메뉴 건너뛰기




Volumn 57, Issue 1, 2017, Pages 207-214

Addressing the unmet need of life-threatening anemia with hemoglobin-based oxygen carriers

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HEMOGLOBIN BASED OXYGEN CARRIER; PLASMA SUBSTITUTE; POLYMERIZED HEMOGLOBIN; UNCLASSIFIED DRUG; OXYGEN;

EID: 85003936018     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/trf.13923     Document Type: Note
Times cited : (41)

References (54)
  • 1
    • 0032554096 scopus 로고    scopus 로고
    • Human cardiovascular and metabolic response to acute, severe isovolemic anemia
    • Weiskopf RB, Viele MK, Feiner J, et al. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA 1998;279:217-21.
    • (1998) JAMA , vol.279 , pp. 217-221
    • Weiskopf, R.B.1    Viele, M.K.2    Feiner, J.3
  • 2
    • 17044413675 scopus 로고    scopus 로고
    • Acute isovolemic anemia impairs central processing as determined by P300 latency
    • Weiskopf RB, Toy P, Hopf HW, et al. Acute isovolemic anemia impairs central processing as determined by P300 latency. Clin Neurophysiol 2005;116:1028-32.
    • (2005) Clin Neurophysiol , vol.116 , pp. 1028-1032
    • Weiskopf, R.B.1    Toy, P.2    Hopf, H.W.3
  • 3
    • 85010569118 scopus 로고    scopus 로고
    • In, Aminoff MJ, editor. Electrodiagnosis in clinical neurology,, 4th ed., San Francisco Churchill Livingstone, p
    • Goodin DS. Event-related potentials. In: Aminoff MJ, editor. Electrodiagnosis in clinical neurology, 4th ed. San Francisco: Churchill Livingstone; 1999. p. 569-85.
    • (1999) Event-related potentials , pp. 569-585
    • Goodin, D.S.1
  • 4
    • 0023036990 scopus 로고
    • Electrophysiological differences between subtypes of dementia
    • Goodin DS, Aminoff MJ. Electrophysiological differences between subtypes of dementia. Brain 1986;109:1103-13.
    • (1986) Brain , vol.109 , pp. 1103-1113
    • Goodin, D.S.1    Aminoff, M.J.2
  • 5
    • 0023102437 scopus 로고
    • Electrophysiological differences between demented and nondemented patients with Parkinson's disease
    • Goodin DS, Aminoff MJ. Electrophysiological differences between demented and nondemented patients with Parkinson's disease. Ann Neurol 1987;21:90-4.
    • (1987) Ann Neurol , vol.21 , pp. 90-94
    • Goodin, D.S.1    Aminoff, M.J.2
  • 6
    • 0036345467 scopus 로고    scopus 로고
    • P300 and clinical patients
    • Polich J. P300 and clinical patients. Clin Electroenceph 2002;33:vi.
    • (2002) Clin Electroenceph , vol.33 , pp. vi
    • Polich, J.1
  • 7
    • 0033801879 scopus 로고    scopus 로고
    • P300 as a clinical assay: rationale, evaluation, and findings
    • Polich J, Herbst KL. P300 as a clinical assay: rationale, evaluation, and findings. Int J Psychophysiol 2000;38:3-19.
    • (2000) Int J Psychophysiol , vol.38 , pp. 3-19
    • Polich, J.1    Herbst, K.L.2
  • 8
    • 0034123632 scopus 로고    scopus 로고
    • Acute severe isovolemic anemia impairs cognitive function and memory in humans
    • Weiskopf RB, Kramer JH, Viele M, et al. Acute severe isovolemic anemia impairs cognitive function and memory in humans. Anesthesiology 2000;92:1646-52.
    • (2000) Anesthesiology , vol.92 , pp. 1646-1652
    • Weiskopf, R.B.1    Kramer, J.H.2    Viele, M.3
  • 9
    • 0036201396 scopus 로고    scopus 로고
    • Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia
    • Weiskopf RB, Feiner J, Hopf HW, et al. Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia. Anesthesiology 2002;96:871-7.
    • (2002) Anesthesiology , vol.96 , pp. 871-877
    • Weiskopf, R.B.1    Feiner, J.2    Hopf, H.W.3
  • 10
    • 84885865525 scopus 로고    scopus 로고
    • Balancing potential risks and benefits of hemoglobin-based oxygen carriers
    • Weiskopf RB, Silverman TA. Balancing potential risks and benefits of hemoglobin-based oxygen carriers. Transfusion 2013;53:2327-33.
