Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials

British Journal of Anaesthesia

Volumn 115, Issue 4, 2015, Pages 511-519

  Fominskiy, E ^a,b   Putzu, A ^a   Monaco, F ^a   Scandroglio, A M ^a   Karaskov, A ^b   Galas, F R B G ^c   Hajjar, L A ^c   Zangrillo, A ^a,d   Landoni, G ^a,d  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b MESHALKIN NATIONAL MEDICAL RESEARCH CENTER   (Russian Federation)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

anesthesia; blood transfusion; critical illness; mortality; perioperative care

Indexed keywords

HEMOGLOBIN;

ARTICLE; BLOOD TRANSFUSION; CAUSE OF DEATH; CRITICALLY ILL PATIENT; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; LIBERAL BLOOD TRANSFUSION; META ANALYSIS; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESTRICTIVE BLOOD TRANSFUSION; SURGICAL MORTALITY; SURGICAL PATIENT; SURVIVAL; SYSTEMATIC REVIEW; CRITICAL ILLNESS; INTENSIVE CARE; MORTALITY; PROCEDURES; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

BLOOD TRANSFUSION; CRITICAL CARE; CRITICAL ILLNESS; HUMANS; PERIOPERATIVE CARE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84943260109     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aev317     Document Type: Review

References (47)

