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Volumn 35, Issue 13, 2016, Pages 1725-1735

Translational regulation of inhibin βa by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HNRNP E1 PROTEIN; HOMODIMER; INHIBIN BETA A; RNA BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; INHIBIN; INHIBIN BETA A SUBUNIT; PCBP1 PROTEIN, HUMAN;

EID: 84932080470     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.238     Document Type: Article
Times cited : (30)

References (32)
  • 1
    • 27644473229 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition
    • Radisky DC. Epithelial-mesenchymal transition. J Cell Sci 2005; 118: 4325-4326.
    • (2005) J Cell Sci , vol.118 , pp. 4325-4326
    • Radisky, D.C.1
  • 2
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 3
    • 0034644472 scopus 로고    scopus 로고
    • TGF signaling in growth control, cancer, and heritable disorders
    • Massagué J, Blain SW, Lo RS. TGF signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massagué, J.1    Blain, S.W.2    Lo, R.S.3
  • 4
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 2011; 145: 926-940.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5    Kah, K.J.6
  • 5
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 6
    • 77649261101 scopus 로고    scopus 로고
    • TGF-[beta]-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
    • Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH. TGF-[beta]-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol 2010; 12: 286-293.
    • (2010) Nat Cell Biol , vol.12 , pp. 286-293
    • Chaudhury, A.1    Hussey, G.S.2    Ray, P.S.3    Jin, G.4    Fox, P.L.5    Howe, P.H.6
  • 7
    • 79951472098 scopus 로고    scopus 로고
    • Identification of an mRNP complex regulating tumorigenesis at the translational elongation step
    • Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MC et al. Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell 2011; 41: 419-431.
    • (2011) Mol Cell , vol.41 , pp. 419-431
    • Hussey, G.S.1    Chaudhury, A.2    Dawson, A.E.3    Lindner, D.J.4    Knudsen, C.R.5    Wilce, M.C.6
  • 9
    • 0028872681 scopus 로고
    • Activin promotes ovarian follicle development in vitro
    • Li R, Phillips DM, Mather JP. Activin promotes ovarian follicle development in vitro. Endocrinology 1995; 136: 849-856.
    • (1995) Endocrinology , vol.136 , pp. 849-856
    • Li, R.1    Phillips, D.M.2    Mather, J.P.3
  • 12
    • 44449152487 scopus 로고    scopus 로고
    • The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF
    • Pearson S, Sroczynska P, Lacaud G, Kouskoff V. The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF. Development 2008; 135: 1525-1535.
    • (2008) Development , vol.135 , pp. 1525-1535
    • Pearson, S.1    Sroczynska, P.2    Lacaud, G.3    Kouskoff, V.4
  • 13
    • 36448936383 scopus 로고    scopus 로고
    • TGF[beta]-SMAD signal transduction: Molecular specificity and functional flexibility
    • Schmierer B, Hill CS. TGF[beta]-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007; 8: 970-982.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 15
    • 24744446473 scopus 로고    scopus 로고
    • Activin A mediates growth inhibition and cell cycle arrest through smads in human breast cancer cells
    • Burdette JE, Jeruss JS, Kurley SJ, Lee EJ, Woodruff TK. Activin A mediates growth inhibition and cell cycle arrest through smads in human breast cancer cells. Cancer Res 2005; 65: 7968-7975.
    • (2005) Cancer Res , vol.65 , pp. 7968-7975
    • Burdette, J.E.1    Jeruss, J.S.2    Kurley, S.J.3    Lee, E.J.4    Woodruff, T.K.5
  • 16
    • 80755141299 scopus 로고    scopus 로고
    • Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy
    • Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I et al. Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell Stem Cell 2011; 9: 433-446.
    • (2011) Cell Stem Cell , vol.9 , pp. 433-446
    • Lonardo, E.1    Hermann, P.C.2    Mueller, M.T.3    Huber, S.4    Balic, A.5    Miranda-Lorenzo, I.6
  • 19
    • 84864036162 scopus 로고    scopus 로고
    • Upregulated INHBA expression is associated with poor survival in gastric cancer
    • Wang Q, Wen YG, Li DP, Xia J, Zhou CZ, Yan DW et al. Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol 2012; 29: 77-83.
    • (2012) Med Oncol , vol.29 , pp. 77-83
    • Wang, Q.1    Wen, Y.G.2    Li, D.P.3    Xia, J.4    Zhou, C.Z.5    Yan, D.W.6
  • 21
    • 70349086989 scopus 로고    scopus 로고
    • Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer
    • Kang HY, Huang HY, Hsieh CY, Li CF, Shyr CR, Tsai MY et al. Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer. J Bone Miner Res 2009; 24: 1180-1193.
    • (2009) J Bone Miner Res , vol.24 , pp. 1180-1193