    • (2013) Transfusion , vol.53 , pp. 2327-2333
    • Weiskopf, R.B.1    Silverman, T.A.2
  • 11
    • 84962189546 scopus 로고    scopus 로고
    • Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis
    • Docherty AB, O'Donnell R, Brunskill S, et al. Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ 2016;352:i1351.
    • (2016) BMJ , vol.352 , pp. i1351
    • Docherty, A.B.1    O'Donnell, R.2    Brunskill, S.3
  • 12
    • 84926370902 scopus 로고    scopus 로고
    • Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis
    • Holst LB, Petersen MW, Haase N, et al. Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis. BMJ 2015;350:h1354.
    • (2015) BMJ , vol.350 , pp. h1354
    • Holst, L.B.1    Petersen, M.W.2    Haase, N.3
  • 13
    • 84943260109 scopus 로고    scopus 로고
    • Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials
    • Fominskiy E, Putzu A, Monaco F, et al. Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials. Br J Anaesth 2015;115:511-9.
    • (2015) Br J Anaesth , vol.115 , pp. 511-519
    • Fominskiy, E.1    Putzu, A.2    Monaco, F.3
  • 14
    • 84966714407 scopus 로고    scopus 로고
    • Restrictive versus liberal transfusion strategy in the perioperative and acute care settings: a context-specific systematic review and meta-analysis of randomized controlled trials
    • Hovaguimian F, Myles PS. Restrictive versus liberal transfusion strategy in the perioperative and acute care settings: a context-specific systematic review and meta-analysis of randomized controlled trials. Anesthesiology 2016;125:46-61.
    • (2016) Anesthesiology , vol.125 , pp. 46-61
    • Hovaguimian, F.1    Myles, P.S.2
  • 15
    • 84855398591 scopus 로고    scopus 로고
    • Liberal or restrictive transfusion in high-risk patients after hip surgery
    • Carson JL, Terrin ML, Noveck H, et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011;365:2453-62.
    • (2011) N Engl J Med , vol.365 , pp. 2453-2462
    • Carson, J.L.1    Terrin, M.L.2    Noveck, H.3
  • 16
    • 84871730245 scopus 로고    scopus 로고
    • Transfusion strategies for acute upper gastrointestinal bleeding
    • Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013;368:11-21.
    • (2013) N Engl J Med , vol.368 , pp. 11-21
    • Villanueva, C.1    Colomo, A.2    Bosch, A.3
  • 17
    • 0036654548 scopus 로고    scopus 로고
    • Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion
    • Carson JL, Noveck H, Berlin JA, et al. Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion. Transfusion 2002;42:812-8.
    • (2002) Transfusion , vol.42 , pp. 812-818
    • Carson, J.L.1    Noveck, H.2    Berlin, J.A.3
  • 18
    • 84908472667 scopus 로고    scopus 로고
    • An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion (CME)
    • Shander A, Javidroozi M, Naqvi S, et al. An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion (CME). Transfusion 2014;54:2688-95.
    • (2014) Transfusion , vol.54 , pp. 2688-2695
    • Shander, A.1    Javidroozi, M.2    Naqvi, S.3
  • 19
    • 84862338600 scopus 로고    scopus 로고
    • Clinical benefits and cost-effectiveness of allogeneic red-blood-cell transfusion in severe symptomatic anaemia
    • Beliaev AM, Marshall RJ, Gordon M, et al. Clinical benefits and cost-effectiveness of allogeneic red-blood-cell transfusion in severe symptomatic anaemia. Vox Sang 2012;103:18-24.
    • (2012) Vox Sang , vol.103 , pp. 18-24
    • Beliaev, A.M.1    Marshall, R.J.2    Gordon, M.3
  • 20
    • 57149093993 scopus 로고    scopus 로고
    • HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery
    • Jahr JS, Mackenzie C, Pearce LB, et al. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma 2008;64:1484-97.
    • (2008) J Trauma , vol.64 , pp. 1484-1497
    • Jahr, J.S.1    Mackenzie, C.2    Pearce, L.B.3
  • 21
    • 77949295669 scopus 로고    scopus 로고
    • When blood is not an option: factors affecting survival after use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia
    • Mackenzie CF, Moon-Massat PF, Shander A, et al. When blood is not an option: factors affecting survival after use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia. Anesth Analg 2010;110:685-93.
