Functional urological disorders: A sensitized defence response in the bladder-gut-brain axis

Nature Reviews Urology

Volumn 14, Issue 3, 2017, Pages 153-163

  Leue, Carsten ^a   Kruimel, Joanna ^a   Vrijens, Desiree ^a   Masclee, Adrian ^a   Van Os, Jim ^a   Van Koeveringe, Gommert ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANXIETY; ANXIETY DISORDER; BEHAVIOR; BLADDER; BLADDER DISEASE; BRAIN; CHRONIC PROSTATITIS; COGNITION; COMORBIDITY; CYSTALGIA; DEPRESSION; DYSBIOSIS; EMOTIONAL STRESS; FUNCTIONAL DISEASE; FUNCTIONAL UROLOGICAL DISORDER; GASTROINTESTINAL DISEASE; HOMEOSTASIS; HUMAN; INFECTION; INFLAMMATORY BOWEL DISEASE; INTERSTITIAL CYSTITIS; INTESTINE; MENTAL DISEASE; MENTAL STRESS; MICROFLORA; MOOD DISORDER; NEUROSIS; OVERACTIVE BLADDER; PELVIS PAIN SYNDROME; PHENOTYPE; PSYCHOLOGICAL ASPECT; REVIEW; RISK FACTOR; TREATMENT OUTCOME; URINARY TRACT DISEASE; AFFECT; GASTROINTESTINAL TRACT; INNERVATION; NERVE TRACT; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY;

AFFECT; BRAIN; GASTROINTESTINAL TRACT; HUMANS; NEURAL PATHWAYS; URINARY BLADDER; UROLOGIC DISEASES;

EID: 85001969723     PISSN: 17594812     EISSN: 17594820     Source Type: Journal    
DOI: 10.1038/nrurol.2016.227     Document Type: Review

References (240)

1. Chung, M. K., et al. The overlap of interstitial cystitis/painful bladder syndrome and overactive bladder. JSLS 14, 83-90 (2010).
2. Lai, H. H., et al. The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder. A questionnaire based analysis. J. Urol. 192, 1679-1685 (2014).
3. Suskind, A. M., et al. The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology male study. J. Urol. 189, 141-145 (2013).
4. Matsumoto, S., et al. Relationship between overactive bladder and irritable bowel syndrome: a large-scale internet survey in Japan using the overactive bladder symptom score and Rome III criteria. BJU Int. 111, 647-652 (2013).
5. Matsuzaki, J., et al. High frequency of overlap between functional dyspepsia and overactive bladder. Neurogastroenterol. Motil. 24, 821-827 (2012).
6. Chelimsky, G., et al. Co-morbidities of interstitial cystitis. Front. Neurosci. 6, 114 (2012).
7. Fan, Y. H., et al. Non-bladder conditions in female Taiwanese patients with interstitial cystitis/hypersensitive bladder syndrome. Int. J. Urol. 21, 805-809 (2014).
8. Persson, R., et al. The relationship between irritable bowel syndrome, functional dyspepsia, chronic fatigue and overactive bladder syndrome: a controlled study 6 years after acute gastrointestinal infection. BMC Gastroenterol. 15, 66 (2015).
9. Lai, H. H., et al. Polysymptomatic, polysyndromic presentation of patients with urological chronic pelvic pain syndrome. J. Urol. 187, 2106-2112 (2012).
10. Fuoco, M. B., et al. Multiple sensitivity phenotype in interstitial cystitis/bladder pain syndrome. Can. Urol. Assoc. J. 8, 758-761 (2014).
11. Bullones Rodriguez, M. A., et al. Evidence for overlap between urological and nonurological unexplained clinical conditions. J. Urol. 189, S66-S74 (2013).
12. Kanaan, R. A., et al. The association or otherwise of the functional somatic syndromes. Psychosom. Med. 69, 855-889 (2007).
13. Fink, P., Schröder, A. One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders. J. Psychosom. Res. 68, 415-426 (2010).
14. Wessely, S., White, P. D. There is only one functional somatic syndrome. Br. J. Psychiatry 185, 95-96 (2004).
15. Mahadeva, S., Goh, K. L. Epidemiology of functional dyspepsia: a global perspective. World J. Gastroenterol. 12, 2661-2666 (2006).
16. Saito, Y. A., et al. The epidemiology of irritable bowel syndrome in North America: a systematic review. Am. J. Gastroenterol. 97, 1910-1915 (2002).
