Molecular landscape of acquired resistance to targeted therapy combinations in BRAF-mutant colorectal cancer

Cancer Research

Volumn 76, Issue 15, 2016, Pages 4504-4515

  Oddo, Daniele ^a,b   Sennott, Erin M ^c   Barault, Ludovic ^a,b   Valtorta, Emanuele ^d   Arena, Sabrina ^a,b   Cassingena, Andrea ^d   Filiciotto, Genny ^a,b   Marzolla, Giulia ^a,b   Elez, Elena ^e   Van Geel, Robin M J M ^f   Bartolini, Alice ^b   Crisafulli, Giovanni ^b   Boscaro, Valentina ^g   Godfrey, Jason T ^c   Buscarino, Michela ^b   Cancelliere, Carlotta ^b   Linnebacher, Michael ^h   Corti, Giorgio ^b   Truini, Mauro ^d   Siravegna, Giulia ^a,b,i   Grasselli, Julieta ^e   Gallicchio, Margherita ^g   Bernards, René ^f   Schellens, Jan H M ^f   Tabernero, Josep ^e   Engelman, Jeffrey A ^c,j   Sartore Bianchi, Andrea ^d   Bardelli, Alberto ^a,b   Siena, Salvatore ^d,k   Corcoran, Ryan B ^c,j   Di Nicolantonio, Federica ^a,b   more..

^a UNIVERSITY OF TURIN   (Italy)

^b CANDIOLO CANCER INSTITUTE   (Italy)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^d OSPEDALE NIGUARDA CA GRANDA   (Italy)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f NETHERLANDS CANCER INSTITUTE   (Netherlands)

^g UNIVERSITY OF TURIN   (Italy)

^h UNIVERSITY OF ROSTOCK   (Germany)

ⁱ FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^j HARVARD MEDICAL SCHOOL   (United States)

^k UNIVERSITY OF MILAN   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPELISIB; B RAF KINASE; B RAF KINASE INHIBITOR; BINIMETINIB; CELL DNA; CETUXIMAB; DABRAFENIB; DNA; ENCORAFENIB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GENOMIC DNA; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; SELUMETINIB; TRAMETINIB; VEMURAFENIB;

ARTICLE; BRAF GENE; CANCER COMBINATION CHEMOTHERAPY; CANCER RECURRENCE; CANCER RESISTANCE; CASE REPORT; CELL VIABILITY; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME PHOSPHORYLATION; ENZYME REACTIVATION; ENZYME REPRESSION; GENE AMPLIFICATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; GENOTYPE; HUMAN; INTRACELLULAR SIGNALING; METASTATIC COLORECTAL CANCER; MOLECULARLY TARGETED THERAPY; MONOTHERAPY; MUTATIONAL ANALYSIS; ONCOGENE; ONCOGENE K RAS; PRIORITY JOURNAL; COLORECTAL TUMOR; DRUG RESISTANCE; GENE DOSAGE; GENETICS; PATHOLOGY; SIGNAL TRANSDUCTION;

COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; GENE DOSAGE; HUMANS; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION;

EID: 84982684991     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-16-0396     Document Type: Article

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