Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis

Biochemical and Biophysical Research Communications

Volumn 482, Issue 2, 2017, Pages 195-201

  Sakamoto, Kotaro ^a   Sogabe, Satoshi ^a   Kamada, Yusuke ^a   Matsumoto, Shin ichi ^a   Kadotani, Akito ^a   Sakamoto, Jun ichi ^a   Tani, Akiyoshi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Crystal structure; GPX4; Inhibitor; Peptide; Phage display

Indexed keywords

OXIDOREDUCTASE INHIBITOR; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; ENZYME INHIBITOR; GLUTATHIONE PEROXIDASE; PEPTIDE; PEPTIDE LIBRARY; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROTEIN BINDING;

ARTICLE; CRYSTAL STRUCTURE; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENTEROBACTERIA PHAGE T7; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PEPTIDE LIBRARY; PHAGE DISPLAY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; ENZYME ACTIVATION; GENETICS; PRECLINICAL STUDY; PROCEDURES; PROTEIN CONFORMATION;

BACTERIOPHAGE T7; BINDING SITES; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUTATHIONE PEROXIDASE; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 85006619154     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.11.035     Document Type: Article

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