17. Agarwal, N., Spiegel, B. M. The effect of irritable bowel syndrome on health-related quality of life and health care expenditures. Gastroenterol. Clin. North Am. 40, 11-19 (2011).
18. Fortea, J., Prior, M. Irritable bowel syndrome with constipation: a European-focused systematic literature review of disease burden. J. Med. Econ. 16, 329-341 (2013).
19. Milsom, I., et al. The prevalence of overactive bladder. Am. J. Manag. Care 6, S565-S573 (2000).
20. Tikkinen, K. A., et al. Is the prevalence of overactive bladder overestimated? A population-based study in Finland. PLoS ONE 2, e195 (2007).
21. Coyne, K. S., et al. Economic burden of urgency urine incontinence in the United States: a systematic review. J. Manag. Care Pharm. 20, 130-140 (2014).
22. Reynolds, W. S., et al. The burden of overactive bladder on US public health. Curr. Bladder Dysfunct. Rep. 11, 8-13 (2016).
23. El-Serag, H. B., et al. Systematic review: natural history of irritable bowel syndrome. Aliment. Pharmacol. Ther. 19, 861-870 (2004).
24. Giarensis, I., Cardozo, L. Management of refractory overactive bladder. Minerva Ginecol. 65, 41-52 (2013).
25. Mullins, C., et al. Novel research approaches for interstitial cystitis/bladder pain syndrome: thinking beyond the bladder. Transl Androl. Urol. 4, 524-533 (2015).
26. Goldman, H. B., et al. Defining response and non-response to treatment in patients with overactive bladder: a systematic review. Curr. Med. Res. Opin. 30, 509-526 (2014).
27. Kim, S. E., Chang, L. Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms? Neurogastroenterol. Motil. 24, 895-913 (2012).
28. Warren, J. W., et al. The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs. J. Psychosom. Res. 74, 12-17 (2013).
29. Warren, J. W., et al. Before the onset of interstitial/bladder pain syndrome, the presence of multiple non-bladder syndromes is strongly associated with a history of multiple surgeries. J. Psychosom. Res. 76, 75-79 (2014).
30. Warren, J. W., et al. Functional somatic syndromes as risk factors for hysterectomy in early bladder pain syndrome interstitial cystitis. J. Psychosom. Res. 77, 363-367 (2014).
31. Drossman, D. A. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130, 1377-1390 (2006).
32. Longstreth, G. F., et al. Functional bowel disorders. Gastroenterology 130, 1480-1491 (2006).
33. Abrams, P., et al. The standardisation of terminology of lower urinary tract function: report from the standardisation subcommitee of the International Continence Society. Neurourol. Urodyn. 21, 167-178 (2002).
34. Fall, M., et al. EAU guidelines on chronic pelvic pain. Eur. Urol. 46, 681-689 (2004).
35. van de Merwe, J. P., et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur. Urol. 53, 60-67 (2008).
36. van Ophoven, A., et al. [From end-organ disease to a classable bladder pain syndrome: paradigm shift in the understanding of urological pain syndromes exemplified by the condition currently called interstitial cystitis]. Urologe A 48, 152-162 (in German) (2009).
37. Fall, M., et al. EAU guidelines on chronic pelvic pain. Eur. Urol. 57, 35-48 (2010).
38. Engeler, D. S., et al. The 2013 EAU guidelines on chronic pelvic pain: is management of chronic pelvic pain a habbit, a philosophy, or a science? 10 years of development. Eur. Urol. 64, 431-439 (2013).
39. Wesselmann, U. A new paradigm in chronic bladder pain. J. Pain Palliat. Care Pharmacother. 28, 406-408 (2014).
40. Twiddy, H., et al. The development and delivery of a female chronic pelvic pain management programme: a specialised interdisciplinary approach. Br. J. Pain 9, 233-240 (2015).
41. Hanno, P. M., et al. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment. J. Urol. 193, 1545-1553 (2015).
42. Parsons, C. L. The role of a leaky epithelium and potassium in the generation of bladder symotoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. BJU Int. 107, 370-375 (2011).
43. Homma, Y. Hypersensitive bladder: a solution to confused terminology and ignorance concerning interstitial cystitis. Int. J. Urol. 21, S41-S47 (2014).
44. Hurst, R. E., et al. Increased bladder permeability in interstitial cystitis/painful bladder syndrome. Transl Androl. Urol. 5, 563-571 (2015).
