-
1
-
-
27644439209
-
Anoikis
-
(suppl. 2)
-
Gilmore,A.P. (2005) Anoikis. Cell Death Differ., 12 (suppl. 2), 1473–1477.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1473-1477
-
-
Gilmore, A.P.1
-
2
-
-
0036016923
-
Molecular mechanisms of “detachment-induced apoptosis–Anoikis”
-
Grossmann,J. (2002) Molecular mechanisms of “detachment-induced apoptosis–Anoikis”. Apoptosis, 7, 247–260.
-
(2002)
Apoptosis
, vol.7
, pp. 247-260
-
-
Grossmann, J.1
-
3
-
-
0035480032
-
Anoikis mechanisms
-
Frisch,S.M. et al. (2001) Anoikis mechanisms. Curr. Opin. Cell Biol., 13, 555–562.
-
(2001)
Curr. Opin. Cell Biol
, vol.13
, pp. 555-562
-
-
Frisch, S.M.1
-
4
-
-
55949136859
-
Anoikis resistance and tumor metastasis
-
Simpson,C.D. et al. (2008) Anoikis resistance and tumor metastasis. Cancer Lett., 272, 177–185.
-
(2008)
Cancer Lett
, vol.272
, pp. 177-185
-
-
Simpson, C.D.1
-
5
-
-
78449281238
-
Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death
-
Coates,J.M. et al. (2010) Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death. J. Surg. Res., 164, 301–308.
-
(2010)
J. Surg. Res
, vol.164
, pp. 301-308
-
-
Coates, J.M.1
-
6
-
-
0030046753
-
STATs: signal transducers and activators of transcription
-
Ihle,J.N. (1996) STATs: signal transducers and activators of transcription. Cell, 84, 331–334.
-
(1996)
Cell
, vol.84
, pp. 331-334
-
-
Ihle, J.N.1
-
7
-
-
0030840464
-
STATs and gene regulation
-
Darnell,J.E. Jr. (1997) STATs and gene regulation. Science, 277, 1630–1635.
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Darnell, J.E.1
-
8
-
-
0030962017
-
The state of the STATs: recent developments in the study of signal transduction to the nucleus
-
Horvath,C.M. et al. (1997) The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr. Opin. Cell Biol., 9, 233–239.
-
(1997)
Curr. Opin. Cell Biol
, vol.9
, pp. 233-239
-
-
Horvath, C.M.1
-
9
-
-
0031024108
-
STAT signaling is active during early mammalian development
-
Duncan,S.A. et al. (1997) STAT signaling is active during early mammalian development. Dev. Dyn., 208, 190–198.
-
(1997)
Dev. Dyn
, vol.208
, pp. 190-198
-
-
Duncan, S.A.1
-
10
-
-
0033529704
-
Stat3 as an oncogene
-
Bromberg,J.F. et al. (1999) Stat3 as an oncogene. Cell, 98, 295–303.
-
(1999)
Cell
, vol.98
, pp. 295-303
-
-
Bromberg, J.F.1
-
11
-
-
0036469065
-
Signal transduction and the control of gene expression
-
Brivanlou,A.H. et al. (2002) Signal transduction and the control of gene expression. Science, 295, 813–818.
-
(2002)
Science
, vol.295
, pp. 813-818
-
-
Brivanlou, A.H.1
-
12
-
-
0038820386
-
Signal transducer and activator of transcription proteins in leukemias
-
Benekli,M. et al. (2003) Signal transducer and activator of transcription proteins in leukemias. Blood, 101, 2940–2954.
-
(2003)
Blood
, vol.101
, pp. 2940-2954
-
-
Benekli, M.1
-
13
-
-
35348893870
-
Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy
-
Germain,D. et al. (2007) Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin. Cancer Res., 13, 5665–5669.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 5665-5669
-
-
Germain, D.1
-
14
-
-
0033781642
-
Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells
-
Huang,M. et al. (2000) Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. Gynecol. Oncol., 79, 67–73.
-
(2000)
Gynecol. Oncol
, vol.79
, pp. 67-73
-
-
Huang, M.1
-
15
-
-
0034658698
-
STATs in oncogenesis
-
Bowman,T. et al. (2000) STATs in oncogenesis. Oncogene, 19, 2474–2488.
