Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

ACS Infectious Diseases

Volumn 2, Issue 8, 2016, Pages 579-591

  Kuhn, Misty L ^a,d   Alexander, Evan ^b   Minasov, George ^a   Page, Holland J ^d   Warwrzak, Zdzislaw ^e   Shuvalova, Ludmilla ^a   Flores, Kristin J ^a   Wilson, Daniel J ^c   Shi, Ce ^b   Aldrich, Courtney C ^b,c   Anderson, Wayne F ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d SAN FRANCISCO STATE UNIVERSITY   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

FadD32; fatty acyl AMP ligase; Mycobacterium tuberculosis; mycolic acid biosynthesis

Indexed keywords

ADENOSINE PHOSPHATE; BACTERIAL ENZYME; LIGAND; MYCOBACTERIUM TUBERCULOSIS FADD32 PROTEIN; UNCLASSIFIED DRUG;

ADENYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; FATTY ACID TRANSPORT; GENE INSERTION SEQUENCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STRUCTURE ANALYSIS;

EID: 85006210861     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.6b00082     Document Type: Article

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