Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

Respiratory Research

Volumn 14, Issue 1, 2013, Pages

  Desai, Dhananjay ^a,b   Gupta, Sumit ^a,b   Siddiqui, Salman ^a,b   Singapuri, Amisha ^a,b   Monteiro, William ^a,b   Entwisle, James ^a,b,c   Visvanathan, Sudha ^d   Parmar, Harsukh ^d   Kajekar, Radhika ^d   Brightling, Christopher E ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

^c Wellington Hospital   (New Zealand)

^d Hoffmann La Roche ^*  (United States)

Author keywords

Asthma; RB1 bronchus; Remodelling

Indexed keywords

BLOOD CLOTTING FACTOR 7; BRONCHODILATING AGENT; CORTICOSTEROID; EOTAXIN; FERRITIN; FIBRINOGEN; GELATINASE B; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PREDNISOLONE; AUTACOID; BIOLOGICAL MARKER; CCL11 PROTEIN, HUMAN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; MMP9 PROTEIN, HUMAN;

ADULT; ARTICLE; ASTHMA; CELL COUNT; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; GEOMETRY; HUMAN; IMAGING; INFLAMMATION; LUNG LOBE; MAJOR CLINICAL STUDY; MALE; MEDIATOR RELEASE; NEUTROPHIL COUNT; OBSERVATIONAL STUDY; PHENOTYPE; QUANTITATIVE ANALYSIS; SPUTUM CULTURE; SPUTUM EXAMINATION; AIRWAY REMODELING; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CROSS-SECTIONAL STUDY; IMMUNOLOGY; LEUKOCYTE COUNT; LUNG; MIDDLE AGED; NEUTROPHIL; PREDICTIVE VALUE; RADIOGRAPHY; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; SPUTUM; UNITED KINGDOM;

ADULT; AIRWAY REMODELING; ASTHMA; BIOLOGICAL MARKERS; CHEMOKINE CCL11; CROSS-SECTIONAL STUDIES; ENGLAND; FEMALE; FIBRINOGEN; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; LEUKOCYTE COUNT; LUNG; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; NEUTROPHILS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SPUTUM; TOMOGRAPHY, X-RAY COMPUTED;

MLCS; MLOWN;

EID: 84873518011     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-17     Document Type: Article

References (44)

