
    • The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain
    • Wu S, Hong F, Gewirth D, Guo B, Liu B, Li Z. The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain. J Biol Chem 2012;287:6735-42.
    • (2012) J Biol Chem , vol.287 , pp. 6735-6742
    • Wu, S.1    Hong, F.2    Gewirth, D.3    Guo, B.4    Liu, B.5    Li, Z.6
  • 35
    • 84880065073 scopus 로고    scopus 로고
    • a7 helix region of alphaI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: A potential therapeutic target for cancer metastasis
    • Hong F, Liu B, Chiosis G, Gewirth DT, Li Z. a7 helix region of alphaI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis. J Biol Chem 2013;288:18243-8.
    • (2013) J Biol Chem , vol.288 , pp. 18243-18248
    • Hong, F.1    Liu, B.2    Chiosis, G.3    Gewirth, D.T.4    Li, Z.5
  • 37
    • 8444244786 scopus 로고    scopus 로고
    • X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization
    • Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 2004;10:7252-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 7252-7259
    • Camp, R.L.1    Dolled-Filhart, M.2    Rimm, D.L.3
  • 38
    • 84932080470 scopus 로고    scopus 로고
    • Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells
    • Howley BV, Hussey GS, Link LA, Howe PH. Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells. Oncogene 2016;35:1725-35.
    • (2016) Oncogene , vol.35 , pp. 1725-1735
    • Howley, B.V.1    Hussey, G.S.2    Link, L.A.3    Howe, P.H.4
  • 39
    • 0642306119 scopus 로고    scopus 로고
    • Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line
    • Xie L, Law BK, Aakre ME, Edgerton M, Shyr Y, Bhowmick NA, et al. Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res 2003;5:R187-98.
    • (2003) Breast Cancer Res , vol.5 , pp. R187-R198
    • Xie, L.1    Law, B.K.2    Aakre, M.E.3    Edgerton, M.4    Shyr, Y.5    Bhowmick, N.A.6
  • 40
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009;19:156-72.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 41
    • 43649096714 scopus 로고    scopus 로고
    • Mouse 4T1 breast tumor model
    • Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Hoboken, New Jersey: Wiley
    • Pulaski BA, Ostrand-Rosenberg S. Mouse 4T1 breast tumor model. In: Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. Hoboken, New Jersey: Wiley; 2001.
    • (2001) Current Protocols in Immunology
    • Pulaski, B.A.1    Ostrand-Rosenberg, S.2
  • 42
    • 0037097503 scopus 로고    scopus 로고
    • Cutting edge: Depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease
    • McHugh RS, Shevach EM. Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol 2002;168:5979-83.
    • (2002) J Immunol , vol.168 , pp. 5979-5983
    • McHugh, R.S.1    Shevach, E.M.2
  • 43
    • 33847401606 scopus 로고    scopus 로고
    • TLR4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells
    • Dai J, Liu B, Ngoi SM, Sun S, Vella AT, Li Z. TLR4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells. J Immunol 2007;178:3219-25.
    • (2007) J Immunol , vol.178 , pp. 3219-3225
    • Dai, J.1    Liu, B.2    Ngoi, S.M.3    Sun, S.4    Vella, A.T.5    Li, Z.6
  • 44
    • 84897380464 scopus 로고    scopus 로고
    • Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer
    • Chen X, Yang Y, Zhou Q, Weiss JM, Howard OZ, McPherson JM, et al. Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer. PLoS One 2014;9:e85398.
    • (2014) PLoS One , vol.9
    • Chen, X.1    Yang, Y.2    Zhou, Q.3    Weiss, J.M.4    Howard, O.Z.5    McPherson, J.M.6
  • 45
    • 40349116208 scopus 로고    scopus 로고
    • Colorectal cancer cells express functional cell surface-bound TGFβ
    • Baker K, Raut P, Jass JR. Colorectal cancer cells express functional cell surface-bound TGFβ. Int J Cancer 2008;122:1695-700.
    • (2008) Int J Cancer , vol.122 , pp. 1695-1700
    • Baker, K.1    Raut, P.2    Jass, J.R.3
  • 46
    • 77952337131 scopus 로고    scopus 로고
    • Presence of membrane-bound TGF-beta1 and its regulation by IL-2-activated immune cell-derived IFN-gamma in head and neck squamous cell carcinoma cell lines
    • Ahn YO, Lee JC, Sung MW, Heo DS. Presence of membrane-bound TGF-beta1 and its regulation by IL-2-activated immune cell-derived IFN-gamma in head and neck squamous cell carcinoma cell lines. J Immunol 2009;182:6114-20.
    • (2009) J Immunol , vol.182 , pp. 6114-6120
    • Ahn, Y.O.1    Lee, J.C.2    Sung, M.W.3    Heo, D.S.4
  • 48
    • 33746599842 scopus 로고    scopus 로고
    • Regulatory T cells in cancer
    • Beyer M, Schultze JL. Regulatory T cells in cancer. Blood 2006;108:804-11.
    • (2006) Blood , vol.108 , pp. 804-811
    • Beyer, M.1    Schultze, J.L.2
  • 49
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFβ signalling pathway in disease
    • Akhurst RJ, Hata A. Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov 2012;11:790-811.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.