-
1
-
-
84928254065
-
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
-
McGranahan, N. et al. Clonal status of actionable driver events and the timing of mutational processes in cancer evolution. Sci. Transl. Med 7, 283ra254 (2015).
-
(2015)
Sci. Transl. Med
, vol.7
, pp. 283ra254
-
-
McGranahan, N.1
-
2
-
-
84952310964
-
SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution
-
Miller, C. A. et al. SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution. PLoS Comput. Biol. 10, e1003665 (2014).
-
(2014)
PLoS Comput. Biol
, vol.10
, pp. e1003665
-
-
Miller, C.A.1
-
3
-
-
84884365015
-
The causes and consequences of genetic heterogeneity in cancer evolution
-
Burrell, R. A., McGranahan, N., Bartek, J. & Swanton, C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501, 338-345 (2013).
-
(2013)
Nature
, vol.501
, pp. 338-345
-
-
Burrell, R.A.1
McGranahan, N.2
Bartek, J.3
Swanton, C.4
-
4
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
Diaz, L. A. et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537-540 (2012).
-
(2012)
Nature
, vol.486
, pp. 537-540
-
-
Diaz, L.A.1
-
5
-
-
84914112343
-
Tumour heterogeneity and the evolution of polyclonal drug resistance
-
Burrell, R. A. & Swanton, C. Tumour heterogeneity and the evolution of polyclonal drug resistance. Mol. Oncol. 8, 1095-1111 (2014).
-
(2014)
Mol. Oncol
, vol.8
, pp. 1095-1111
-
-
Burrell, R.A.1
Swanton, C.2
-
6
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem, E. et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 25, 1658-1664 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
-
7
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham, D. et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351, 337-345 (2004).
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
-
8
-
-
84908431348
-
Resistance to anti-EGFR therapy in colorectal cancer: From heterogeneity to convergent evolution
-
Misale, S., Di Nicolantonio, F., Sartore-Bianchi, A., Siena, S. & Bardelli, A. Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution. Cancer Discov. 4, 1269-1280 (2014).
-
(2014)
Cancer Discov
, vol.4
, pp. 1269-1280
-
-
Misale, S.1
Di Nicolantonio, F.2
Sartore-Bianchi, A.3
Siena, S.4
Bardelli, A.5
-
9
-
-
84965190416
-
Overcoming resistance to anti-EGFR therapy in colorectal cancer
-
Dienstmann, R., Salazar, R. & Tabernero, J. Overcoming resistance to anti-EGFR therapy in colorectal cancer. Am. Soc. Clin. Oncol. Educ. Book 35, e149-e156 (2015).
-
(2015)
Am. Soc. Clin. Oncol. Educ. Book
, vol.35
, pp. e149-e156
-
-
Dienstmann, R.1
Salazar, R.2
Tabernero, J.3
-
10
-
-
84856717005
-
Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer
-
Montagut, C. et al. Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer. Nat. Med. 18, 221-223 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 221-223
-
-
Montagut, C.1
-
11
-
-
84932606172
-
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer
-
Arena, S. et al. Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer. Clin. Cancer Res. 21, 2157-2166 (2015).
-
(2015)
Clin. Cancer Res
, vol.21
, pp. 2157-2166
-
-
Arena, S.1
-
12
-
-
84926431987
-
Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment
-
Morelli, M. P. et al. Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment. Ann. Oncol. 26, 731-736 (2015).
-
(2015)
Ann. Oncol
, vol.26
, pp. 731-736
-
-
Morelli, M.P.1
-
13
-
-
84936748494
-
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
-
Siravegna, G. et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat. Med. 21, 827 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 827
-
-
Siravegna, G.1
-
14
-
-
84937761544
-
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
-
Bhang, H. E. et al. Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. Nat. Med. 21, 440-448 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 440-448
-
-
Bhang, H.E.1
-
15
-
-
84991530848
-
Lentiviral and targeted cellular barcoding reveals ongoing clonal dynamics of cell lines in vitro and in vivo
-
Porter, S. N., Baker, L. C., Mittelman, D. & Porteus, M. H. Lentiviral and targeted cellular barcoding reveals ongoing clonal dynamics of cell lines in vitro and in vivo. Genome Biol. 15, R75 (2014).