1. Bousquet J, Mantzouranis E, Cruz AA, Aït-Khaled N, Baena-Cagnani CE, Bleecker ER, Brightling CE, Burney P, Bush A, Busse WW, Casale TB, Chan-Yeung M, Chen R, Chowdhury B, Chung KF, Dahl R, Drazen JM, Fabbri LM, Holgate ST, Kauffmann F, Haahtela T, Khaltaev N, Kiley JP, Masjedi MR, Mohammad Y, O'Byrne P, Partridge MR, Rabe KF, Togias A, van Weel C, Wenzel S, Zhong N, Zuberbier T. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010, 126(5):926-38. 10.1016/j.jaci.2010.07.019, 20926125.
2. Bel EH, Sousa A, Fleming L. Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI). Thorax 2011, 66(10):910-7. 10.1136/thx.2010.153643, 21106547.
3. Brightling CE, Gupta S, Gonem S, Siddiqui S. Lung damage and airway remodelling in severe asthma. Clin Exp Allergy 2012, 42(5):638-49. 10.1111/j.1365-2222.2011.03917.x, 22192725.
4. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care. 2009, 180(5):388-95.
5. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008, 178(3):218-24. 10.1164/rccm.200711-1754OC, 18480428.
6. Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, Marshall RP, Bradding P, Green RH, Wardlaw AJ, Pavord ID. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009, 360(10):973-84. 10.1056/NEJMoa0808991, 19264686.
7. Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011, 365(12):1088-98. 10.1056/NEJMoa1106469, 21812663.
8. Piper E, Brightling CE, Niven R, Oh C, Faggioni R, Poon K, She D, Kell C, May RD, Geba G, Molfino NA. A phase 2 placebo- controlled study of tralokinumab in moderate-to -severe asthma. Eur Respir J 2012, in press.
9. Gupta S, Siddiqui S, Haldar P, Raj JV, Entwisle JJ, Wardlaw AJ, Bradding P, Pavord ID, Green RH, Brightling CE. Qualitative analysis of high-resolution CT scans in severe asthma. Chest 2009, 136(6):1521-8. 10.1378/chest.09-0174, 2816977, 19542254.
10. Gupta S, Siddiqui S, Haldar P, Entwisle JJ, Mawby D, Wardlaw AJ, Bradding P, Pavord ID, Green RH, Brightling CE. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax 2010, 65(9):775-81. 10.1136/thx.2010.136374, 2975950, 20805170.
11. Castro M, Fain SB, Hoffman EA, Gierada DS, Erzurum SC, Wenzel S. National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Lung imaging in asthmatic patients: the picture is clearer. J Allergy Clin Immunol 2011, 128(3):467-78. 10.1016/j.jaci.2011.04.051, 3187916, 21636118.
12. Stǎnescu D, Sanna A, Veriter C, Kostianev S, Calcagni PG, Fabbri LM, Maestrelli P. Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax 1996, 51(3):267-71. 10.1136/thx.51.3.267, 1090637, 8779129.
13. Shaw DE, Berry MA, Hargadon B, McKenna S, Shelley MJ, Green RH, Brightling CE, Wardlaw AJ, Pavord ID. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. Chest 2007, 132(6):1871-5. 10.1378/chest.07-1047, 17925424.
14. Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol 2011, 127(1):153-60. 10.1016/j.jaci.2010.10.024, 21211650.
15. Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER. National Heart, Lung, and Blood Institute Severe Asthma Research Program. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 2010, 125(5):1028-1036. 10.1016/j.jaci.2010.02.008, 2878277, 20398920.
16. Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE. Acute exacerbations of COPD: Identification of biological clusters and their biomarkers. Am J Respir Crit Care Med 2011, 184(6):662-71. 10.1164/rccm.201104-0597OC, 21680942.
17. Bafadhel M, McCormick M, Saha S, McKenna S, Shelley M, Hargadon B, Mistry V, Reid C, Parker D, Dodson P, Jenkins M, Lloyd A, Rugman P, Newbold P, Brightling CE. Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease. Respiration 2012, 83(1):36-44. 10.1159/000330667, 3417284, 21912093.
18. Pavord ID, Pizzichini MM, Pizzichini E, Hargreave FE. The use of induced sputum to investigate airway inflammation. Thorax 1997, 52(6):498-501. 10.1136/thx.52.6.498, 1758588, 9227713.
19. Juniper EF, Svensson K, Mörk AC, Ståhl E. Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. Respir Med 2005, 99:553-8. 10.1016/j.rmed.2004.10.008, 15823451.
20. Reddel HK, Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, Chanez P, Enright PL, Gibson PG, de Jongste JC, Kerstjens HA, Lazarus SC, Levy ML, O'Byrne PM, Partridge MR, Pavord ID, Sears MR, Sterk PJ, Stoloff SW, Sullivan SD, Szefler SJ, Thomas MD, Wenzel SE. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009, 180(1):59-99. 10.1164/rccm.200801-060ST, 19535666.
21. Proceedings of the ATS Workshop on Refractory Asthma Current Understanding, Recommendations, and Unanswered Questions. Am J Respir Crit Care Med 2000, 162(6):2341-2351. Proceedings of the ATS Workshop on Refractory Asthma.
