Genotoxicity of Cytolethal Distending Toxin (CDT) on isogenic human colorectal cell lines: Potential promoting effects for colorectal carcinogenesis

Frontiers in Cellular and Infection Microbiology

Volumn 6, Issue MAR, 2016, Pages

  Graillot, Vanessa ^a   Dormoy, Inge ^a   Dupuy, Jacques ^a   Shay, Jerry W ^b,c   Huc, Laurence ^a   Mirey, Gladys ^a   Vignard, Julien ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

APC; Colorectal cancer; Cytolethal distending toxin; DNA double strand breaks; Genotoxicity; KRAS; P53

Indexed keywords

APC PROTEIN; CYTOLETHAL DISTENDING TOXIN; KRAS PROTEIN; PEPTIDES AND PROTEINS; PROTEIN P53; UNCLASSIFIED DRUG; APC PROTEIN, HUMAN; BACTERIAL TOXIN; CARCINOGEN; KRAS PROTEIN, HUMAN; PROTEIN P21; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL PROLIFERATION ASSAY; CELL VIABILITY ASSAY; CLONOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DOUBLE STRANDED DNA BREAK; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; COLORECTAL TUMOR; DNA REPAIR; DRUG EFFECTS; EPITHELIUM CELL; ESCHERICHIA COLI; GENETICS; INTESTINE MUCOSA; PATHOGENICITY; PATHOLOGY; TUMOR CELL LINE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; APOPTOSIS; BACTERIAL TOXINS; CARCINOGENESIS; CARCINOGENS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; EPITHELIAL CELLS; ESCHERICHIA COLI; HUMANS; INTESTINAL MUCOSA; PROTO-ONCOGENE PROTEINS P21(RAS); TUMOR SUPPRESSOR PROTEIN P53;

EID: 85006228069     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2016.00034     Document Type: Article

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