    • (2010) Anesth Analg , vol.110 , pp. 685-693
    • Mackenzie, C.F.1    Moon-Massat, P.F.2    Shander, A.3
  • 22
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 23
    • 84965234664 scopus 로고
    • A Lecture on the symptoms, causes, and prevention of anoxaemia (insufficient supply of oxygen to the tissues), and the value of oxygen in its treatment
    • Haldane JS. A Lecture on the symptoms, causes, and prevention of anoxaemia (insufficient supply of oxygen to the tissues), and the value of oxygen in its treatment. Br Med J 1919;2:65-71.
    • (1919) Br Med J , vol.2 , pp. 65-71
    • Haldane, J.S.1
  • 25
    • 0013802060 scopus 로고
    • Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia
    • Cain SM. Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia. Am J Physiol 1965;209:604-10.
    • (1965) Am J Physiol , vol.209 , pp. 604-610
    • Cain, S.M.1
  • 26
    • 0027218143 scopus 로고
    • Limit to cardiac compensation during acute isovolemic hemodilution: influence of coronary stenosis
    • Levy P, Kim S, Eckel P, et al. Limit to cardiac compensation during acute isovolemic hemodilution: influence of coronary stenosis. Am J Physiol 1993;265:H340-9.
    • (1993) Am J Physiol , vol.265 , pp. H340-H349
    • Levy, P.1    Kim, S.2    Eckel, P.3
  • 27
    • 0343360868 scopus 로고    scopus 로고
    • A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group
    • Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999;340:409-17.
    • (1999) N Engl J Med , vol.340 , pp. 409-417
    • Hébert, P.C.1    Wells, G.2    Blajchman, M.A.3
  • 28
    • 0033960741 scopus 로고    scopus 로고
    • Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(−1) x min(−1)
    • Lieberman JA, Weiskopf RB, Kelley SD, et al. Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(−1) x min(−1). Anesthesiology 2000;92:407-13.
    • (2000) Anesthesiology , vol.92 , pp. 407-413
    • Lieberman, J.A.1    Weiskopf, R.B.2    Kelley, S.D.3
  • 29
    • 67649908274 scopus 로고    scopus 로고
    • Time course and etiology of death in patients with severe anemia
    • Tobian AA, Ness PM, Noveck H, et al. Time course and etiology of death in patients with severe anemia. Transfusion 2009;49:1395-9.
    • (2009) Transfusion , vol.49 , pp. 1395-1399
    • Tobian, A.A.1    Ness, P.M.2    Noveck, H.3
  • 30
    • 25144436375 scopus 로고    scopus 로고
    • Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery
    • Karkouti K, Djaiani G, Borger MA, et al. Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery. Ann Thorac Surg 2005;80:1381-7.
    • (2005) Ann Thorac Surg , vol.80 , pp. 1381-1387
    • Karkouti, K.1    Djaiani, G.2    Borger, M.A.3
  • 31
    • 0344222164 scopus 로고    scopus 로고
    • Prophylactic atenolol reduces postoperative myocardial ischemia
    • Wallace A, Layug B, Tateo I, et al. Prophylactic atenolol reduces postoperative myocardial ischemia. Anesthesiology 1998;88:7-17.
    • (1998) Anesthesiology , vol.88 , pp. 7-17
    • Wallace, A.1    Layug, B.2    Tateo, I.3
  • 32
    • 0025730035 scopus 로고
    • Perioperative myocardial ischemia in patients undergoing noncardiac surgery-II: incidence and severity during the 1st week after surgery. The Study of Perioperative Ischemia (SPI) Research Group
    • Mangano DT, Wong MG, London MJ, et al. Perioperative myocardial ischemia in patients undergoing noncardiac surgery-II: incidence and severity during the 1st week after surgery. The Study of Perioperative Ischemia (SPI) Research Group. J Am Coll Cardiol 1991;17:851-7.
    • (1991) J Am Coll Cardiol , vol.17 , pp. 851-857
    • Mangano, D.T.1    Wong, M.G.2    London, M.J.3
  • 33
    • 0032033379 scopus 로고    scopus 로고
    • Evaluation of the oxygen delivery ability of PEG-hemoglobin in Sprague-Dawley rats during hemodilution
    • Conover C, Linberg R, Lejeune L, et al. Evaluation of the oxygen delivery ability of PEG-hemoglobin in Sprague-Dawley rats during hemodilution. Artif Cells Blood Substit Immobil Biotechnol 1998;26:199-212.