-
(2000)
Oncogene
, vol.19
, pp. 2474-2488
-
-
Bowman, T.1
-
16
-
-
0034658551
-
The role of STATs in myeloid differentiation and leukemia
-
Coffer,P.J. et al. (2000) The role of STATs in myeloid differentiation and leukemia. Oncogene, 19, 2511–2522.
-
(2000)
Oncogene
, vol.19
, pp. 2511-2522
-
-
Coffer, P.J.1
-
17
-
-
0034658499
-
STAT signaling in head and neck cancer
-
Song,J.I. et al. (2000) STAT signaling in head and neck cancer. Oncogene, 19, 2489–2495.
-
(2000)
Oncogene
, vol.19
, pp. 2489-2495
-
-
Song, J.I.1
-
18
-
-
18644380911
-
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
-
Niu,G. et al. (2002) Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene, 21, 7001–7010.
-
(2002)
Oncogene
, vol.21
, pp. 7001-7010
-
-
Niu, G.1
-
19
-
-
0036731485
-
Stats: transcriptional control and biological impact
-
Levy,D.E. et al. (2002) Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol., 3, 651–662.
-
(2002)
Nat. Rev. Mol. Cell Biol
, vol.3
, pp. 651-662
-
-
Levy, D.E.1
-
20
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell,J.E. Jr. (2002) Transcription factors as targets for cancer therapy. Nat. Rev. Cancer, 2, 740–749.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 740-749
-
-
Darnell, J.E.1
-
21
-
-
20944441928
-
Validating Stat3 in cancer therapy
-
Darnell,J.E. (2005) Validating Stat3 in cancer therapy. Nat. Med., 11, 595–596.
-
(2005)
Nat. Med
, vol.11
, pp. 595-596
-
-
Darnell, J.E.1
-
22
-
-
0035136846
-
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
-
Epling-Burnette,P.K. et al. (2001) Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J. Clin. Invest., 107, 351–362.
-
(2001)
J. Clin. Invest
, vol.107
, pp. 351-362
-
-
Epling-Burnette, P.K.1
-
23
-
-
31544458469
-
Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
-
Gritsko,T. et al. (2006) Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin. Cancer Res., 12, 11–19.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 11-19
-
-
Gritsko, T.1
-
24
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal,A. et al. (2010) Cancer statistics, 2010. CA. Cancer J. Clin., 60, 277–300.
-
(2010)
CA. Cancer J. Clin
, vol.60
, pp. 277-300
-
-
Jemal, A.1
-
25
-
-
1642588228
-
Pancreatic cancer
-
Li,D. et al. (2004) Pancreatic cancer. Lancet, 363, 1049–1057.
-
(2004)
Lancet
, vol.363
, pp. 1049-1057
-
-
Li, D.1
-
26
-
-
49349104165
-
Molecular targeted therapies for pancreatic cancer
-
Borja-Cacho,D. et al. (2008) Molecular targeted therapies for pancreatic cancer. Am. J. Surg., 196, 430–441.
-
(2008)
Am. J. Surg
, vol.196
, pp. 430-441
-
-
Borja-Cacho, D.1
-
27
-
-
79959891751
-
Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis
-
Besmer,D.M. et al. (2011) Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis. Cancer Res., 71, 4432–4442.
-
(2011)
Cancer Res
, vol.71
, pp. 4432-4442
-
-
Besmer, D.M.1
-
28
-
-
84865417726
-
Apoptosis signal-regulating kinase 1-thiore-doxin complex dissociation by capsaicin causes pancreatic tumor growth suppressionbyinducingapoptosis
-
Pramanik,K.C. et al. (2012) Apoptosis signal-regulating kinase 1-thiore-doxin complex dissociation by capsaicin causes pancreatic tumor growth suppressionbyinducingapoptosis.Antioxid.RedoxSignal.,17,1417–1432.
-
(2012)
Antioxid.RedoxSignal
, vol.17
, pp. 1417-1432
-
-
Pramanik, K.C.1
-
29
-
-
84883154324
-
Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model
-
Boreddy,S.R. et al. (2013) Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model. Oncogene, 32, 3980–3991.
-
(2013)
Oncogene
, vol.32
, pp. 3980-3991
-
-
Boreddy, S.R.1
-
30
-
-
84879533925
-
Metastasis of breast tumor cells to brain is suppressed by phenethyl isothiocyanate in a novel in vivo metastasis model
-
Gupta,P. et al. (2013) Metastasis of breast tumor cells to brain is suppressed by phenethyl isothiocyanate in a novel in vivo metastasis model. PLoS One, 8, e67278.
