메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

(22)  Van Emburgh, Beth O a,b,c   Arena, Sabrina a,c   Siravegna, Giulia a,c   Lazzari, Luca a,c   Crisafulli, Giovanni a,c   Corti, Giorgio a   Mussolin, Benedetta a   Baldi, Federica a,c   Buscarino, Michela a   Bartolini, Alice a   Valtorta, Emanuele d   Vidal, Joana e   Bellosillo, Beatriz e   Germano, Giovanni a   Pietrantonio, Filippo f   Ponzetti, Agostino g   Albanell, Joan e   Siena, Salvatore d,h   Sartore Bianchi, Andrea d   Di Nicolantonio, Federica a,c   more..


Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; CHLOROPLAST DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; FIRTECAN; GENOMIC DNA; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; PANITUMUMAB; IMMUNOLOGICAL ANTINEOPLASTIC AGENT;

EID: 85006074206     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13665     Document Type: Article
Times cited : (169)

References (45)
  • 1
    • 84928254065 scopus 로고    scopus 로고
    • Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
    • McGranahan, N. et al. Clonal status of actionable driver events and the timing of mutational processes in cancer evolution. Sci. Transl. Med 7, 283ra254 (2015).
    • (2015) Sci. Transl. Med , vol.7 , pp. 283ra254
    • McGranahan, N.1
  • 2
    • 84952310964 scopus 로고    scopus 로고
    • SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution
    • Miller, C. A. et al. SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution. PLoS Comput. Biol. 10, e1003665 (2014).
    • (2014) PLoS Comput. Biol , vol.10 , pp. e1003665
    • Miller, C.A.1
  • 3
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell, R. A., McGranahan, N., Bartek, J. & Swanton, C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501, 338-345 (2013).
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 4
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz, L. A. et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537-540 (2012).
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz, L.A.1
  • 5
    • 84914112343 scopus 로고    scopus 로고
    • Tumour heterogeneity and the evolution of polyclonal drug resistance
    • Burrell, R. A. & Swanton, C. Tumour heterogeneity and the evolution of polyclonal drug resistance. Mol. Oncol. 8, 1095-1111 (2014).
    • (2014) Mol. Oncol , vol.8 , pp. 1095-1111
    • Burrell, R.A.1    Swanton, C.2
  • 6
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem, E. et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 25, 1658-1664 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1
  • 7
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham, D. et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351, 337-345 (2004).
    • (2004) N. Engl. J. Med , vol.351 , pp. 337-345
    • Cunningham, D.1
  • 8
    • 84908431348 scopus 로고    scopus 로고
    • Resistance to anti-EGFR therapy in colorectal cancer: From heterogeneity to convergent evolution
    • Misale, S., Di Nicolantonio, F., Sartore-Bianchi, A., Siena, S. & Bardelli, A. Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution. Cancer Discov. 4, 1269-1280 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 1269-1280
    • Misale, S.1    Di Nicolantonio, F.2    Sartore-Bianchi, A.3    Siena, S.4    Bardelli, A.5
  • 10
    • 84856717005 scopus 로고    scopus 로고
    • Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer
    • Montagut, C. et al. Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer. Nat. Med. 18, 221-223 (2012).
    • (2012) Nat. Med , vol.18 , pp. 221-223
    • Montagut, C.1
  • 11
    • 84932606172 scopus 로고    scopus 로고
    • Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer
    • Arena, S. et al. Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer. Clin. Cancer Res. 21, 2157-2166 (2015).
    • (2015) Clin. Cancer Res , vol.21 , pp. 2157-2166
    • Arena, S.1
  • 12
    • 84926431987 scopus 로고    scopus 로고
    • Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment
    • Morelli, M. P. et al. Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment. Ann. Oncol. 26, 731-736 (2015).
    • (2015) Ann. Oncol , vol.26 , pp. 731-736
    • Morelli, M.P.1
  • 13
    • 84936748494 scopus 로고    scopus 로고
    • Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
    • Siravegna, G. et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat. Med. 21, 827 (2015).
    • (2015) Nat. Med , vol.21 , pp. 827
    • Siravegna, G.1
  • 14
    • 84937761544 scopus 로고    scopus 로고
    • Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
    • Bhang, H. E. et al. Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. Nat. Med. 21, 440-448 (2015).
