Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

Nature Communications

Volumn 7, Issue , 2016, Pages

  Kempf, Henning ^a   Olmer, Ruth ^a,b   Haase, Alexandra ^a   Franke, Annika ^a   Bolesani, Emiliano ^a   Schwanke, Kristin ^a   Robles Diaz, Diana ^a   Coffee, Michelle ^a   Göhring, Gudrun ^a   Dräger, Gerald ^a,c   Pötz, Oliver ^d   Joos, Thomas ^d   Martinez Hackert, Erik ^e   Haverich, Axel ^a   Buettner, Falk F R ^a   Martin, Ulrich ^a,b   Zweigerdt, Robert ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b German Center for Lung Research   (Germany)

^c LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ACTININ; CD56 ANTIGEN; CER1 PROTEIN; CERBERUS 1 PROTEIN; CHEMOKINE RECEPTOR CXCR4; EPITHELIAL CELL ADHESION MOLECULE; GREEN FLUORESCENT PROTEIN; LEFT RIGHT DETERMINATION FACTOR; LEFT RIGHT DETERMINATION FACTOR 1; MYOSIN HEAVY CHAIN; NERVE CELL ADHESION MOLECULE; NODAL SIGNALING PROTEIN; STEM CELL FACTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR MSX2; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PAX7; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA; TROPONIN T; UNCLASSIFIED DRUG; VIMENTIN; WNT PROTEIN; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA; TRANSCRIPTOME;

CELLS AND CELL COMPONENTS; DIFFERENTIATION; EMBRYO; EMBRYONIC DEVELOPMENT; FUNCTIONAL ROLE; GENE EXPRESSION; NUMERICAL MODEL; OPTIMIZATION;

ANTERIOR POSTERIOR AXIS; ARTICLE; BULK CELL DENSITY; CELL DENSITY; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL VOLUME; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; INDUCED PLURIPOTENT STEM CELL; MESENDODERM; MESODERM; MICROENVIRONMENT; NUCLEAR REPROGRAMMING; PARACRINE SIGNALING; PRIMITIVE STREAK; PROTEIN EXPRESSION; UPREGULATION; WNT SIGNALING PATHWAY; CELL COUNT; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PLURIPOTENT STEM CELL; PROTEIN MICROARRAY; SIGNAL TRANSDUCTION;

CELL COUNT; GENE EXPRESSION REGULATION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLURIPOTENT STEM CELLS; PROTEIN ARRAY ANALYSIS; PYRIDINES; PYRIMIDINES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS;

EID: 85006116298     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13602     Document Type: Article

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