45. Camilleri, M., Gorman, H. Intestinal permeability and irritable bowel syndrome. Neurogastroenterol. Motil. 19, 545-552 (2007).
46. Das, R., et al. Dimensions of sensation assessed in urinary urgency: a systematic review. J. Urol. 190, 1165-1172 (2013).
47. Juszczak, K., et al. Hyperosmolarity alters micturition: a comparison of urinary bladder motor activity in hyperosmolar and cyclophosphamide-induced models of overactive bladder. Can. J. Physiol. Pharmacol. 88, 899-906 (2010).
48. Greenwood-van Meerveld, B., et al. Mechanisms of visceral organ crosstalk: importance of alterations in permeability in rodent models. J. Urol. 194, 804-811 (2015).
49. Yoshikawa, S., et al. Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis. Neuroscience 284, 422-429 (2015).
50. Stanghellini, V., et al. Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome. Am. J. Gastroenterol. 97, 2738-2743 (2002).
51. Valentino, R. J., et al. The bladder-brain connection: putative role of corticotropin-releasing factor. Nat. Rev. Urol. 8, 19-28 (2011).
52. Martinez-Martinez, L. A., et al. Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies. J. Clin. Rheumatol. 20, 146-150 (2014).
53. Williams, D. P. Effects of chronic pelvic pain on heart rate variability in women. J. Urol. 194, 1289-1294 (2015).
54. Hughes, P. A., et al. Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms? Am. J. Gastroenterol. 108, 1066-1074 (2013).
55. Cartwright, R., et al. Novel biomarkers for overactive bladder. Nat. Rev. Urol. 8, 139-145 (2011).
56. Qu, H. C., et al. Association between polymorphism of ?3-adrenoceptor gene and overactive bladder: a meta-analysis. Genet. Mol. Res. 14, 2495-2501 (2015).
57. Talati, A., et al. Panic disorder, social anxiety disorder, and a possible medical syndrome previously linked to chromosome 13. Biol. Psychiatry 63, 594-601 (2008).
58. Villani, A. C., et al. Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis. Gastroenterology 138, 1502-1513 (2010).
59. Whiteside, S. A., et al. The microbiome of the urinary tract-a role beyond infection. Nat. Rev. Urol. 12, 81-90 (2015).
60. Pierce, A. N., Christianson, J. A. Stress and chronic pelvic pain. Prog. Mol. Biol. Transl Sci. 131, 509-535 (2015).
61. Mykletun, A., et al. Prevalence of mood and anxiety disorder in self-reported irritable bowel syndrome (IBS). An epidemiological population based study of women. BMC Gastroenterol. 10, 88 (2010).
62. Vrijens, D., et al. Affective symptoms and the overactive bladder-a systematic review. J. Psychosom. Res. 78, 95-108 (2015).
63. Choung, R. S., et al. Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: a psychosocial component is the rule. Am. J. Gastroenterol. 104, 1772-1779 (2009).
64. Koloski, N. A., et al. Does psychological distress modulate functional gastrointestinal symptoms and health care seeking? Am. J. Gastroenterol. 98, 789-797 (2003).
65. Lackner, J. M., et al. Testing the sequential model of pain processing in irritable bowel syndrome: a structural equation modeling analysis. Eur. J. Pain 9, 207-218 (2005).
66. Koloski, N. A., et al. What level of IBS symptoms drives impairment in health-related quality of life in community subjects with irritable bowel syndrome? Are current IBS syndrome thresholds clinically meaningful? Qual. Life Res. 21, 829-836 (2012).
67. Link, C. L., et al. Is abuse causally related to urologic symptoms? Results from the Boston Area Community Health (BACH) survey. Eur. Urol. 52, 397-406 (2007).
68. Rothrock, N. E., et al. Stress and symptomatology in patients with interstitial cystitis: a life stress model. Urology 57, 422-427 (2001).
69. Hsiao, S. M., et al. Psychometric assessment of female overactive bladder syndrome and antimuscarinics-related effects. Maturitas 79, 428-434 (2014).
70. Lai, H. H., et al. Urological symptoms in a subset of patients with urological chronic pelvic pain syndrome and a polysymptomatic, polysyndromatic pattern of presentation. J. Urol. 191, 1802-1807 (2014).
71. Krieger, J. N., et al. Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study. J. Urol. 193, 1254-1262 (2015).
72. Lackner, J. M., et al. The impact of physical complaints, social environment, and physical functioning on IBS patients' health perception: looking beyond GI symptom severity. Am. J. Gastroenterol. 109, 224-233 (2014).
