Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 50, 2016, Pages 14283-14288

  Han, Jeonghun ^a   Jun, Yukyung ^b   Kim, So Hyun ^c   Hoang, Hong Hoa ^a   Jung, Yeonjoo ^b   Kim, Suyeon ^b   Kim, Jaesang ^b   Austin, Robert H ^d   Lee, Sanghyuk ^b   Park, Sungsu ^a  

^a Sungkyunkwan University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Brain Science Institute   (South Korea)

^d PRINCETON UNIVERSITY   (United States)

Author keywords

Cancer; Doxorubicin; Evolution; Microhabitats; Resistance

Indexed keywords

AKR PROTEIN; AKR1C1 PROTEIN; AKR1C2 PROTEIN; AKR1C3 PROTEIN; ALDO KETO REDUCSHORT ENZYME; CARBOHYDRATE DERIVATIVE; CARD6 PROTEIN; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; DOXORUBICINOL; EOTAXIN 2; EPIRUBICIN; FILAMIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MULTIDRUG RESISTANCE PROTEIN 1; NLRP13 PROTEIN; NSD1 PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN; RHODAMINE 123; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ALDO KETO REDUCTASE; ANTINEOPLASTIC ANTIBIOTIC; FILAMIN;

CANCER RESISTANCE; CANCER STAGING; CELL POPULATION; COMPUTER MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ECOLOGY; ENZYME ACTIVITY; EXOME; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENE ONTOLOGY; GENETIC ANALYSIS; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; METAPOPULATION; MICROFLUIDICS; NUTRIENT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; WHOLE EXOME SEQUENCING; BRAIN TUMOR; DIRECTED MOLECULAR EVOLUTION; DRUG RESISTANCE; GENETICS; GLIOBLASTOMA; LAB ON A CHIP; METABOLISM; MICROFLUIDIC ANALYSIS; MUTATION; PROCEDURES; TUMOR CELL LINE;

ALDO-KETO REDUCTASES; ANTIBIOTICS, ANTINEOPLASTIC; BRAIN NEOPLASMS; CELL LINE, TUMOR; DIRECTED MOLECULAR EVOLUTION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FILAMINS; GLIOBLASTOMA; HUMANS; LAB-ON-A-CHIP DEVICES; MICROFLUIDIC ANALYTICAL TECHNIQUES; MUTATION; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 85005987202     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1614898113     Document Type: Article

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