Effects of vegetarian diets on blood lipids: A systematic review and meta-analysis of randomized controlled trials

Journal of the American Heart Association

Volumn 4, Issue 10, 2015, Pages

  Wang, Fenglei ^a   Zheng, Jusheng ^a   Yang, Bo ^a   Jiang, Jiajing ^a   Fu, Yuanqing ^a   Li, Duo ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Cholesterol; Diet; Lipoprotein lipids; Triglyceride; Vegetarian

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; BIOLOGICAL MARKER; LIPID;

AGE DISTRIBUTION; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL EFFECTIVENESS; DIETARY FIBER; HUMAN; LIPID BLOOD LEVEL; OBESITY; PRIORITY JOURNAL; SYSTEMATIC REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; VEGETARIAN DIET; WEIGHT REDUCTION; BLOOD; DIET THERAPY; DOWN REGULATION; DYSLIPIDEMIAS; META ANALYSIS; VEGETARIAN;

BIOMARKERS; DIET, VEGETARIAN; DOWN-REGULATION; DYSLIPIDEMIAS; HUMANS; LIPIDS; VEGETARIANS;

EID: 85006189044     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002408     Document Type: Article

References (51)

1. Okamura T. Dyslipidemia and cardiovascular disease: a series of epidemiologic studies in Japanese populations. J Epidemiol. 2010;20:259-265.
2. Ferdowsian HR, Barnard ND. Effects of plant-based diets on plasma lipids. Am J Cardiol. 2009;104:947-956.
3. Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet. 2014;384:626-635.
4. Expert Panel on Detection E. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285:2486-2497.
5. Ridker PM. LDL cholesterol: controversies and future therapeutic directions. Lancet. 2014;384:607-617.
6. Tenenbaum A, Fisman EZ. Fibrates are an essential part of modern antidyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction. Cardiovasc Diabetol. 2012;11:1475-2840.
7. Istvan ES, Deisenhofer J. Structural mechanism for statin inhibition of HMGCoA reductase. Science. 2001;292:1160-1164.
8. Ha V, Sievenpiper JL, de Souza RJ, Jayalath VH, Mirrahimi A, Agarwal A, Chiavaroli L, Mejia SB, Sacks FM, Di Buono M. Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials. Can Med Assoc J. 2014;186:E252-E262.
9. Jellinger PS, Smith DA, Mehta AE, Ganda O, Handelsman Y, Rodbard HW, Shepherd MD, Seibel JA. American association of clinical endocrinologists' guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocr Pract. 2012;18:1-78.
10. Li D. Effect of the vegetarian diet on non-communicable diseases. J Sci Food Agric. 2014;94:169-173.
11. Li D. Chemistry behind vegetarianism. J Agric Food Chem. 2011;59:777-784.
12. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, Okamura T, Miyamoto Y. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med. 2014;174:577-587.
13. Huang T, Yang B, Zheng J, Li G, Wahlqvist ML, Li D. Cardiovascular disease mortality and cancer incidence in vegetarians: a meta-analysis and systematic review. Ann Nutr Metab. 2012;60:233-240.
14. Li D, Sinclair A, Mann N, Turner A, Ball M, Kelly F, Abedin L, Wilson A. The association of diet and thrombotic risk factors in healthy male vegetarians and meat-eaters. Eur J Clin Nutr. 1999;53:612-619.
15. De Biase SG, Fernandes SFC, Gianini RJ, Duarte JLG. Vegetarian diet and cholesterol and triglycerides levels. Arq Bras Cardiol. 2007;88:35-39.
16. Barnard ND, Scialli AR, Bertron P, Hurlock D, Edmonds K, Talev L. Effectiveness of a low-fat vegetarian diet in altering serum lipids in healthy premenopausal women. Am J Cardiol. 2000;85:969-972.
17. Mishra S, Xu J, Agarwal U, Gonzales J, Levin S, Barnard ND. A multicenter randomized controlled trial of a plant-based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO study. Eur J Clin Nutr. 2013;67:718-724.
18. Ågren JJ, Tvrzicka E, Nenonen MT, Helve T, Hanninen O. Divergent changes in serum sterols during a strict uncooked vegan diet in patients with rheumatoid arthritis. Br J Nutr. 2001;85:137-139.
19. Barnard ND, Cohen J, Jenkins DJ, Turner-McGrievy G, Gloede L, Green A, Ferdowsian H. A low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74-wk clinical trial. Am J Clin Nutr. 2009;89(suppl):1S-9S.
20. Moher D, Liberati A, TetzlaffJ, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151:264-269.
21. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Available at: http://www.cochranehandbook.org. Accessed April 2, 2015.
22. Elbourne DR, Altman DG, Higgins JP, Curtin F, Worthington HV, Vail A. Metaanalyses involving cross-over trials: methodological issues. Int J Epidemiol. 2002;31:140-149.
23. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188.
24. Cooper RS, Goldberg RB, Trevisan M, Tsong Y, Liu K, Stamler J, Rubenstein A, Scanu AM. The selective lipid-lowering effect of vegetarianism on low density lipoproteins in a cross-over experiment. Atherosclerosis. 1982;44:293-305.
25. Kestin M, Rouse IL, Correll RA, Nestel PJ. Cardiovascular disease risk factors in free-living men: comparison of two prudent diets, one based on lactoovovegetarianism and the other allowing lean meat. Am J Clin Nutr. 1989;50:280-287.