73. Riegel, B., et al. Assessing psychological factors, social aspects and psychiatric co-morbidity associated with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in men-a systematic review. J. Psychosom. Res. 77, 333-350 (2014).
74. olde Hartman, T. C., et al. Chronic functional somatic symptoms: a single syndrome? Br. J. Gen. Pract. 54, 922-927 (2004).
75. Lackner, J. M. Type, rather than number, of mental physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 11, 1147-1157 (2013).
76. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 5th edn (American Psychiatric Publishing, 2013).
77. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research (World Health Organization, 1993).
78. Jylhä, P., Isometsä, E. The relationship of neuroticism and extraversion to symptoms of anxiety and depression in the general population. Depress. Anxiety 23, 281-289 (2006).
79. Klein, D. N., et al. Personality and depression: explanatory models and review of the evidence. Annu. Rev. Clin. Psychol. 7, 269-295 (2011).
80. Neeleman, J., et al. The distribution of psychiatric and somatic ill health: associations with personality and socioeconomic status. Psychosom. Med. 63, 239-247 (2001).
81. Lai, H. H., et al. Painful bladder filling and painful urgency are distinct characteristics in men and women with urological chronic pelvic pain syndromes: a MAPP research network study. J. Urol. 194, 1634-1641 (2015).
82. Koh, J. S., et al. The association of personality trait on treatment outcomes in patients with chronic prostatitis/chronic pelvic pain syndrome: an exploratory study. J. Psychosom. Res. 76, 127-133 (2014).
83. Koh, J. S., et al. The impact of depression and somatic symptoms on treatment outcomes in patients with chronic prostatitis/chronic pelvic pain syndrome: a preliminary study in a naturalistic treatment setting. Int. J. Clin. Pract. 68, 478-485 (2014).
84. Tayama, J., et al. Effects of personality traits on the manifestations of irritable bowel syndrome. Biopsychosoc. Med. 6, 20 (2012).
85. Goldstein, B. L., Klein, D. N. A review of selected candidate endophenotypes for depression. Clin. Psychol. Rev. 34, 417-427 (2014).
86. Ormel, J., et al. Neuroticism and common mental disorders: meaning and utility of a complex relationship. Clin. Psychol. Rev. 33, 686-697 (2013).
87. Muscatello, M. R., et al. Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome. World J. Gastroenterol. 20, 7570-7586 (2014).
88. Cuijpers, P., et al. Economic costs of neuroticism: a population-based study. Arch. Gen. Psychiatry 67, 1086-1093 (2010).
89. den Boeft, M., et al. The association between medically unexplained physical symptoms and health care use over two years and the influence of depressive and anxiety disorders and personality traits: a longitudinal study. BMC Health Serv. Res. 16, 100 (2016).
90. Hotopf, M., et al. Temporal relationships between physical symptoms and psychiatric disorder. Results from a national birth cohort. Br. J. Psychiatry 173, 255-261 (1998).
91. Neeleman, J., et al. Propensity to psychiatric and somatic ill-health: evidence from a birth cohort. Psychol. Med. 32, 793-803 (2002).
92. Kroenke, K., Spitzer, R. L. Gender differences in the reporting of physical and somatoform symptoms. Psychosom. Med. 60, 150-155 (1998).
93. Goodwin, R. D., Gotlib, I. H. Gender differences in depression: the role of personality factors. Psychiatry Res. 126, 135-142 (2004).
94. Koenig, H. G. Depression in hospitalized older patients with congestive heart failure. Gen. Hosp. Psychiatry 20, 29-43 (1998).
95. Strik, J. J., et al. One-year cumulative incidence of depression following myocardial infarction and impact on cardiac outcome. J. Psychosom. Res. 56, 59-66 (2004).
96. Leue, C., et al. Managing complex patients on a Medical Psychiatric Unit: an observational study of university hospital costs associated with medical service use, length of stay and psychiatric intervention. J. Psychosom. Res. 68, 295-302 (2010).
97. Fishbain, D. A., et al. Chronic pain-associated depression: antecedent or consequence of chronic pain? A review. Clin. J. Pain 13, 116-137 (1997).
98. Bair, M. J., et al. Anxiety but not social stressors predict 12-month depression and pain severity. Clin. J. Pain 29, 95-101 (2013).
