MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine

Critical Care Medicine

Volumn 33, Issue 8, 2005, Pages 1794-1804

  Young, Mark A ^a   Riddez, Louis ^c   Kjellström, Bengt Thomas ^d,e   Bursell, Jenny ^e   Winslow, Ford ^a   Lohman, Jeffrey ^a   Winslow, Robert M ^a,b,f  

^a Sangart   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d STOCKHOLM SÖDER HOSPITAL   (Sweden)

^e SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^f SANGART INC   (United States)

Author keywords

Blood substitutes; Hemoglobin; MP4; PEG; Shock; Uncontrolled hemorrhage

Indexed keywords

ELECTROLYTE; HEMOGLOBIN; HETASTARCH; LACTIC ACID; MALEIMIDE POLYETHYLENE GLYCOL MODIFIED HEMOGLOBIN; RINGER ACETATE; STROMA FREE HEMOGLOBIN; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ALKALOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA PERFORATION; AORTA PRESSURE; AORTA SURGERY; ARTERIAL GAS; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BODY WEIGHT; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; FEMALE; HEART OUTPUT; HEMATOCRIT; HEMODYNAMIC MONITORING; HEMODYNAMICS; HEMORRHAGIC SHOCK; LUNG ARTERY PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; SWINE; THERMODILUTION; TREATMENT OUTCOME; URINE VOLUME;

EID: 23844531886     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000172648.55309.13     Document Type: Article

References (48)

