K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

Nature Communications

Volumn 7, Issue , 2016, Pages

  Wu, Han Tsang ^a   Kuo, Yi Chih ^a   Hung, Jung Jyh ^b,c   Huang, Chi Hung ^d   Chen, Wei Yi ^b   Chou, Teh Ying ^b,c   Chen, Yeh ^e   Chen, Yi Ju ^f   Chen, Yu Ju ^f   Cheng, Wei Chung ^a   Teng, Shu Chun ^g   Wu, Kou Juey ^a,h  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^d Taiwan Advance Biopharm (TABP)   (Taiwan)

^e HUNGKUANG UNIVERSITY   (Taiwan)

^f INSTITUTE OF CHEMISTRY   (Taiwan)

^g NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^h CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DEUBIQUITINASE; HISTONE H3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LYSINE; BONE SIALOPROTEIN (35-62), HUMAN; HISTONE; HUWE1 PROTEIN, HUMAN; OXYGEN; PEPTIDE FRAGMENT; SIALOGLYCOPROTEIN; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN CARBOXYL TERMINAL HYDROLASE 7; UBIQUITIN PROTEIN LIGASE; USP7 PROTEIN, HUMAN;

AMINO ACID; CELLS AND CELL COMPONENTS; CHEMICAL REACTION; ENZYME ACTIVITY; GENE; HYPOXIA; PROTEIN; STABILIZATION; TUMOR;

ARTICLE; CANCER CELL LINE; CONTROLLED STUDY; EMBRYO; EPITHELIAL MESENCHYMAL TRANSITION; GENE SILENCING; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HYPOXIA; MALE; METASTASIS; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TUMOR GROWTH; UBIQUITINATION; ACETYLATION; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; MOLECULAR MODEL; PATHOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE;

ACETYLATION; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MODELS, MOLECULAR; OXYGEN; PEPTIDE FRAGMENTS; PROMOTER REGIONS, GENETIC; PROTEIN CONFORMATION; SIALOGLYCOPROTEINS; TANDEM MASS SPECTROMETRY; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITIN-SPECIFIC PEPTIDASE 7; UBIQUITINATION;

EID: 85006139130     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13644     Document Type: Article

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