99. Gerrits, M. M., et al. Pain and the onset of depressive and anxiety disorders. Pain 155, 53-59 (2014).
100. Kroenke, K., et al. Reciprocal relationship between pain and depression: a 12-month longitudinal analysis in primary care. J. Pain 12, 964-973 (2011).
101. Henningsen, P., et al. Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review. Psychosom. Med. 65, 528-533 (2003).
102. Koloski, N. A., et al. The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut 61, 1284-1290 (2012).
103. Pinto-Sanchez, M. I., et al. Anxiety and depression increase in a stepwise manner in parallel with multiple FGIDs and symptom severity and frequency. Am. J. Gastroenterol. 110, 1038-1048 (2015).
104. Lai, H., et al. Correlation between psychological stress levels and the severity of overactive bladder symptoms. BMC Urol. 15, 14 (2015).
105. Yunus, M. B. Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes. Semin. Arthritis Rheum. 36, 339-356 (2007).
106. Rovner, E. S., Wein, A. J. Incidence and prevalence of overactive bladder. Curr. Urol. Rep. 3, 434-438 (2002).
107. Temml, C., et al. Prevalence of the overactive bladder syndrome by applying the International Continence Society definition. Eur. Urol. 48, 622-627 (2005).
108. Kogan, M. I., et al. Epidemiology and impact of urinary incontinence, overactive bladder, and other lower urinary tract symptoms: results of the EPIC survey in Russia, Czech republic, and Turkey. Curr. Med. Res. Opin. 30, 2119-2130 (2014).
109. Moorthy, P., et al. Prevalence of overactive bladder in Asian men: an epidemiological survey. BJU Int. 93, 528-531 (2004).
110. Irwin, D. E., et al. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur. Urol. 50, 1306-1314 (2006).
111. Coyne, K. S., et al. National community prevalence of overactive bladder in the United States stratified by sex and age. Urology 77, 1081-1087 (2011).
112. Coyne, K. S., et al. The prevalence of lower urinary tract symptoms (LUTS) and overactive bladder (OAB) by racial/ethnic group and age: results from OAB-POLL. Neurourol. Urodyn. 32, 230-237 (2013).
113. Stewart, W. E., et al. Prevalence and burden of overactive bladder in the United States. World J. Urol. 20, 327-336 (2003).
114. Bedretdinova, D., et al. Prevalence of female urinary incontinence in the general population according to different definitions and study designs. Eur. Urol. 69, 256-264 (2016).
115. Milsom, I., et al. Global prevalence and economic burden of urgency urinary incontinence: a systematic review. Eur. Urol. 65, 79-95 (2014).
116. Serati, M., Ghezzi, F. The epidemiology of urinary incontinence: a case still open. Ann. Transl Med. 4, 123 (2016).
117. Kusek, J. W., Nyberg, L. M. The epidemiology of interstitial cystitis: is it time to expand our definition? Urology 57, S95-S99 (2001).
118. Berry, S. H., et al. Development, validation and testing of an epidemiological case definition of interstitial cystitis/painful bladder syndrome. J. Urol. 183, 1848-1852 (2010).
119. Berry, S. H., et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the united states. J. Urol. 186, 540-544 (2011).
120. Arora, H. C., Shoskes, D. A. The enigma of men with interstitial cystitis/bladder pain syndrome. Ann. Transl Med. 4, 668-676 (2015).
121. Clemens, J. Q., et al. Temporal ordering of interstitial cystitis/bladder pain syndrome and non-bladder conditions. Urology 80, 1227-1231 (2012).
122. Nickel, J. C., et al. Clinical and psychological parameters associated with pain pattern phenotypes in women with interstitial cystitis/bladder pain syndrome. J. Urol. 193, 138-144 (2015).
123. Lovell, R. M., Ford, A. C. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin. Gastroenterol. Hepatol. 10, 712-721 (2012).
124. Kessler, R. C., et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch. Gen. Psychiatry 62, 593-602 (2005).
125. Cole, J. A., et al. Migraine, fibromyalgia and depression among people with IBS: a prevalence study. BMC Gastroenterol. 6, 26 (2006).
126. Felde, G., et al. Anxiety and depression associated with urinary incontinence. A 10-year follow-up study from the Norwegian HUNT study (EPINCONT). Neurourol. Uroldyn. http://dx. doi. org/10. 1002/nau. 22921 (2015).
127. Nickel, J. C., et al. Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. J. Urol. 184, 1358-1363 (2010).
128. Nickel, J. C., et al. Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: a case control study. J. Urol. 184, 167-172 (2010).