26. Ling WH, Laitinen M, Hanninen O. Shifting from conventional diet to an uncooked vegan diet reversibly alters serum lipid and apolipoprotein levels. Nutr Res. 1992;12:1431-1440.
27. Nicholson AS, Sklar M, Barnard ND, Gore S, Sullivan R, Browning S. Toward improved management of NIDDM: a randomized, controlled, pilot intervention using a lowfat, vegetarian diet. Prev Med. 1999;29:87-91.
28. Burke LE, Hudson AG, Warziski MT, Styn MA, Music E, Elci OU, Sereika SM. Effects of a vegetarian diet and treatment preference on biochemical and dietary variables in overweight and obese adults: a randomized clinical trial. Am J Clin Nutr. 2007;86:588-596.
29. Elkan AC, Sjoberg B, Kolsrud B, Ringertz B, Hafstrom I, Frostegard J. Glutenfree vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study. Arthritis Res Ther. 2008;10:R34.
30. Kahleova H, Matoulek M, Malinska H, Oliyarnik O, Kazdova L, Neskudla T, Skoch A, Hajek M, Hill M, Kahle M, Pelikanova T. Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with type 2 diabetes. Diabet Med. 2011;28:549-559.
31. Anderson TJ, Grégoire J, Hegele RA, Couture P, Mancini GB, McPherson R, Francis GA, Poirier P, Lau DC, Grover S, Genest J Jr, Carpentier AC, Dufour R, Gupta M, Ward R, Leiter LA, Lonn E, Ng DS, Pearson GJ, Yates GM, Stone JA, Ur E. 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol. 2013;29:151-167.
32. Robinson F, Hackett AF, Billington D, Stratton G. Changing from a mixed to self-selected vegetarian diet-influence on blood lipids. J Hum Nutr Diet. 2002;15:323-329.
33. Papadaki A, Vardavas C, Hatzis C, Kafatos A. Calcium, nutrient and food intake of Greek Orthodox Christian monks during a fasting and non-fasting week. Public Health Nutr. 2008;11:1022-1029.
34. Zhang Z, Wang J, Chen S, Wei Z, Li Z, Zhao S, Lu W. Comparison of vegetarian diets and omnivorous diets on plasma level of HDL-c: a meta-analysis. PLoS One. 2014;9:e92609.
35. Zhang Z, Ma G, Chen S, Li Z, Xia E, Sun Y, Yang F, Zheng L, Feng X. Comparison of plasma triacylglycerol levels in vegetarians and omnivores: a meta-analysis. Nutrition. 2013;29:426-430.
36. Miettinen TA. Cholesterol production in obesity. Circulation. 1971;44:842-850.
37. VanPatten S, Ranginani N, Shefer S, Nguyen LB, Rossetti L, Cohen DE. Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance. Am J Physiol Gastrointest Liver Physiol. 2001;281: G393-G404.
38. Scarpace PJ, Zhang Y. Leptin resistance: a prediposing factor for diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2009;296:R493-R500.
39. Porta N, Bonet C, Cobo E. Discordance between reported intention-to-treat and per protocol analyses. J Clin Epidemiol. 2007;60:663-669.
40. Schwingshackl L, Hoffmann G. Comparison of effects of long-term low-fat vs high-fat diets on blood lipid levels in overweight or obese patients: a systematic review and meta-analysis. J Acad Nutr Diet. 2013;113:1640-1661.
41. Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, Hennekens CH, Willett WC. Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med. 1997;337:1491-1499.
42. Craig WJ. Nutrition concerns and health effects of vegetarian diets. Nutr Clin Pract. 2010;25:613-620.
43. Uddin M, Sarker M, Islam Z, Ferdosh S, Akanda M, Haque J, Easmin M, Shamsudin B, Hadijah S, Yunus KB. Phytosterols and their extraction from various plant matrices using supercritical carbon dioxide: a review. J Sci Food Agric. 2015;95:1385-1394.
44. Van Hung P. Phenolic compounds of cereals and their antioxidant capacity. Crit Rev Food Sci Nutr. 2014; doi:10.1080/10408398.2012.708909 [Epub ahead of print].
45. Chávez-Santoscoy RA, Gutiérrez-Uribe JA, Serna-Saldívar SO. Effect of flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats as cholesterol micelle disruptors. Plant Foods Hum Nutr. 2013;68:416-423.
46. Liu L, Yeh Y. Inhibition of cholesterol biosynthesis by organosulfur compounds derived from garlic. Lipids. 2000;35:197-203.
47. Desroches S, Paradis M, Pérusse M, Archer WR, Bergeron J, Couture P, Bergeron N, Lamarche B. Apolipoprotein AI, A-II, And VLDL-B-100 metabolism in men comparison of a low-fat diet and a high-monounsaturated fatty acid diet. J Lipid Res. 2004;45:2331-2338.
48. Rader DJ, Hovingh GK. HDL and cardiovascular disease. Lancet. 2014;384:618-625.
49. Ornish D, Scherwitz LW, Billings JH, Gould KL, Merritt TA, Sparler S, Armstrong WT, Ports TA, Kirkeeide RL, Hogeboom C. Intensive lifestyle changes for reversal of coronary heart disease. JAMA. 1998;280:2001-2007.
50. Dattilo AM, Kris-Etherton PM. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr. 1992;56:320-328.
51. Tolonen H, Wolf H, Jakovljevic D, Kuulasmaa K. Review of surveys for risk factors of major chronic diseases and comparability of the results. European Health Risk Monitoring (EHRM) Project [text on the Internet]. Oslo, 2002. Available at: http://www.thl.fi/publications/ehrm/product1/title.htm. Accessed April 30, 2015.