    • Kang, H.Y.1    Huang, H.Y.2    Hsieh, C.Y.3    Li, C.F.4    Shyr, C.R.5    Tsai, M.Y.6
  • 22
    • 78049348480 scopus 로고    scopus 로고
    • Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA THBS2 and COL11A1
    • Kim H, Watkinson J, Varadan V, Anastassiou D. Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1. BMC Med Genomics 2010; 3: 51.
    • (2010) BMC Med Genomics , vol.3 , pp. 51
    • Kim, H.1    Watkinson, J.2    Varadan, V.3    Anastassiou, D.4
  • 23
    • 34347232006 scopus 로고    scopus 로고
    • N-linked oligosaccharides direct the differential assembly and secretion of inhibin-and A-subunit dimers
    • Antenos M, Stemler M, Boime I, Woodruff TK. N-linked oligosaccharides direct the differential assembly and secretion of inhibin-and A-subunit dimers. Mol Endocrinol 2007; 21: 1670-1684.
    • (2007) Mol Endocrinol , vol.21 , pp. 1670-1684
    • Antenos, M.1    Stemler, M.2    Boime, I.3    Woodruff, T.K.4
  • 24
    • 0033377867 scopus 로고    scopus 로고
    • TGF-(beta) type i receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 1999; 112: 4557-4568.
    • (1999) J Cell Sci , vol.112 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Ch, H.4    Ten Dijke, P.5
  • 25
    • 84867984708 scopus 로고    scopus 로고
    • Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
    • Gunasinghe NP, Wells A, Thompson EW, Hugo HJ. Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. Cancer Metastasis Rev 2012; 31: 469-478.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 469-478
    • Gunasinghe, N.P.1    Wells, A.2    Thompson, E.W.3    Hugo, H.J.4
  • 26
    • 80053159808 scopus 로고    scopus 로고
    • IL-1 stimulates activin A mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-B pathway, and prostaglandin E2
    • Arai KY, Ono M, Kudo C, Fujioka A, Okamura R, Nomura Y et al. IL-1 stimulates activin A mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-B pathway, and prostaglandin E2. Endocrinology 2011; 152: 3779-3790.
    • (2011) Endocrinology , vol.152 , pp. 3779-3790
    • Arai, K.Y.1    Ono, M.2    Kudo, C.3    Fujioka, A.4    Okamura, R.5    Nomura, Y.6
  • 27
    • 84920982352 scopus 로고    scopus 로고
    • Activin upregulation by NF-B is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer
    • Wamsley JJ, Kumar M, Allison DF, Clift SH, Holzknecht CM, Szymura SJ et al. Activin upregulation by NF-B is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer. Cancer Res 2014; 75: 426-435.
    • (2014) Cancer Res , vol.75 , pp. 426-435
    • Wamsley, J.J.1    Kumar, M.2    Allison, D.F.3    Clift, S.H.4    Holzknecht, C.M.5    Szymura, S.J.6
  • 28
    • 16344378397 scopus 로고    scopus 로고
    • TGF-and the smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition
    • Valcourt U, Kowanetz M, Niimi H, Heldin C-H, Moustakas A. TGF-and the smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition. Mol Biol Cell 2005; 16: 1987-2002.
    • (2005) Mol Biol Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.-H.4    Moustakas, A.5
  • 29
    • 79959814756 scopus 로고    scopus 로고
    • Graded nodal/activin signaling titrates conversion of quantitative phospho-smad2 levels into qualitative embryonic stem cell fate decisions
    • Lee KL, Lim SK, Orlov YL, Yit LY, Yang H, Ang LT et al. Graded nodal/activin signaling titrates conversion of quantitative phospho-smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet 2011; 7: e1002130.
    • (2011) PLoS Genet , vol.7 , pp. e1002130
    • Lee, K.L.1    Lim, S.K.2    Orlov, Y.L.3    Yit, L.Y.4    Yang, H.5    Ang, L.T.6
  • 30
    • 10344249892 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells
    • Kim ES, Kim MS, Moon A. Transforming growth factor (TGF)-in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells. Cytokine 2005; 29: 84-91.
    • (2005) Cytokine , vol.29 , pp. 84-91
    • Kim, E.S.1    Kim, M.S.2    Moon, A.3
  • 31
    • 65549129119 scopus 로고    scopus 로고
    • Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma
    • Seder CW, Hartojo W, Lin L, Silvers AL, Wang Z, Thomas DG et al. Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. Neoplasia 2009; 11: 388-396.
    • (2009) Neoplasia , vol.11 , pp. 388-396
    • Seder, C.W.1    Hartojo, W.2    Lin, L.3    Silvers, A.L.4    Wang, Z.5    Thomas, D.G.6
  • 32
    • 77956304734 scopus 로고    scopus 로고
    • Enrichment for breast cancer cells with stem/progenitor properties by differential adhesion
    • Walia V, Elble RC. Enrichment for breast cancer cells with stem/progenitor properties by differential adhesion. Stem Cells Dev 2010; 19: 1175-1182.
    • (2010) Stem Cells Dev , vol.19 , pp. 1175-1182
    • Walia, V.1    Elble, R.C.2


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