Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin

Nature Biotechnology

Volumn 16, Issue 7, 1998, Pages 672-676

  Doherty, Daniel H ^a   Doyle, Michael P ^a   Curry, Shawn R ^a   Vali, Rita J ^a   Fattor, Timothy J ^a   Olson, John S ^b   Lemon, Douglas D ^a  

^a BAXTER HEALTHCARE CORPORATION   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

Blood substitute; Protein engineering

Indexed keywords

HEMOGLOBIN; NITRIC OXIDE;

ARTICLE; AUTOOXIDATION; BINDING AFFINITY; BLOOD PRESSURE REGULATION; CELL FREE SYSTEM; GENETIC ENGINEERING; HYPERTENSION; NONHUMAN; OXYGEN TRANSPORT; POLYMERIZATION; PRIORITY JOURNAL; REACTION ANALYSIS; VASCULAR SMOOTH MUSCLE;

ANIMALS; BLOOD PRESSURE; FREE RADICAL SCAVENGERS; HEMOGLOBINS; HYPERTENSION; MALE; NITRIC OXIDE; OXYGEN CONSUMPTION; OXYHEMOGLOBINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

OXY;

EID: 0031856673     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0798-672     Document Type: Article

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