The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence

FEBS Letters

Volumn 585, Issue 19, 2011, Pages 3106-3112

  Li, Na ^a   Li, Qian ^a   Cao, Xiaoxiao ^a   Zhao, Ganye ^a   Xue, Lixiang ^a   Tong, Tanjun ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cellular senescence; HAT; p16INK4a; p33ING1b

Indexed keywords

CURCUMIN; ISOPROTEIN; PROTEIN ING1; PROTEIN P16; PROTEIN P300; PROTEIN P33; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE INHIBITOR 2A; ENZYME INHIBITOR; HISTONE ACETYLTRANSFERASE PCAF; ING1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL PEPTIDE;

ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; FIBROBLAST; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SENESCENCE; CELL AGING; CELL LINE; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROMOTER REGION;

CELL AGING; CELL LINE; CURCUMIN; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ENZYME INHIBITORS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; TUMOR SUPPRESSOR PROTEINS;

EID: 80053290682     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.08.044     Document Type: Article

References (24)

1. M. Russell, P. Berardi, W. Gong, and K. Riabowol Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis Exp. Cell Res. 312 2006 951 961
2. I. Garkavtsev, A. Kazarov, A. Gudkov, and K. Riabowol Suppression of the novel growth inhibitor p33(ING1) promotes neoplastic transformation Nat. Genet. 14 1996 415 420 (Pubitemid 26414585)
3. A. Saito, T. Furukawa, S. Fukushige, S. Koyama, M. Hoshi, Y. Hayashi, and A. Horii P24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1 J. Hum. Genet. 45 2000 177 181 (Pubitemid 30324121)
4. H. Kataoka ING1 represses transcription by direct DNA binding and through effects on p53 Cancer Res. 63 2003 5785 5792 (Pubitemid 37187475)
5. K.M. Leung, L.S. Po, F.C. Tsang, W.Y. Sin, A. Lau, H. Ho, and R. Poon The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 Cancer Res. 62 2002 4890 4893 (Pubitemid 34984409)
6. F.C. Tsang, L.S. Po, K.M. Leung, A. Lau, W.Y. Siu, and R. Poon ING1b decreases cell proliferation through p53-dependent and -independent mechanisms FEBS Lett. 553 2003 277 285 (Pubitemid 37315617)
7. A.H. Coles, H.L. Liang, Z.Q. Zhu, C.G. Marfella, J. Kang, A.N. Imbalzano, and S.N. Jones Deletion of p37(Ing1) in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis Cancer Res. 67 2007 2054 2061 (Pubitemid 46424223)
8. D. Vieyra Human ING1 proteins differentially regulate histone acetylation J. Biol. Chem. 277 2002 29832 29839
9. D. Skowyra Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex J. Biol. Chem. 276 2001 8734 8739
10. A. Kuzmichev, Y. Zhang, H. Erdjument-Bromage, P. Tempst, and D. Reinberg Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) Mol. Cell Biol. 22 2002 835 848 (Pubitemid 34053062)
11. I. Garkavtsev, and K. Riabowol Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33(ING1) candidate tumor suppressor Mol. Cell Biol. 17 1997 2014 2019 (Pubitemid 27133286)
12. F. Goeman, D. Thormeyer, M. Abad, M. Serrano, O. Schmidt, I. Palmero, and A. Baniahmad Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: Involvement of two silencing domains and effect of Ras Mol. Cell Biol. 25 2005 422 431 (Pubitemid 40039831)
13. M. Abad, A. Moreno, A. Palacios, M. Narita, F. Blanco, G. Moreno-Bueno, M. Narita, and I. Palmero The tumor suppressor ING1 contributes to epigenetic control of cellular senescence Aging Cell 10 2011 158 171
14. M.A. Soliman, P. Berardi, S. Pastyryeva, P. Bonnefin, X. Feng, A. Colina, D. Young, and K. Riabowol ING1a expression increases during replicative senescence and induces a senescent phenotype Aging Cell 7 2008 783 794 (Pubitemid 352749433)
15. L.X. Xue, J.F. Wu, W.J. Zheng, P.C. Wang, J. Li, Z.Y. Zhang, and T.J. Tong Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in HeLa cells FEBS Lett. 564 2004 199 204 (Pubitemid 38490724)
16. W. Wang, J.F. Wu, Z.Y. Zhang, and T.J. Tong Characterization of regulatory elements on the promoter region of p16(INK4a) that contribute to overexpression of p16 in senescent fibroblasts J. Biol. Chem. 276 2001 48655 48661
17. M. Narita, M. Narita, V. Krizhanovsky, S. Nuñez, A. Chicas, S.A. Hearn, M.P. Myers, and S.W. Lowe A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation Cell 126 2006 503 514 (Pubitemid 44163608)
18. R. Zhou, L.M. Han, G.D. Li, and T.J. Tong Senescence delay and repression of p16(INK4a) by Lsh via recruitment of histone deacetylases in human diploid fibroblasts Nucleic Acids Res. 37 2009 5183 5196
19. K. Balasubramanyam, R.A. Varier, M. Altaf, V. Swaminathan, N.B. Siddappa, U. Ranga, and T.K. Kundu Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription J. Biol. Chem. 279 2004 51163 51171 (Pubitemid 40017859)
20. M.G. Marcu, Y.J. Jung, S. Lee, E.J. Chung, M.J. Lee, J. Trepel, and L. Neckers Curcumin is an inhibitor of p300 histone acetylatransferase Med. Chem. 2 2006 169 174 (Pubitemid 44083157)
21. W. Gong, K. Suzuki, M. Russell, and K. Riabowol Function of the ING family of PHD proteins in cancer Int. J. Biochem. Cell B. 37 2005 1054 1065 (Pubitemid 40311746)
22. INK4a transcription Cell. Mol. Life Sci. 68 2011 893 901
23. INK4a expression by Id1 and E47 proteins in human diploid fibroblast J. Biol. Chem. 279 2004 31524 31532
24. INK4a expression in human diploid fibroblasts J. Cell Sci. 121 2008 2235 2245