1. Proctor KG: Blood substitutes and experimental models of trauma. J Trauma 2003; 54:3106-3109
2. Creteur J, Vincent JL: Hemoglobin solutions. Crit Care Med 2003; 31:3698-3707
3. Stowell CP: Hemoglobin-based oxygen carriers. Curr Opin Hematol 2002; 9:537-543
4. Winslow R: Oxygen transport agents: A new approach to red blood cell alternatives. TATM 2004; 5:498-504
5. Reid TJ: Hb-based oxygen carriers: Are we there yet? Transfusion 2003; 43:280-287
6. Hess J, Macdonald V, Brinkley W: Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 1993; 74:1769-1778
7. Malcolm D, Hamilton IJ, Schultz S, et al: Characterization of the hemodynamic response to intravenous diaspirin crosslinked hemoglobin solution in rats. Artif Cells Blood Substit Immobil Biotechnol 1994; 22:91-107
8. Przybelski R, Malcolm D, Burris D, et al: Cross-linked hemoglobin solution as a resuscitative fluid after hemorrhage in the rat. J Lab Clin Med 1991; 117:143-151
9. Kasper SM, Grune F, Walter M, et al: The effects of increased doses of bovine hemoglobin on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg 1998; 87:284-291
10. Przybelski RJ, Daily EK, Kisicki JC, et al: Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution. Crit Care Med 1996; 24:1993-2000
11. Levy J, Goodnough L, Greilich P, et al: Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a randomized, double-blind trial. J Thorac Cardiovasc Surg 2002; 124:35-42
12. Hill SE, Gottschalk LI, Grichnik K: Safety and preliminary efficacy of hemoglobin raffimer for patients undergoing coronary artery bypass surgery. J Cardiothorac Vasc Anesth 2002; 16:695-702
13. Winslow RM: αα-Crosslinked hemoglobin: Was failure predicted by preclinical testing? Vox Sang 2000; 79:1-20
14. Przybelski RJ, Daily EK, Birnbaum ML: The pressor effect of hemoglobin-good or bad? In: Advances in Blood Substitutes. Industrial Opportunities and Medical Challenges. Winslow RM, Vandegriff KD, Intaglietta M (Eds). Boston, Birkhäuser, 1997, pp 71-85
15. Vane LA, Funston J, Kirschner R, et al: Comparison of transfusion with DCHLb or pRBC's for treatment of intraoperative anemia in sheep. J Appl Physiol 2002; 92:343-353
16. McNeil CJ, Smith LD, Jenkins LD, et al: Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. J Trauma 2001; 50:1063-1075
17. Sampson JB, Davis MR, Mueller DL, et al: A comparison of the hemoglobin-based oxygen carrier HBOC-201 to other low-volume resuscitation fluids in a model of controlled hemorrhagic shock. J Trauma 2003; 55:747-754
18. York GB, Eggers JS, Smith DL, et al: Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage. J Trauma 2003; 55:873-885
19. Winslow R: Alternative oxygen therapeutics: Products, status of clinical trials, and future prospects. Curr Hematol Rep 2003; 2:503-510
20. Doherty DH, Doyle MP, Curry SR, et al: Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nature Biotechnology 1998; 16:672-676
21. Matheson B, Kwansa HE, Bucci E, et al: Vascular response to infusions of a nonextravasating hemoglobin polymer. J Appl Physiol 2002; 93:1479-1486
22. McCarthy MR, Vandegriff KD, Winslow RM: The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: Implications for the design of hemoglobin-based oxygen carriers. Biophys Chem 2001; 92:103-117
23. Vandegriff K, Malavalli A, Wooldridge J, et al: MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion 2003; 43:509-516
24. 2 delivery by cell-free hemoglobin: A new basis for oxygen therapeutics. Am J Physiol 2003; 285:H1411-H1419
25. Winslow RM, Gonzales A, Gonzales M, et al: Vascular resistance and the efficacy of red cell substitutes in a rat hemorrhage model. J Appl Physiol 1998; 85:993-1003
26. Drobin D, Kjellstrom B, Malm E, et al: Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4). J Appl Physiol 2004; 96:1843-1853
27. Acharya AS, Manjula BN, Smith P, inventors: Hemoglobin crosslinkers. Albert Einstein College of Medicine of Yeshiva University. US patent 5,585,484), 1-16. 1996
28. Vandegriff KD, Rohlfs RJ, Magde MD, et al: Hemoglobin-oxygen equilibrium curves measured during enzymatic oxygen consumption. Anal Biochem 1998; 256:107-116
29. Dunlap E, Farrell L, Nigro C, et al: Resuscitation with diaspirin crosslinked hemoglobin in a pig model of hemorrhagic shock. Artif Cells Blood Substit Immobil Biotechnol 1995; 23:39-61
30. Katz L, Manning J, McCurdy S, et al: HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury. Resuscitation 2002; 54:77-87
31. Maxwell RA, Gibson JB, Fabian TC, et al: Resuscitation of severe chest trauma with four different hemoglobin-based oxygen-carrying solutions. J Trauma 2000; 49:200-209
32. Gibson JB, Maxwell RA, Schweitzer JB, et al: Resuscitation from severe hemorrhagic shock after traumatic brain injury using saline, shed blood, or a blood substitute. Shock 2002; 17:234-244
33. Winslow RM, Lohman J, Malavalli A, et al: A comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat. J Appl Physiol 2004; 97:1527-15344
34. Schultz S, Hamilton IJ, Malcolm D. Use of base deficit to compare resuscitation with lactated Ringer's solution, Haemaccel, whole blood, and diaspirin cross- linked hemoglobin following hemorrhage in rats. J Trauma 1993; 35:619-625
35. Malhotra AK, Kelly ME, Miller PR, et al: Resuscitation with a novel hemoglobin-based oxygen carrier in a swine model of uncontrolled perioperative hemorrhage. J Trauma 2003; 54:915-924
36. Weil M, von Planta M, Rackow EC. Acute circulatory failure (shock). In: Heart Disease. Braunwald E (Ed). Philadelphia, Saunders, 1988, pp 561-580
37. Wettstein R, Tsai A, Erni D, et al: Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters. Crit Care Med 2003; 31:1824-1830
38. Ragaller MJ, Theilen H, Koch T: Volume replacement in critically ill patients with acute renal failure. J Am Soc Nephrol 2001; 17(12 Suppl):S33-S39
39. Boldt J, Heesen M, Muller M, et al: The effects of albumin versus hydroxyethyl starch solution on cardiorespiratory and circulatory variables in critically ill patients. Anesth Analg 1996; 83:254-261
40. Treib J, Baron JF, Grauer MT, et al: An international view of hydroxyethyl starches. Intensive Care Med 1999; 25:258-268
41. Wiggers CJ: Physiology of Shock. New York, The Commonwealth Fund, 1950.
42. Engoren M, Severyn F, Fenn-Buderer N, et al: Cardiac output, coronary blood flow, and blood gases during open-chest standard and compression-active- decompression cardiopulmonary resuscitation. Resuscitation 2002; 55:309-316
43. Stern S, Kowalenko T, Younger J, et al: Comparison of the effects of bolus vs slow infusion of 7.5% NaCl/6% dextran-70 in a model of near-lethal uncontrolled hemorrhage. Shock 2000; 14:616-622
44. Moore FA, McKinley BA, Moore EE: The next generation in shock resuscitation. Lancet 2004; 363:1988-1996
45. Rizoli SB: Crystalloids and colloids in trauma resuscitation: A brief overview of the current debate. J Trauma 2003; 54:S82-S88
46. Kramer G: Counterintuitive red blood cell substitute-Polyethylene glycol-modified human hemoglobin. Crit Care Med 2003; 31:1882-1883
47. Rohlfs R, Vandegriff K, Winslow R. The reaction of nitric oxide with cell-free hemoglobin based oxygen carriers: Physiological implications. In: Advances in Blood Substitutes. Industrial Opportunities and Medical Challenges. Winslow R, Vandegriff K, Intaglietta M (Eds). Boston, Birkhäuser, 1997, pp 298-327
48. Rohlfs RJ, Bruner E, Chiu A, et al: Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide. J Biol Chem 1998; 273:12128-12134