HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized

FEBS Letters

Volumn 579, Issue 21, 2005, Pages 4867-4872

  Lee, Hye Jin ^a   Kim, Myung Sun ^a   Kim, Yu Kyung ^a   Oh, Yu Kyoung ^a   Baek, Kwang Hyun ^a  

^a CHA University   (South Korea)

Author keywords

Deubiquitinating enzyme; Dimerization; Herpes virus associated ubiquitin specific protease; Polyneddylation; Polyubiquitination; Ubiquitin specific protease 7

Indexed keywords

BETA GALACTOSIDASE; HERPES VIRUS ASSOCIATED UBIQUITIN SPECIFIC PROTEASE; MUTANT PROTEIN; PROTEIN P53; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DIMERIZATION; ENZYME DEGRADATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; UBIQUITINATION;

ANIMALS; APOPTOSIS; CELL LINE; DIMERIZATION; ENDOPEPTIDASES; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RATS; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

HERPES; HERPESVIRIDAE;

EID: 24044511553     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.07.048     Document Type: Article

References (23)

1. M.H. Glickman, and A. Ciechanover The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Physiol. Rev. 82 2002 373 428
2. A. Ciechanover The ubiquitin-proteasome pathway: on protein death and cell life EMBO J. 17 1998 7151 7160
3. A. Hershko, and A. Ciechanover The ubiquitin system Annu. Rev. Biochem. 67 1998 425 479
4. K.H. Baek Conjugation and deconjugation of ubiquitin regulating the destiny of proteins Exp. Mol. Med. 35 2003 1 7
5. C.M. Pickart Mechanisms underlying ubiquitination Annu. Rev. Biochem. 70 2001 503 533
6. K.D. Wilkinson Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome Semin. Cell. Dev. Biol. 11 2000 141 148
7. M.H. Kubbutat, S.N. Jones, and K.H. Vousden Regulation of p53 stability by Mdm2 Nature 387 1997 299 303
8. R. Honda, H. Tanaka, and H. Yasuda Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 FEBS Lett. 420 1997 25 27
9. R. Honda, and H. Yasuda Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase Oncogene 19 2000 1473 1476
10. Z. Lai, K.V. Ferry, M.A. Diamond, K.E. Wee, Y.B. Kim, J. MA, T. Yang, P. Benfield, R.A. Copeland, and K.R. Auger Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization J. Biol. Chem. 276 2001 31357 31367
11. S.R. Grossman, M.E. Deato, C. Brignone, H.M. Chn, A.L. Kung, H. Tagami, Y. Nakatani, and D.M. Livingston Polyubiquitination of p53 by a ubiquitin ligase activity of p300 Science 300 2003 342 344
12. M. Li, D. Chen, A. Shiloh, J. Luo, A.Y. Nikolaev, J. Qin, and W. Gu Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization Nature 416 2002 648 653
13. M. Li, C.L. Brooks, N. Kon, and W. Gu A dynamic role of HAUSP in the p53-Mdm2 pathway Mol. Cell 13 2004 879 886
14. J.M. Cummins, and B. Vogelstein HAUSP is required for p53 destabilization Cell Cycle 3 2004 689 692
15. S.K. Lim, J.M. Shin, Y.S. Kim, and K.H. Baek Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination Int. J. Oncol. 24 2004 357 364
16. S. Hong, S.J. Kim, S. Ka, I. Choi, and S. Kang USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product Mol. Cell. Neurosci. 20 2002 298 306
17. E. Meulmeester, M.M. Maurice, C. Boutell, A.F. Teunisse, H. Ovaa, T.E. Abraham, R.W. Dirks, and A.G. Jochemsen Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 Mol. Cell 18 2005 565 576
18. K.H. Baek, M.S. Kim, Y.S. Kim, J.M. Shin, and H.K. Choi DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes J. Biol. Chem. 279 2004 2368 2376
19. M.S. Kim, Y.K. Kim, Y.S. Kim, M. Seong, J.K. Choi, and K.H. Baek Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated Biochem. Biophys. Res. Commun. 330 2005 797 804
20. C.G. Maki, J.M. Huibregtse, and P.M. Howley In vivo ubiquitination and proteasome-mediated degradation of p53 Cancer Res. 56 1996 2649 2654
21. M. Gostissa, A. Hengstermann, V. Fogal, P. Sandy, S.E. Schwarz, M. Scheffner, and G. Del Sal Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1 EMBO J. 18 1999 6462 6471
22. M.S. Rodriguez, J.M. Desterro, S. Lain, C.A. Midgley, D.P. Lane, and R.T. Hay SUMO-1 modification activates the transcriptional response of p53 EMBO J. 18 1999 6455 6461
23. D.P. Xirodimas, M.K. Saville, J.C. Bourdon, R.T. Hay, and D.P. Lane Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity Cell 118 2004 83 97