Mechanism of TH2/TH17-predominant and neutrophilic TH2/TH17-low subtypes of asthma

Journal of Allergy and Clinical Immunology

Volumn 139, Issue 5, 2017, Pages 1548-1558.e4

  Liu, Weimin ^a   Liu, Sucai ^a   Verma, Mukesh ^a   Zafar, Iram ^a   Good, James T ^a,b   Rollins, Donald ^a,b   Groshong, Stephen ^a,b   Gorska, Magdalena M ^a,b   Martin, Richard J ^a,b   Alam, Rafeul ^a,b  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma endotype; C3a; IL 1; infection; neutrophilic asthma; TH2 TH17 predominant asthma

Indexed keywords

ANAKINRA; COMPLEMENT COMPONENT C3A; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; CYTOKINE; LIPOPOLYSACCHARIDE; SERUM AMYLOID A;

ADULT; AIRWAY EPITHELIUM CELL; ARTICLE; ASTHMA; BODY MASS; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LEUKOCYTE; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUTROPHIL; NEUTROPHIL COUNT; PRIORITY JOURNAL; TH17 CELL; TH2 CELL; BRONCHOALVEOLAR LAVAGE FLUID; CELL CULTURE; CELL LINE; CYTOLOGY; EPITHELIUM CELL; IMMUNOLOGY; LEUKOCYTE COUNT;

ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE; CELLS, CULTURED; COMPLEMENT C3A; CYTOKINES; EPITHELIAL CELLS; HUMANS; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SERUM AMYLOID A PROTEIN; TH17 CELLS; TH2 CELLS;

EID: 85006256524     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.08.032     Document Type: Article

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