메뉴 건너뛰기




Volumn 36, Issue 1, 2015, Pages 60-67

Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues

(11)  Llanos, Adana A a,b   Dumitrescu, Ramona G c,d   Brasky, Theodore M e   Liu, Zhenhua f,g   Mason, Joel B f   Marian, Catalin e,h   Makambi, Kepher H i   Spear, Scott L j   Kallakury, Bhaskar V S j   Freudenheim, Jo L k   Shields, Peter G e  


Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; FOLIC ACID; GENOMIC DNA; LIQUID NITROGEN; PROTEIN P16; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; METHIONINE SYNTHASE REDUCTASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MTHFD1 PROTEIN, HUMAN;

EID: 85003054041     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu219     Document Type: Article
Times cited : (15)

References (48)
  • 1
    • 73549104794 scopus 로고    scopus 로고
    • Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids
    • Zhu,W. et al. (2010) Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids. Int. J. Cancer, 126, 474–482.
    • (2010) Int. J. Cancer , vol.126 , pp. 474-482
    • Zhu, W.1
  • 2
    • 68149106154 scopus 로고    scopus 로고
    • Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer
    • Vallian,S. et al. (2009) Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer. J. Cancer Res. Clin. Oncol., 135, 991–996.
    • (2009) J. Cancer Res. Clin. Oncol , vol.135 , pp. 991-996
    • Vallian, S.1
  • 3
    • 80053637383 scopus 로고    scopus 로고
    • Promoter methylation of E-cadherin, p16, and RAR-β(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism
    • Tao,M.H. et al. (2011) Promoter methylation of E-cadherin, p16, and RAR-β(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism. Nutr. Cancer, 63, 1143–1150.
    • (2011) Nutr. Cancer , vol.63 , pp. 1143-1150
    • Tao, M.H.1
  • 4
    • 77955132259 scopus 로고    scopus 로고
    • Familial and racial determinants of tumour suppressor genes promoter hypermethylation in breast tissues from healthy women
    • Dumitrescu,R.G. et al. (2010) Familial and racial determinants of tumour suppressor genes promoter hypermethylation in breast tissues from healthy women. J. Cell. Mol. Med., 14, 1468–1475.
    • (2010) J. Cell. Mol. Med , vol.14 , pp. 1468-1475
    • Dumitrescu, R.G.1
  • 5
    • 0037380886 scopus 로고    scopus 로고
    • Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia
    • Holst,C.R. et al. (2003) Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res., 63, 1596–1601.
    • (2003) Cancer Res , vol.63 , pp. 1596-1601
    • Holst, C.R.1
  • 6
    • 80355148407 scopus 로고    scopus 로고
    • Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk
    • Chen,W.Y. et al. (2011) Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA, 306, 1884–1890.
    • (2011) JAMA , vol.306 , pp. 1884-1890
    • Chen, W.Y.1
  • 7
    • 23144461860 scopus 로고    scopus 로고
    • Effects of alcohol on folate metabolism: implications for carcinogenesis
    • Mason,J.B. et al. (2005) Effects of alcohol on folate metabolism: implications for carcinogenesis. Alcohol, 35, 235–241.
    • (2005) Alcohol , vol.35 , pp. 235-241
    • Mason, J.B.1
  • 8
    • 33645377946 scopus 로고    scopus 로고
    • Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark
    • Tjønneland,A. et al. (2006) Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark. Eur. J. Clin. Nutr., 60, 280–286.
    • (2006) Eur. J. Clin. Nutr , vol.60 , pp. 280-286
    • Tjønneland, A.1
  • 9
    • 26644434598 scopus 로고    scopus 로고
    • Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study
    • Baglietto,L. et al. (2005) Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. BMJ, 331, 807.
    • (2005) BMJ , vol.331 , pp. 807
    • Baglietto, L.1
  • 10
    • 33646715354 scopus 로고    scopus 로고
    • Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    • Stolzenberg-Solomon,R.Z. et al. (2006) Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am. J. Clin. Nutr., 83, 895–904.
    • (2006) Am. J. Clin. Nutr , vol.83 , pp. 895-904
    • Stolzenberg-Solomon, R.Z.1
  • 11
    • 0034979766 scopus 로고    scopus 로고
    • Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women
    • Sellers,T.A. et al. (2001) Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology, 12, 420–428.