    • (1998) Artif Cells Blood Substit Immobil Biotechnol , vol.26 , pp. 199-212
    • Conover, C.1    Linberg, R.2    Lejeune, L.3
  • 34
    • 34250695985 scopus 로고    scopus 로고
    • Low-volume resuscitation cocktail extends survival after severe hemorrhagic shock
    • Reynolds PS, Barbee RW, Skaflen MD, et al. Low-volume resuscitation cocktail extends survival after severe hemorrhagic shock. Shock 2007;28:45-52.
    • (2007) Shock , vol.28 , pp. 45-52
    • Reynolds, P.S.1    Barbee, R.W.2    Skaflen, M.D.3
  • 35
    • 67349085334 scopus 로고    scopus 로고
    • Hemospan improves outcome in a model of perioperative hemodilution and blood loss in the rat: comparison with hydroxyethyl starch
    • Young MA, Lohman J, Malavalli A, et al. Hemospan improves outcome in a model of perioperative hemodilution and blood loss in the rat: comparison with hydroxyethyl starch. J Cardiothorac Vasc Anesth 2009;23:339-47.
    • (2009) J Cardiothorac Vasc Anesth , vol.23 , pp. 339-347
    • Young, M.A.1    Lohman, J.2    Malavalli, A.3
  • 36
    • 23844531886 scopus 로고    scopus 로고
    • MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine
    • Young MA, Riddez L, Kjellstrom BT, et al. MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Crit Care Med 2005;33:1794-804.
    • (2005) Crit Care Med , vol.33 , pp. 1794-1804
    • Young, M.A.1    Riddez, L.2    Kjellstrom, B.T.3
  • 37
    • 57749197384 scopus 로고    scopus 로고
    • Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial
    • Moore EE, Moore FA, Fabian TC, et al. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial. J Am Coll Surg 2009;208:1-13.
    • (2009) J Am Coll Surg , vol.208 , pp. 1-13
    • Moore, E.E.1    Moore, F.A.2    Fabian, T.C.3
  • 38
    • 0033579126 scopus 로고    scopus 로고
    • Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial
    • Sloan EP, Koenigsberg M, Gens D, et al. Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. JAMA 1999;282:1857-64.
    • (1999) JAMA , vol.282 , pp. 1857-1864
    • Sloan, E.P.1    Koenigsberg, M.2    Gens, D.3
  • 39
    • 77749237150 scopus 로고    scopus 로고
    • Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs
    • Te Lintel Hekkert M, Dube GP, Regar E, et al. Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs. Am J Physiol Heart Circ Physiol 2010;298:H1103-13.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H1103-H1113
    • Te Lintel Hekkert, M.1    Dube, G.P.2    Regar, E.3
  • 40
    • 59249103363 scopus 로고    scopus 로고
    • Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results
    • Meliga E, Vranckx P, Regar E, et al. Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results. EuroIntervention 2008;4:99-107.
    • (2008) EuroIntervention , vol.4 , pp. 99-107
    • Meliga, E.1    Vranckx, P.2    Regar, E.3
  • 41
    • 67649290230 scopus 로고    scopus 로고
    • Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD
    • Serruys PW, Vranckx P, Slagboom T, et al. Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD. EuroIntervention 2008;3:600-9.
    • (2008) EuroIntervention , vol.3 , pp. 600-609
    • Serruys, P.W.1    Vranckx, P.2    Slagboom, T.3
  • 42
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LJ, Buga GM, Wood KS, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A 1987;84:9265-9.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3
  • 43
    • 0023518452 scopus 로고
    • Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical
    • Ignarro LJ, Byrns RE, Buga GM, et al. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 1987;61:866-79.
    • (1987) Circ Res , vol.61 , pp. 866-879
    • Ignarro, L.J.1    Byrns, R.E.2    Buga, G.M.3
  • 44
    • 0002732412 scopus 로고
    • The rate of uptake of carbon monoxide and of nitric oxide by normal human erythrocytes and experimentally produced spherocytes
    • Carlsen E, Comroe JH Jr. The rate of uptake of carbon monoxide and of nitric oxide by normal human erythrocytes and experimentally produced spherocytes. J Gen Physiol 1958;42:83-107.