22. Nakano Y, Wong JC, De Jong PA, Buzatu L, Nagao T, Coxson HO. The prediction of small airway dimensions using computed tomography. Am J Respir Crit Care Med 2005, 171:142-146.
23. Siddiqui S, Gupta S, Cruse G, Haldar P, Entwisle J, Mcdonald S, Whithers PJ, Hainsworth SV, Coxson HO, Brightling C. Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis. Allergy 2009, 64(6):951-8. 10.1111/j.1398-9995.2009.01951.x, 19210350.
24. Saba OI, Hoffman EA, Reinhardt JM. Maximizing quantitative accuracy of lung airway lumen and wall measures obtained from X-ray CT imaging. J Appl Physiol 2003, 95(3):1063-75.
25. Kelly M, Leigh R, Hargreave FE. Validation of assays for inflammatory mediators in sputum. Eur Respir J 2000, 166:1208-1209.
26. Pizzichini MM, Popov TA, Efthimiadis A, Hussack P, Evans S, Pizzichini E, Dolovich J, Hargreave FE. Spontaneous and induced sputum to measure indices of airway inflammation in asthma. Am J Respir Crit Care Med 1996, 154:866-9.
27. Pazdrak K, Young TW, Stafford S, Olszewska-Pazdrak B, Straub C, Starosta V, Brasier A, Kurosky A. Cross-talk between ICAM-1 and granulocyte-macrophage colony-stimulating factor receptor signaling modulates eosinophil survival and activation. J Immunol 2008, 180(6):4182-90.
28. Matsumoto H, Niimi A, Takemura M, Ueda T, Minakuchi M, Tabuena R, Chin K, Mio T, Ito Y, Muro S, Hirai T, Morita S, Fukuhara S, Mishima M. Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma. Thorax 2005, 60(4):277-81. 10.1136/thx.2004.028936, 1747359, 15790981.
29. Lappalainen U, Whitsett JA, Wert SE, Tichelaar JW, Bry K. Interleukin-1β Causes Pulmonary Inflammation, Emphysema, and Airway Remodeling in the Adult Murine Lung. Am J Respir Cell Mol Biol 2005, 32(4):311-8. 10.1165/rcmb.2004-0309OC, 15668323.
30. Maclay JD, McAllister DA, Rabinovich R, Haq I, Maxwell S, Hartland S, Connell M, Murchison JT, van Beek EJ, Gray RD, Mills NL, Macnee W. Systemic elastin degradation in chronic obstructive pulmonary disease. Thorax 2012, 67(7):606-12. 10.1136/thoraxjnl-2011-200949, 22374923.
31. Kumagai K, Ohno I, Okada S. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma. J Immunol 1999, 162:4212-9.
32. Hoshino M, Nakamura Y, Sim J. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J Allergy Clin Immunol 1998, 102:783-8. 10.1016/S0091-6749(98)70018-1, 9819295.
33. Duvoix A, Dickens J, Haq I, Mannino D, Miller B, Tal-Singer R. Lomas DA 2012, Thorax: Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease, [Epub ahead of print].
34. Brims FJ, Chauhan AJ, Higgins B, Shute JK. Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids. Thorax 2009, 64(12):1037-43. 10.1136/thx.2009.114439, 19703828.
35. Van Rensen EL, Hiemstra PS, Rabe KF, Sterk PJ. Assessment of microvascular leakage via sputum induction: the role of substance P and neurokinin A in patients with asthma. Am J Respir Crit Care Med 2002, 165(9):1275-9. 10.1164/rccm.2110092, 11991878.
36. Wagers SS, Norton RJ, Rinaldi LM, Bates JH, Sobel BE, Irvin CG. Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness. J Clin Invest 2004, 114(1):104-11. 437962, 15232617.
37. Rubel C, Fernández GC, Dran G, Bompadre MB, MA I, Palermo MS. Fibrinogen promotes neutrophil activation and delays apoptosis. J Immunol 2001, 166(3):2002-10.
38. Willart MA, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht BN, Hammad H. Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med 2012, epub ahead of print.
39. Ingram JL, Rice AB, Geisenhoffer K, Madtes DK, Bonner JC. IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-R alpha. FASEB J 2004, 18(10):1132-4.
40. Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 2012, 122(1):70-9. 10.1172/JCI43713, 3248279, 22201681.
41. Simpson JL, Milne DG, Gibson PG. Neutrophilic asthma has different radiographic features to COPD and smokers. Respir Med 2009, 103(6):881-7. 10.1016/j.rmed.2008.12.013, 19168339.
42. Castro M, Rubin AS, Laviolette M. AIR2 study group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med 2010, 181(2):116-24. 10.1164/rccm.200903-0354OC, 3269231, 19815809.
43. Wahidi MM, Kraft M. Bronchial thermoplasty for severe asthma. Am J Respir Crit Care Med 2012, 185(7):709-14. 10.1164/rccm.201105-0883CI, 22077066.
44. Aysola RS, Hoffman EA, Gierada D, Wenzel S, Cook-Granroth J, Tarsi J, Zheng J, Schechtman KB, Ramkumar TP, Cochran R, Xueping E, Christie C, Newell J, Fain S, Altes TA, Castro M. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest 2008, 134(6):1183-91. 10.1378/chest.07-2779, 2859729, 18641116.