    • (2015) Nat. Med , vol.21 , pp. 440-448
    • Bhang, H.E.1
  • 15
    • 84991530848 scopus 로고    scopus 로고
    • Lentiviral and targeted cellular barcoding reveals ongoing clonal dynamics of cell lines in vitro and in vivo
    • Porter, S. N., Baker, L. C., Mittelman, D. & Porteus, M. H. Lentiviral and targeted cellular barcoding reveals ongoing clonal dynamics of cell lines in vitro and in vivo. Genome Biol. 15, R75 (2014).
    • (2014) Genome Biol. , vol.15 , pp. R75
    • Porter, S.N.1    Baker, L.C.2    Mittelman, D.3    Porteus, M.H.4
  • 16
    • 84908441752 scopus 로고    scopus 로고
    • TGFa and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells
    • Hobor, S. et al. TGFa and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells. Clin. Cancer Res. 20, 6429-6438 (2014).
    • (2014) Clin. Cancer Res , vol.20 , pp. 6429-6438
    • Hobor, S.1
  • 17
    • 70349331678 scopus 로고    scopus 로고
    • Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
    • Yun, J. et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 325, 1555-1559 (2009).
    • (2009) Science , vol.325 , pp. 1555-1559
    • Yun, J.1
  • 18
    • 84955326448 scopus 로고    scopus 로고
    • The emerging hallmarks of cancer metabolism
    • Pavlova, N. N. & Thompson, C. B. The emerging hallmarks of cancer metabolism. Cell Metab. 23, 27-47 (2016).
    • (2016) Cell Metab , vol.23 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 19
    • 84937143954 scopus 로고    scopus 로고
    • Metastatic colorectal cancer: Current state and future directions
    • Fakih, M. G. Metastatic colorectal cancer: current state and future directions. J. Clin. Oncol. 33, 1809-1824 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. 1809-1824
    • Fakih, M.G.1
  • 20
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • Misale, S. et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486, 532-536 (2012).
    • (2012) Nature , vol.486 , pp. 532-536
    • Misale, S.1
  • 21
    • 84891808183 scopus 로고    scopus 로고
    • The S492R EGFR ectodomain mutation is never detected in KRAS wild type colorectal carcinoma before exposure to EGFR monoclonal antibodies
    • Esposito, C. et al. The S492R EGFR ectodomain mutation is never detected in KRAS wild type colorectal carcinoma before exposure to EGFR monoclonal antibodies. Cancer Biol. Ther. 14, 1143-1146 (2013).
    • (2013) Cancer Biol. Ther , vol.14 , pp. 1143-1146
    • Esposito, C.1
  • 22
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang, J., Yang, P. L. & Gray, N. S. Targeting cancer with small molecule kinase inhibitors. Nat. Rev. Cancer 9, 28-39 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 24
    • 20844460619 scopus 로고    scopus 로고
    • A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
    • Chen, L. L. et al. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. 64, 5913-5919 (2004).
    • (2004) Cancer Res , vol.64 , pp. 5913-5919
    • Chen, L.L.1
  • 25
    • 84905366894 scopus 로고    scopus 로고
    • Acquired resistance to TKIs in solid tumours: Learning from lung cancer
    • Camidge, D. R., Pao, W. & Sequist, L. V. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat. Rev. Clin. Oncol. 11, 473-481 (2014).
    • (2014) Nat. Rev. Clin. Oncol , vol.11 , pp. 473-481
    • Camidge, D.R.1    Pao, W.2    Sequist, L.V.3
  • 26
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao, W. et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, e73 (2005).
    • (2005) PLoS Med , vol.2 , pp. e73
    • Pao, W.1
  • 27
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007).
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1
  • 28
    • 84878862323 scopus 로고    scopus 로고
    • Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
    • Bardelli, A. et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 3, 658-673 (2013).
    • (2013) Cancer Discov , vol.3 , pp. 658-673
    • Bardelli, A.1
  • 29
    • 80052591747 scopus 로고    scopus 로고
    • Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
    • Yonesaka, K. et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci. Transl. Med. 3, 99ra86 (2011).
    • (2011) Sci. Transl. Med , vol.3 , pp. 99ra86
    • Yonesaka, K.1
  • 30
    • 84896078397 scopus 로고    scopus 로고
    • Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
    • Misale, S. et al. Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer. Sci. Transl. Med. 6, 224ra226 (2014).
