Human IgA-binding peptides selected from random peptide libraries: Affinity maturation and application in IGA purification

Journal of Biological Chemistry

Volumn 287, Issue 51, 2012, Pages 43126-43136

  Hatanaka, Takaaki ^a   Ohzono, Shinji ^b   Park, Mirae ^c   Sakamoto, Kotaro ^a,e   Tsukamoto, Shogo ^a   Sugita, Ryohei ^a   Ishitobi, Hiroyuki ^b   Mori, Toshiyuki ^d,e   Ito, Osamu ^b   Sorajo, Koichi ^b   Sugimura, Kazuhisa ^a   Ham, Sihyun ^c   Ito, Yuji ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b OTSUKA CHEMICAL CO LTD   (Japan)

^c Sookmyung Women's University   (South Korea)

^d NATIONAL CANCER INSTITUTE   (United States)

^e TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY MATURATION; BINDING AFFINITIES; BINDING SPECIFICITIES; BIOPANNING; EXPLICIT WATER; HELICITIES; HIGH SPECIFICITY; HUMAN PLASMAS; HYDROPHOBIC CLUSTERS; HYDROPHOBIC RESIDUES; MOLECULAR DYNAMICS SIMULATIONS; N-TERMINALS; NON-SPECIFIC BINDING; PEPTIDE LIBRARY; PHAGE DISPLAY; RANDOMIZED PHAGE DISPLAY LIBRARY; STRUCTURAL FEATURE; SUCCESSFUL ISOLATION; SYNTHETIC PEPTIDE; TARGET MOLECULE; TIGHT BINDING;

BINDING ENERGY; CLONING; DISPLAY DEVICES; HYDROPHOBICITY; LIBRARIES; MOLECULAR DYNAMICS;

PEPTIDES;

IMMUNOGLOBULIN A; PEPTIDE OPT 1; PEPTIDE OPT 3; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIOPHAGE T7; BINDING AFFINITY; BIOPANNING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MOLECULAR CLONING; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PEPTIDE LIBRARY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN ISOLATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; CHROMATOGRAPHY, AFFINITY; CONSERVED SEQUENCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN A; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; RECEPTORS, FC; REPRODUCIBILITY OF RESULTS; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

EID: 84871106210     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.389742     Document Type: Article

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