    • (2001) Epidemiology , vol.12 , pp. 420-428
    • Sellers, T.A.1
  • 12
    • 0037117501 scopus 로고    scopus 로고
    • A common mutation in the 5,10-methylenetetrahydro-folate reductase gene affects genomic DNA methylation through an interaction with folate status
    • Friso,S. et al. (2002) A common mutation in the 5,10-methylenetetrahydro-folate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc. Natl Acad. Sci. U S A, 99, 5606–5611.
    • (2002) Proc. Natl Acad. Sci. U S A , vol.99 , pp. 5606-5611
    • Friso, S.1
  • 13
    • 84860326556 scopus 로고    scopus 로고
    • Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies
    • Han,D. et al. (2012) Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies. Mol. Biol. Rep., 39, 805–816.
    • (2012) Mol. Biol. Rep , vol.39 , pp. 805-816
    • Han, D.1
  • 14
    • 84874252043 scopus 로고    scopus 로고
    • The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies
    • Teng,Z. et al. (2013) The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies. PLoS One, 8, e55332.
    • (2013) PLoS One , vol.8 , pp. e55332
    • Teng, Z.1
  • 15
    • 34247478510 scopus 로고    scopus 로고
    • Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses
    • Lissowska,J. et al. (2007) Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses. Int. J. Cancer, 120, 2696–2703.
    • (2007) Int. J. Cancer , vol.120 , pp. 2696-2703
    • Lissowska, J.1
  • 16
    • 70349317366 scopus 로고    scopus 로고
    • Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk
    • Platek,M.E. et al. (2009) Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk. Cancer Epidemiol. Biomarkers Prev., 18, 2453–2459.
    • (2009) Cancer Epidemiol. Biomarkers Prev , vol.18 , pp. 2453-2459
    • Platek, M.E.1
  • 17
    • 66149168707 scopus 로고    scopus 로고
    • Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women
    • Ma,E. et al. (2009) Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women. BMC Cancer, 9, 122.
    • (2009) BMC Cancer , vol.9 , pp. 122
    • Ma, E.1
  • 18
    • 34250845984 scopus 로고    scopus 로고
    • Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence
    • Stevens,V.L. et al. (2007) Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence. Cancer Epidemiol. Biomarkers Prev., 16, 1140–1147.
    • (2007) Cancer Epidemiol. Biomarkers Prev , vol.16 , pp. 1140-1147
    • Stevens, V.L.1
  • 19
    • 78649333472 scopus 로고    scopus 로고
    • MTRR A66G polymorphism and breast cancer risk: a meta-analysis
    • Hu,J. et al. (2010) MTRR A66G polymorphism and breast cancer risk: a meta-analysis. Breast Cancer Res. Treat., 124, 779–784.
    • (2010) Breast Cancer Res. Treat , vol.124 , pp. 779-784
    • Hu, J.1
  • 20
    • 56549088418 scopus 로고    scopus 로고
    • Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer
    • Kotsopoulos,J. et al. (2008) Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer. Breast Cancer Res. Treat., 112, 585–593.
    • (2008) Breast Cancer Res. Treat , vol.112 , pp. 585-593
    • Kotsopoulos, J.1
  • 21
    • 79952114981 scopus 로고    scopus 로고
    • Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women
    • Sangrajrang,S. et al. (2010) Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res. Treat., 123, 885–893.
    • (2010) Breast Cancer Res. Treat , vol.123 , pp. 885-893
    • Sangrajrang, S.1
  • 22
    • 33645514418 scopus 로고    scopus 로고
    • MTR and MTRR polymorphisms, dietary intake, and breast cancer risk
    • Shrubsole,M.J. et al. (2006) MTR and MTRR polymorphisms, dietary intake, and breast cancer risk. Cancer Epidemiol. Biomarkers Prev., 15, 586–588.
    • (2006) Cancer Epidemiol. Biomarkers Prev , vol.15 , pp. 586-588
    • Shrubsole, M.J.1
  • 23
    • 84858798306 scopus 로고    scopus 로고
    • Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk
    • Weiner,A.S. et al. (2012) Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk. Cancer Epidemiol., 36, e95–e100.