    • (2014) Sci. Transl. Med , vol.6 , pp. 224ra226
    • Misale, S.1
  • 31
    • 77449130761 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer
    • Boland, C. R. & Goel, A. Microsatellite instability in colorectal cancer. Gastroenterology 138, 2073-2087 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 2073-2087
    • Boland, C.R.1    Goel, A.2
  • 32
    • 84903484926 scopus 로고    scopus 로고
    • Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer
    • Mouradov, D. et al. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Res. 74, 3238-3247 (2014).
    • (2014) Cancer Res , vol.74 , pp. 3238-3247
    • Mouradov, D.1
  • 33
    • 84894189683 scopus 로고    scopus 로고
    • Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer
    • Kahlert, C. et al. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869-3875 (2014).
    • (2014) J. Biol. Chem , vol.289 , pp. 3869-3875
    • Kahlert, C.1
  • 34
    • 84901842265 scopus 로고    scopus 로고
    • Double-stranded DNA in exosomes: A novel biomarker in cancer detection
    • Thakur, B. K. et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 24, 766-769 (2014).
    • (2014) Cell Res , vol.24 , pp. 766-769
    • Thakur, B.K.1
  • 35
    • 76549132066 scopus 로고    scopus 로고
    • Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
    • Garcia-Olmo, D. C. et al. Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res. 70, 560-567 (2010).
    • (2010) Cancer Res , vol.70 , pp. 560-567
    • Garcia-Olmo, D.C.1
  • 36
    • 84982684991 scopus 로고    scopus 로고
    • Molecular landscape of acquired resistance to targeted therapy combinations in BRAF-mutant colorectal cancer
    • Oddo, D. et al. Molecular landscape of acquired resistance to targeted therapy combinations in BRAF-mutant colorectal cancer. Cancer Res. 76, 4504-4515 (2016).
    • (2016) Cancer Res , vol.76 , pp. 4504-4515
    • Oddo, D.1
  • 37
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer, E. A. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
    • (2009) Eur. J. Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1
  • 38
    • 84893347899 scopus 로고    scopus 로고
    • Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation
    • Pietrantonio, F. et al. Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation. Ann. Oncol. 25, 404-408 (2014).
    • (2014) Ann. Oncol , vol.25 , pp. 404-408
    • Pietrantonio, F.1
  • 39
    • 84921946952 scopus 로고    scopus 로고
    • RAS testing of colorectal carcinoma-a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group
    • Wong, N. A. et al. RAS testing of colorectal carcinoma-a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group. J. Clin. Pathol. 67, 751-757 (2014).
    • (2014) J. Clin. Pathol , vol.67 , pp. 751-757
    • Wong, N.A.1
  • 40
    • 0036370361 scopus 로고    scopus 로고
    • Generation of HIV-1 derived lentiviral vectors
    • Follenzi, A. & Naldini, L. Generation of HIV-1 derived lentiviral vectors. Methods Enzymol. 346, 454-465 (2002).
    • (2002) Methods Enzymol , vol.346 , pp. 454-465
    • Follenzi, A.1    Naldini, L.2
  • 41
    • 0021910637 scopus 로고
    • A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer
    • Whitehead, R. H., Macrae, F. A., St Sohn, D. J. & Ma, J. A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer. J. Natl Cancer Inst. 74, 759-765 (1985).
    • (1985) J. Natl Cancer Inst , vol.74 , pp. 759-765
    • Whitehead, R.H.1    Macrae, F.A.2    St Sohn, D.J.3    Ma, J.4
  • 42
    • 0036226603 scopus 로고    scopus 로고
    • BLAT-the BLAST-like alignment tool
    • Kent, W. J. BLAT-the BLAST-like alignment tool. Genome Res. 12, 656-664 (2002).
    • (2002) Genome Res , vol.12 , pp. 656-664
    • Kent, W.J.1
  • 44
    • 77949587649 scopus 로고    scopus 로고
    • Fast and accurate long-read alignment with Burrows-Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589-595 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 589-595
    • Li, H.1    Durbin, R.2
  • 45
    • 68549104404 scopus 로고    scopus 로고
    • The Sequence Alignment/Map format and SAMtools
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.