1. http://www.hcup-us.ahrq.gov/reports/statbriefs/sb165.jsp (accessed 15 March 2015)
2. Whitaker BI, Hinkins S. The 2011 national blood collection and utilization survey. http:// http://www.aabb.org (accessed 15 March 2015)
3. Takei T, Amin NA, Schmid G, Dhingra-Kumar N, Rugg D. Progress in global blood safety for HIV. J Acquir Immune Defic Syndr 2009; 52: S127-31
4. Marik PE, Corwin HL. Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature. Crit Care Med 2008; 36: 2667.74
5. Hopewell S, Omar O, Hyde C, Yu LM, Doree C, Murphy MF. A systematic review of the effect of red blood cell transfusion on mortality: evidence fromlarge-scale observational studies published between 2006 and 2010. Br Med J Open 2013; 3: e002154
6. Carson JL, Carless PA, Hebert PC. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2012; 18: CD002042
7. Curley GF, Shehata N, Mazer CD, Hare GM, Friedrich JO. Transfusion triggers for guiding RBC transfusion for cardiovascular surgery: A systematic review and meta-analysis. Crit Care Med 2014; 42: 2611-24
8. Holst LB, Petersen MW, Haase N, Perner A, Wetterslev J. Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis. Br Med J 2015; 350: h1354
9. Salpeter SR, Buckley JS, Chatterjee S. Impact of more restrictive blood transfusion strategies on clinical outcomes: A metaanalysis and systematic review. Am J Med 2014; 127: 124-31
10. Murphy GJ, Pike K, Rogers CA, et al. Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 2015; 372: 997-1008
11. de Almeida JP, Vincent JL, Galas FR, et al. Transfusion requirements in surgical oncology patients: A prospective, randomized controlled trial. Anesthesiology 2015; 122: 29-38
12. Gregersen M, Borris LC, Damsgaard EM. Postoperative blood transfusion strategy in frail, anemic elderly patients with hip fracture. Acta Orthop 2015; 86: 363-72
13. Bergamin F, Almeida J, Park C, et al. Transfusion requirements in septic shock patients: A randomized controlled trial. Critical Care 2014; 18: P112
14. Blair SD, Janvrin SB, McCollum CN, Greenhalgh RM. Effect of early blood transfusion on gastrointestinal haemorrhage. Br J Surg 1986; 73: 783-5
15. Bracey AW, Radovancevic R, Riggs SA, et al. Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. Transfusion 1999; 39: 1070-7
16. Bush RL, Pevec WC, Holcroft JW. A prospective, randomized trial limiting perioperative red blood cell transfusions in vascular patients. Am J Surg 1997; 174: 143-8
17. Carson JL, Terrin ML, Barton FB, et al. A pilot randomized trial comparing symptomatic vs.: hemoglobin-level-driven red blood cell transfusions following hip fracture. Transfusion 1998; 38: 522-9
18. Carson JL, Terrin ML, Noveck H, et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011; 365: 2453-62
19. Carson JL, Brooks MM, Abbott JD, et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 2013; 165: 964-71
20. Cooper HA, Rao SV, Greenberg MD, et al. Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). Am J Cardiol 2011; 108: 1108-11
21. Foss NB, KristensenMT, Jensen PS, PalmH, KrasheninnikoffM, Kehlet H. The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. Transfusion 2009; 49: 227-34
22. Grover M, Talwalkar S, Casbard A, et al. Silent myocardial ischaemia and haemoglobin concentration: A randomized controlled trial of transfusion strategy in lower limb arthroplasty. Vox Sang 2006; 90: 105-12
23. Hajjar LA, Vincent JL, Galas FR, et al. Transfusion requirements after cardiac surgery: The TRACS randomized controlled trial. JAMA 2010; 304: 1559-67
24. Hebert PC,Wells G, Marshall J, et al. Transfusion requirements in critical care. A pilot study. Canadian Critical Care Trials Group. JAMA 1995; 273: 1439-44
25. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340: 409-17
26. Holst LB, Haase N, Wetterslev J, et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 2014; 371: 1381-91
27. Junio JAE, Gamponia R. Post-operative outcomes of CABG patients given blood transfusion based on society of thoracic surgeons guidelines on blood transfusion. Phil Heart Center J 2012; 16: 47-54
28. Nielsen K, Dahl B, Johansson PI, Henneberg SW, Rasmussen LS. Intraoperative transfusion threshold and tissue oxygenation: A randomised trial. Transfus Med 2012; 22: 418-25
29. Nielsen K, Johansson PI, Dahl B, et al. Perioperative transfusion threshold and ambulation after hip revision surgery.a randomized trial. BMC Anesthesiol 2014; 14: 89
30. Parker MJ. Randomised trial of blood transfusion versus a restrictive transfusion policy after hip fracture surgery. Injury 2013; 44: 1916-8
31. Prick BW, Jansen AJ, Steegers EA, et al. Transfusion policy after severe postpartum haemorrhage: A randomised noninferiority trial. BJOG 2014; 121: 1005-14
32. Robertson CS, Hannay HJ, Yamal JM, et al. Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: A randomized clinical trial. JAMA 2014; 312: 36-47
33. Shehata N, Burns LA, Nathan H, et al. A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. Transfusion 2012; 52: 91-9
34. So-Osman C, Nelissen R, Te Slaa R, Coene L, Brand R, Brand A. A randomized comparison of transfusion triggers in elective orthopaedic surgery using leucocyte-depleted red blood cells. Vox Sang 2010; 98: 56-64
35. Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl JMed 2013; 368: 11-21
36. Walsh TS, Boyd JA, Watson D, et al. Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: A randomized pilot trial. Crit Care Med 2013; 41: 2354-63
37. Society of Thoracic Surgeons Blood Conservation Guideline Task ForceFerraris VA, Brown JR, Despotis GJ, et al. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg 2011; 91: 944-82
38. Carson JL, Grossman BJ, Kleinman S, et al. Red blood cell transfusion: A clinical practice guideline from the AABB. Ann Intern Med 2012; 157: 49-58
39. Fleisher LA, Fleischmann KE, Auerbach AD, et al. 2014 ACC/ AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol 2014; 64: e77-137
40. [No authors listed]. Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology 2015; 122: 241-75
41. Chatterjee S,Wetterslev J, SharmaA, Lichstein E,MukherjeeD. Association of blood transfusion with increased mortality in myocardial infarction: ameta-analysis and diversity-adjusted study sequential analysis. JAMA Intern Med 2013; 173: 132-9
42. Whitlock EL, Kim H, Auerbach AD. Harms associated with single unit perioperative transfusion: retrospective population based analysis. Br Med J 2015; 350: h3037
43. Spinelli E, Bartlett RH. Anaemia and Transfusion in Critical Care: Physiology and Management. J Intensive Care Med 2015; [Epub ahead of print]
44. Shander A. Anaemia in the critically ill. Crit Care Clin 2004; 20: 159-78
45. Athar MK, Puri N, Gerber DR. Anaemia and blood transfusions in critically ill patients. J Blood Transfus 2012; 2012: 629204
46. Greco T, Zangrillo A, Biondi-Zoccai G, Landoni G. Meta-analysis: pitfalls and hints. Heart Lung Vessel 2013; 5: 219-25
47. Landoni G, Rodseth RN, Santini F, et al. Randomized evidence for reduction of perioperative mortality. J Cardiothorac Vasc Anesth 2012; 26: 764-72