    • (2012) Cancer Epidemiol , vol.36 , pp. e95-e100
    • Weiner, A.S.1
  • 24
    • 40549098422 scopus 로고    scopus 로고
    • One-carbon metabolism-related gene polymorphisms and risk of breast cancer
    • Suzuki,T. et al. (2008) One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis, 29, 356–362.
    • (2008) Carcinogenesis , vol.29 , pp. 356-362
    • Suzuki, T.1
  • 25
    • 0024261270 scopus 로고
    • Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates
    • Horne,D.W. et al. (1988) Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. Clin. Chem., 34, 2357–2359.
    • (1988) Clin. Chem , vol.34 , pp. 2357-2359
    • Horne, D.W.1
  • 26
    • 0038678777 scopus 로고    scopus 로고
    • Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites
    • Colella,S. et al. (2003) Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques, 35, 146–150.
    • (2003) Biotechniques , vol.35 , pp. 146-150
    • Colella, S.1
  • 27
    • 0027394794 scopus 로고
    • Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer
    • Allred,D.C. et al. (1993) Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J. Natl Cancer Inst., 85, 200–206.
    • (1993) J. Natl Cancer Inst , vol.85 , pp. 200-206
    • Allred, D.C.1
  • 28
    • 0026597164 scopus 로고
    • Long-term folate deficiency alters folate content and distribution differentially in rat tissues
    • Varela-Moreiras,G. et al. (1992) Long-term folate deficiency alters folate content and distribution differentially in rat tissues. J. Nutr., 122, 986–991.
    • (1992) J. Nutr , vol.122 , pp. 986-991
    • Varela-Moreiras, G.1
  • 29
    • 0031656598 scopus 로고    scopus 로고
    • Hypomethylation in cervical tissue: is there a correlation with folate status?
    • Fowler,B.M. et al. (1998) Hypomethylation in cervical tissue: is there a correlation with folate status? Cancer Epidemiol. Biomarkers Prev., 7, 901–906.
    • (1998) Cancer Epidemiol. Biomarkers Prev , vol.7 , pp. 901-906
    • Fowler, B.M.1
  • 30
    • 77957329892 scopus 로고    scopus 로고
    • Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake
    • Christensen,B.C. et al. (2010) Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake. PLoS Genet., 6, e1001043.
    • (2010) PLoS Genet , vol.6 , pp. e1001043
    • Christensen, B.C.1
  • 31
    • 84857504660 scopus 로고    scopus 로고
    • Cellular senescence and tumor suppressor gene p16
    • Rayess,H. et al. (2012) Cellular senescence and tumor suppressor gene p16. Int. J. Cancer, 130, 1715–1725.
    • (2012) Int. J. Cancer , vol.130 , pp. 1715-1725
    • Rayess, H.1
  • 32
    • 84863230411 scopus 로고    scopus 로고
    • The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells
    • Bazarov,A.V. et al. (2012) The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells. Cell Cycle, 11, 1008–1013.
    • (2012) Cell Cycle , vol.11 , pp. 1008-1013
    • Bazarov, A.V.1
  • 33
    • 79961117100 scopus 로고    scopus 로고
    • The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments
    • Witkiewicz,A.K. et al. (2011) The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments. Cell Cycle, 10, 2497–2503.
    • (2011) Cell Cycle , vol.10 , pp. 2497-2503
    • Witkiewicz, A.K.1
  • 34
    • 80054682555 scopus 로고    scopus 로고
    • Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
    • Coppé,J.P. et al. (2011) Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J. Biol. Chem., 286, 36396–36403.
    • (2011) J. Biol. Chem , vol.286 , pp. 36396-36403
    • Coppé, J.P.1
  • 35
    • 80053290682 scopus 로고    scopus 로고
    • The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence
    • Li,N. et al. (2011) The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence. FEBS Lett., 585, 3106–3112.
    • (2011) FEBS Lett , vol.585 , pp. 3106-3112
    • Li, N.1
  • 36
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • Rodier,F. et al. (2009) Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol., 11, 973–979.
    • (2009) Nat. Cell Biol , vol.11 , pp. 973-979
    • Rodier, F.1
  • 37
    • 77952009891 scopus 로고    scopus 로고
    • Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer
    • Radpour,R. et al. (2010) Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer. Mod. Pathol., 23, 763–772.