-
(2014)
Genome Biol.
, vol.15
, pp. R75
-
-
Porter, S.N.1
Baker, L.C.2
Mittelman, D.3
Porteus, M.H.4
-
16
-
-
84908441752
-
TGFa and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells
-
Hobor, S. et al. TGFa and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells. Clin. Cancer Res. 20, 6429-6438 (2014).
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 6429-6438
-
-
Hobor, S.1
-
17
-
-
70349331678
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
-
Yun, J. et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 325, 1555-1559 (2009).
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.1
-
18
-
-
84955326448
-
The emerging hallmarks of cancer metabolism
-
Pavlova, N. N. & Thompson, C. B. The emerging hallmarks of cancer metabolism. Cell Metab. 23, 27-47 (2016).
-
(2016)
Cell Metab
, vol.23
, pp. 27-47
-
-
Pavlova, N.N.1
Thompson, C.B.2
-
19
-
-
84937143954
-
Metastatic colorectal cancer: Current state and future directions
-
Fakih, M. G. Metastatic colorectal cancer: current state and future directions. J. Clin. Oncol. 33, 1809-1824 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 1809-1824
-
-
Fakih, M.G.1
-
20
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
Misale, S. et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486, 532-536 (2012).
-
(2012)
Nature
, vol.486
, pp. 532-536
-
-
Misale, S.1
-
21
-
-
84891808183
-
The S492R EGFR ectodomain mutation is never detected in KRAS wild type colorectal carcinoma before exposure to EGFR monoclonal antibodies
-
Esposito, C. et al. The S492R EGFR ectodomain mutation is never detected in KRAS wild type colorectal carcinoma before exposure to EGFR monoclonal antibodies. Cancer Biol. Ther. 14, 1143-1146 (2013).
-
(2013)
Cancer Biol. Ther
, vol.14
, pp. 1143-1146
-
-
Esposito, C.1
-
22
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
Zhang, J., Yang, P. L. & Gray, N. S. Targeting cancer with small molecule kinase inhibitors. Nat. Rev. Cancer 9, 28-39 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
23
-
-
77649175453
-
Genomic instability-an evolving hallmark of cancer
-
Negrini, S., Gorgoulis, V. G. & Halazonetis, T. D. Genomic instability-an evolving hallmark of cancer. Nat. Rev. Mol. Cell. Biol. 11, 220-228 (2010).
-
(2010)
Nat. Rev. Mol. Cell. Biol
, vol.11
, pp. 220-228
-
-
Negrini, S.1
Gorgoulis, V.G.2
Halazonetis, T.D.3
-
24
-
-
20844460619
-
A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
-
Chen, L. L. et al. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. 64, 5913-5919 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 5913-5919
-
-
Chen, L.L.1
-
25
-
-
84905366894
-
Acquired resistance to TKIs in solid tumours: Learning from lung cancer
-
Camidge, D. R., Pao, W. & Sequist, L. V. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat. Rev. Clin. Oncol. 11, 473-481 (2014).
-
(2014)
Nat. Rev. Clin. Oncol
, vol.11
, pp. 473-481
-
-
Camidge, D.R.1
Pao, W.2
Sequist, L.V.3
-
26
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao, W. et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, e73 (2005).
-
(2005)
PLoS Med
, vol.2
, pp. e73
-
-
Pao, W.1
-
27
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007).
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
-
28
-
-
84878862323
-
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
-
Bardelli, A. et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 3, 658-673 (2013).
-
(2013)
Cancer Discov
, vol.3
, pp. 658-673
-
-
Bardelli, A.1
-
29
-
-
80052591747
-
Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
-
Yonesaka, K. et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci. Transl. Med. 3, 99ra86 (2011).
-
(2011)
Sci. Transl. Med
, vol.3
, pp. 99ra86
-
-
Yonesaka, K.1
-
30
-
-
84896078397
-
Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
-
Misale, S. et al. Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer. Sci. Transl. Med. 6, 224ra226 (2014).