    • (1958) J Gen Physiol , vol.42 , pp. 83-107
    • Carlsen, E.1    Comroe, J.H.2
  • 45
    • 0003098642 scopus 로고
    • The reactions of sheep haemoglobin with nitric acid oxide
    • Gibson QH, Roughton FJ. The reactions of sheep haemoglobin with nitric acid oxide. J Physiol 1955;128:69-70P.
    • (1955) J Physiol , vol.128 , pp. 69-70P
    • Gibson, Q.H.1    Roughton, F.J.2
  • 46
    • 0032545463 scopus 로고    scopus 로고
    • Reduced nitric oxide reactivity of a new recombinant human hemoglobin attenuates gastric dysmotility
    • Hartman JC, Argoudelis G, Doherty D, et al. Reduced nitric oxide reactivity of a new recombinant human hemoglobin attenuates gastric dysmotility. Eur J Pharmacol 1998;363:175-8.
    • (1998) Eur J Pharmacol , vol.363 , pp. 175-178
    • Hartman, J.C.1    Argoudelis, G.2    Doherty, D.3
  • 47
    • 0031856673 scopus 로고    scopus 로고
    • Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin
    • Doherty DH, Doyle MP, Curry SR, et al. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol 1998;16:672-6.
    • (1998) Nat Biotechnol , vol.16 , pp. 672-676
    • Doherty, D.H.1    Doyle, M.P.2    Curry, S.R.3
  • 48
    • 0018940790 scopus 로고
    • Dose responses of cerebral arteries of the dog, rabbit, and man to human hemoglobin in vitro
    • Wellum GR, Irvine TW Jr, Zervas NT. Dose responses of cerebral arteries of the dog, rabbit, and man to human hemoglobin in vitro. J Neurosurg 1980;53:486-90.
    • (1980) J Neurosurg , vol.53 , pp. 486-490
    • Wellum, G.R.1    Irvine, T.W.2    Zervas, N.T.3
  • 49
    • 0030944331 scopus 로고    scopus 로고
    • Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics
    • Viele M, Weiskopf R, Fisher D. Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics. Anesthesiology 1997;86:848-58.
    • (1997) Anesthesiology , vol.86 , pp. 848-858
    • Viele, M.1    Weiskopf, R.2    Fisher, D.3
  • 50
    • 70350441470 scopus 로고    scopus 로고
    • Planning Committee and the Speakers. Hemoglobin-based oxygen carriers: current status and future directions
    • Silverman TA, Weiskopf RB; Planning Committee and the Speakers. Hemoglobin-based oxygen carriers: current status and future directions. Anesthesiology 2009;111:946-63.
    • (2009) Anesthesiology , vol.111 , pp. 946-963
    • Silverman, T.A.1    Weiskopf, R.B.2
  • 51
    • 70449127973 scopus 로고    scopus 로고
    • Hemoglobin based oxygen carriers: current status and future directions
    • Silverman TA, Weiskopf RB. Hemoglobin based oxygen carriers: current status and future directions. Transfusion 2009;49:2495-515.
    • (2009) Transfusion , vol.49 , pp. 2495-2515
    • Silverman, T.A.1    Weiskopf, R.B.2
  • 52
    • 0028270996 scopus 로고
    • What can we learn about the need for transfusion from patients who refuse blood? The experience with Jehovah's Witnesses
    • Viele MK, Weiskopf RB. What can we learn about the need for transfusion from patients who refuse blood? The experience with Jehovah's Witnesses. Transfusion 1994;34:396-401.
    • (1994) Transfusion , vol.34 , pp. 396-401
    • Viele, M.K.1    Weiskopf, R.B.2
  • 53
    • 84870064759 scopus 로고    scopus 로고
    • Being ‘underpowered’ does not make a study unethical
    • author reply 4140-1
    • Bacchetti P, McCulloch C, Segal MR. Being ‘underpowered’ does not make a study unethical. Stat Med 2012;31:4138-9; author reply 4140-1.
    • (2012) Stat Med , vol.31 , pp. 4138-4139
    • Bacchetti, P.1    McCulloch, C.2    Segal, M.R.3
  • 54
    • 0037125417 scopus 로고    scopus 로고
    • The continuing unethical conduct of underpowered clinical trials
    • Halpern SD, Karlawish JH, Berlin JA. The continuing unethical conduct of underpowered clinical trials. JAMA 2002;288:358-62.
    • (2002) JAMA , vol.288 , pp. 358-362
    • Halpern, S.D.1    Karlawish, J.H.2    Berlin, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.