    • (2010) Mod. Pathol , vol.23 , pp. 763-772
    • Radpour, R.1
  • 38
    • 78349273669 scopus 로고    scopus 로고
    • p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells
    • Bazarov,A.V. et al. (2010) p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell, 9, 736–746.
    • (2010) Aging Cell , vol.9 , pp. 736-746
    • Bazarov, A.V.1
  • 39
    • 67449158992 scopus 로고    scopus 로고
    • Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization
    • Novak,P. et al. (2009) Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res., 69, 5251–5258.
    • (2009) Cancer Res , vol.69 , pp. 5251-5258
    • Novak, P.1
  • 40
    • 84865433349 scopus 로고    scopus 로고
    • DNA damage checkpoints in stem cells, ageing and cancer
    • Sperka,T. et al. (2012) DNA damage checkpoints in stem cells, ageing and cancer. Nat. Rev. Mol. Cell Biol., 13, 579–590.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 579-590
    • Sperka, T.1
  • 41
    • 84859157639 scopus 로고    scopus 로고
    • Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer
    • Arima,Y. et al. (2012) Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer. Int. J. Cancer, 130, 2568–2579.
    • (2012) Int. J. Cancer , vol.130 , pp. 2568-2579
    • Arima, Y.1
  • 42
    • 33646949481 scopus 로고    scopus 로고
    • DNA hypermethylation in breast cancer and its association with clinicopathological features
    • Li,S. et al. (2006) DNA hypermethylation in breast cancer and its association with clinicopathological features. Cancer Lett., 237, 272–280.
    • (2006) Cancer Lett , vol.237 , pp. 272-280
    • Li, S.1
  • 43
    • 84896722414 scopus 로고    scopus 로고
    • The molecular balancing act of p16(INK4a) in cancer and aging
    • LaPak,K.M. et al. (2014) The molecular balancing act of p16(INK4a) in cancer and aging. Mol. Cancer Res., 12, 167–183.
    • (2014) Mol. Cancer Res , vol.12 , pp. 167-183
    • LaPak, K.M.1
  • 44
    • 79251594654 scopus 로고    scopus 로고
    • Promoter methylation and expression changes of CDH1 and P16 genes in invasive breast cancer and adjacent normal breast tissue
    • Celebiler Cavusoglu,A. et al. (2010) Promoter methylation and expression changes of CDH1 and P16 genes in invasive breast cancer and adjacent normal breast tissue. Neoplasma, 57, 465–472.
    • (2010) Neoplasma , vol.57 , pp. 465-472
    • Celebiler Cavusoglu, A.1
  • 45
    • 84868368069 scopus 로고    scopus 로고
    • Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls
    • Sturgeon,S.R. et al. (2012) Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls. Epigenetics, 7, 1258–1267.
    • (2012) Epigenetics , vol.7 , pp. 1258-1267
    • Sturgeon, S.R.1
  • 46
    • 79959195994 scopus 로고    scopus 로고
    • The association between two polymorphisms in the TYMS gene and breast cancer risk: a meta-analysis
    • Wang,J. et al. (2011) The association between two polymorphisms in the TYMS gene and breast cancer risk: a meta-analysis. Breast Cancer Res. Treat., 128, 203–209.
    • (2011) Breast Cancer Res. Treat , vol.128 , pp. 203-209
    • Wang, J.1
  • 47
    • 0032935312 scopus 로고    scopus 로고
    • The relation of breast size to breast cancer risk in postmenopausal women (United States)
    • Egan,K.M. et al. (1999) The relation of breast size to breast cancer risk in postmenopausal women (United States). Cancer Causes Control, 10, 115–118.
    • (1999) Cancer Causes Control , vol.10 , pp. 115-118
    • Egan, K.M.1
  • 48
    • 33645243801 scopus 로고    scopus 로고
    • A prospective study of breast size and premenopausal breast cancer incidence
    • Kusano,A.S. et al. (2006) A prospective study of breast size and premenopausal breast cancer incidence. Int. J. Cancer, 118, 2031–2034.
    • (2006) Int. J. Cancer , vol.118 , pp. 2031-2034
    • Kusano, A.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.