Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Heibein, Allan D ^a   Guo, Baoqing ^b   Sprowl, Jason A ^a   MacLean, David A ^a,c   Parissenti, Amadeo M ^a,b,c,d  

^a LAURENTIAN UNIVERSITY   (Canada)

^b SUDBURY REGIONAL HOSPITAL   (Canada)

^c NORTHERN ONTARIO SCHOOL OF MEDICINE   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Aldo keto reductases; Cytotoxicity; DNA binding; Doxorubicin; Drug localization; Gene profiling; Lysosome; Pharmacokinetics; PharmGKB; Resistance

Indexed keywords

ALDO KETO REDUCTASE; DOXORUBICIN; DOXORUBICINOL; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG SENSITIVITY; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROXYLATION; LYSOSOME; NUCLEOTIDE SEQUENCE; ONCOGENE; PHARMACODYNAMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

20-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; ALDEHYDE REDUCTASE; BREAST NEOPLASMS; CELL NUCLEUS; CHOLIC ACIDS; CYCLOSPORINE; DNA, NEOPLASM; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION PROFILING; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; INTRACELLULAR SPACE; MCF-7 CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 84865556456     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-381     Document Type: Article

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