-
(2013)
PLoS One
, vol.8
, pp. e67278
-
-
Gupta, P.1
-
31
-
-
80053925842
-
Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/RhoGTPases: pivotal role of STAT-3
-
Boreddy,S.R. et al. (2011) Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/RhoGTPases: pivotal role of STAT-3. PLoS One, 6, e25799.
-
(2011)
PLoS One
, vol.6
, pp. e25799
-
-
Boreddy, S.R.1
-
32
-
-
84865217843
-
Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo
-
Kandala,P.K. et al. (2012) Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo. J. Biol. Chem., 287, 28745–28754.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 28745-28754
-
-
Kandala, P.K.1
-
33
-
-
84858658094
-
Blocking epidermal growth factor receptor activation by 3,3’-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo
-
Kandala,P.K. et al. (2012) Blocking epidermal growth factor receptor activation by 3,3’-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J. Pharmacol. Exp. Ther., 341, 24–32.
-
(2012)
J. Pharmacol. Exp. Ther
, vol.341
, pp. 24-32
-
-
Kandala, P.K.1
-
34
-
-
59749104966
-
The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate
-
Sahu,R.P. et al. (2009) The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J. Natl. Cancer Inst., 101, 176–193.
-
(2009)
J. Natl. Cancer Inst
, vol.101
, pp. 176-193
-
-
Sahu, R.P.1
-
35
-
-
84867888901
-
Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models
-
Gupta,P. et al. (2012) Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models. BMC Med., 10, 80.
-
(2012)
BMC Med
, vol.10
, pp. 80
-
-
Gupta, P.1
-
36
-
-
79953293746
-
Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway
-
Boreddy,S.R. et al. (2011) Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin. Cancer Res., 17, 1784–1795.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 1784-1795
-
-
Boreddy, S.R.1
-
37
-
-
84856085484
-
Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3)
-
Kandala,P.K. et al. (2012) Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3). BMC Med., 10, 9.
-
(2012)
BMC Med
, vol.10
, pp. 9
-
-
Kandala, P.K.1
-
38
-
-
84896264601
-
CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT
-
Pramanik,K.C. et al. (2014) CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol. Cancer Ther., 13, 687–698.
-
(2014)
Mol. Cancer Ther
, vol.13
, pp. 687-698
-
-
Pramanik, K.C.1
-
39
-
-
84907086036
-
Critical role of STAT3 in melanoma metastasis through anoikis resistance
-
Fofaria,N.M. et al. (2014) Critical role of STAT3 in melanoma metastasis through anoikis resistance. Oncotarget, 5, 7051–7064.
-
(2014)
Oncotarget
, vol.5
, pp. 7051-7064
-
-
Fofaria, N.M.1
-
40
-
-
77952711940
-
Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation
-
Cheng,H.L. et al. (2010) Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation. Mol. Cancer, 9, 126.
-
(2010)
Mol. Cancer
, vol.9
, pp. 126
-
-
Cheng, H.L.1
-
41
-
-
70350566519
-
Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma
-
Du,X.L. et al. (2009) Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma. Oncogene, 28, 3714–3722.
-
(2009)
Oncogene
, vol.28
, pp. 3714-3722
-
-
Du, X.L.1
-
42
-
-
66449127943
-
Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling
-
Neiva,K.G. et al. (2009) Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling. Neoplasia, 11, 583–593.
-
(2009)
Neoplasia
, vol.11
, pp. 583-593
-
-
Neiva, K.G.1
-
43
-
-
77951710240
-
Phenotype and genotype of pancreatic cancer cell lines
-
Deer,E.L. et al. (2010) Phenotype and genotype of pancreatic cancer cell lines. Pancreas, 39, 425–435.
-
(2010)
Pancreas
, vol.39
, pp. 425-435
-
-
Deer, E.L.1
-
44
-
-
23044515381
-
Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines
-
Gysin,S. et al. (2005) Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines. Genes. Chromosomes Cancer, 44, 37–51.
-
(2005)
Genes. Chromosomes Cancer
, vol.44
, pp. 37-51
-
-
Gysin, S.1
|