-
(2014)
Sci. Transl. Med
, vol.6
, pp. 224ra226
-
-
Misale, S.1
-
31
-
-
77449130761
-
Microsatellite instability in colorectal cancer
-
Boland, C. R. & Goel, A. Microsatellite instability in colorectal cancer. Gastroenterology 138, 2073-2087 (2010).
-
(2010)
Gastroenterology
, vol.138
, pp. 2073-2087
-
-
Boland, C.R.1
Goel, A.2
-
32
-
-
84903484926
-
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer
-
Mouradov, D. et al. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Res. 74, 3238-3247 (2014).
-
(2014)
Cancer Res
, vol.74
, pp. 3238-3247
-
-
Mouradov, D.1
-
33
-
-
84894189683
-
Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer
-
Kahlert, C. et al. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869-3875 (2014).
-
(2014)
J. Biol. Chem
, vol.289
, pp. 3869-3875
-
-
Kahlert, C.1
-
34
-
-
84901842265
-
Double-stranded DNA in exosomes: A novel biomarker in cancer detection
-
Thakur, B. K. et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 24, 766-769 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 766-769
-
-
Thakur, B.K.1
-
35
-
-
76549132066
-
Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
-
Garcia-Olmo, D. C. et al. Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res. 70, 560-567 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 560-567
-
-
Garcia-Olmo, D.C.1
-
36
-
-
84982684991
-
Molecular landscape of acquired resistance to targeted therapy combinations in BRAF-mutant colorectal cancer
-
Oddo, D. et al. Molecular landscape of acquired resistance to targeted therapy combinations in BRAF-mutant colorectal cancer. Cancer Res. 76, 4504-4515 (2016).
-
(2016)
Cancer Res
, vol.76
, pp. 4504-4515
-
-
Oddo, D.1
-
37
-
-
57849117384
-
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
-
Eisenhauer, E. A. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
-
(2009)
Eur. J. Cancer
, vol.45
, pp. 228-247
-
-
Eisenhauer, E.A.1
-
38
-
-
84893347899
-
Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation
-
Pietrantonio, F. et al. Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation. Ann. Oncol. 25, 404-408 (2014).
-
(2014)
Ann. Oncol
, vol.25
, pp. 404-408
-
-
Pietrantonio, F.1
-
39
-
-
84921946952
-
RAS testing of colorectal carcinoma-a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group
-
Wong, N. A. et al. RAS testing of colorectal carcinoma-a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group. J. Clin. Pathol. 67, 751-757 (2014).
-
(2014)
J. Clin. Pathol
, vol.67
, pp. 751-757
-
-
Wong, N.A.1
-
40
-
-
0036370361
-
Generation of HIV-1 derived lentiviral vectors
-
Follenzi, A. & Naldini, L. Generation of HIV-1 derived lentiviral vectors. Methods Enzymol. 346, 454-465 (2002).
-
(2002)
Methods Enzymol
, vol.346
, pp. 454-465
-
-
Follenzi, A.1
Naldini, L.2
-
41
-
-
0021910637
-
A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer
-
Whitehead, R. H., Macrae, F. A., St Sohn, D. J. & Ma, J. A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer. J. Natl Cancer Inst. 74, 759-765 (1985).
-
(1985)
J. Natl Cancer Inst
, vol.74
, pp. 759-765
-
-
Whitehead, R.H.1
Macrae, F.A.2
St Sohn, D.J.3
Ma, J.4
-
42
-
-
0036226603
-
BLAT-the BLAST-like alignment tool
-
Kent, W. J. BLAT-the BLAST-like alignment tool. Genome Res. 12, 656-664 (2002).
-
(2002)
Genome Res
, vol.12
, pp. 656-664
-
-
Kent, W.J.1
-
43
-
-
0025183708
-
Basic local alignment search tool
-
Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403-410 (1990).
-
(1990)
J. Mol. Biol
, vol.215
, pp. 403-410
-
-
Altschul, S.F.1
Gish, W.2
Miller, W.3
Myers, E.W.4
Lipman, D.J.5
-
44
-
-
77949587649
-
Fast and accurate long-read alignment with Burrows-Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589-595 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 589-595
-
-
Li, H.1
Durbin, R.2
-
45
-
-
68549104404
-
The Sequence Alignment/Map format and SAMtools
-
Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 2078-2079
-
-
Li, H.1
|