129. Naliboff, B. D., et al. Widespread psychological difficulties in men and women with urologic chronic pelvic pain syndromes: case-control findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network. Urology 85, 1319-1327 (2015).
130. Clemens, J. Q., et al. Mental health diagnoses in patients with interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome: a case/control study. J. Urol. 180, 1378-1382 (2008).
131. Chung, K. H., et al. Bladder pain syndrome/interstitial cystitis is associated with anxiety disorder. Neurourol. Uroldyn. 33, 101-105 (2014).
132. Lutgendorf, S. K., et al. Stress and symptomatology in patients with interstitial cystitis: a laboratory stress model. J. Urol. 164, 1265-1269 (2000).
133. Drossman, D. A., et al. Severity in irritable bowel syndrome: a Rome foundation working team report. Am. J. Gastroenterol. 106, 1749-1759 (2011).
134. Clauss, J. A., et al. The nature of individual differences in inhibited temperament and risk for psychiatric disease: a review and meta-analysis. Prog. Neurobiol. 127-128, 23-45 (2015).
135. Iniguez, S. D., et al. Social defeat stress induces a depression-like phenotype in adolescent male c57b1/6 mice. Stress 17, 247-255 (2014).
136. Mahar, I., et al. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci. Biobehav. Rev. 38, 173-192 (2014).
137. Selye, H. A syndrome produced by diverse nocuous agents. J. Neuropsychiatry Clin. Neurosci. 10, 230-231 (1998).
138. McEwen, B. S. Physiology and neurobiology of stress and adaptation. Physiol. Rev. 87, 873-904 (2007).
139. Moloney, R. D., et al. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities. Front. Psychiatry 6, 15 (2015).
140. Charmandari, E., et al. Endocrinology of the stress response. Annu. Rev. Physiol. 67, 259-284 (2005).
141. McEwen, B. S. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. 886, 172-189 (2000).
142. Larauche, M., et al. Stress and visceral pain: from animal models to clinical therapies. Exp. Neurol. 233, 49-67 (2012).
143. O'Malley, D., et al. Do interactions between stress and immune responses lead to symptom exacerbation in irritable bowel syndrome? Brain Behav. Immun. 25, 1333-1341 (2011).
144. McEwen, B. S. Brain on stress: how the social environment gets under the skin. Proc. Natl Acad. Sci. USA 109 (Suppl. 2), 17180-17185 (2012).
145. Zhou, Q. Q., Verne, G. N. New insights into visceral hypersensitivity-clinical implications in IBS. Nat. Rev. Gatsroenterol. Hepatol. 8, 349-355 (2011).
146. Cheung, W. W., et al. Prevalence of overactive bladder, its under-diagnosis, and risk factors in a male urologic veterans population. Int. J. Med. Sci. 7, 391-394 (2010).
147. Geuze, E., et al. Altered pain processing in veterans with posttraumatic stress disorder. Arch. Gen. Psychiatry 64, 76-85 (2007).
148. Chiu, G. R., et al. Prevalence and overlap of childhood and adult physical, sexual, and emotional abuse: a descriptive analysis of results from the Boston Area Community Health (BACH) survey. Violence Vict. 28, 381-402 (2013).
149. Blanchard, E. B., et al. The role of stress in symptom exacerbation among IBS patients. J. Psychosom. Res. 64, 119-128 (2008).
150. Levy, R. L., et al. The relationship between daily life stress and gastrointestinal symptoms in women with irritable bowel syndrome. J. Behav. Med. 20, 177-193 (1997).
151. Jundt, K., et al. Physical and sexual abuse in patients with overactive bladder: is there an association? Int. Urogynecol. J. Pelvic Floor Dysfunct. 18, 449-453 (2007).
152. Mayson, B. E., Teichman, J. M. The relationship between sexual abuse and interstitial cystitis/painful bladder syndrome. Curr. Urol. Rep. 10, 441-447 (2009).
153. Klooker, T. K., et al. Exposure to severe wartime conditions in early life is associated with an increased risk of irritable bowel syndrome: a population-based cohort study. Am. J. Gastroenterol. 104, 2250-2256 (2009).
154. Chitkara, D. K., et al. Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review. Am. J. Gastroenterol. 103, 765-774 (2008).
155. van Tilburg, M. A., et al. Unexplained gastrointestinal symptoms after abuse in a prospective study of children at risk for abuse and neglect. Ann. Fam. Med. 8, 134-140 (2010).
156. O'Mahony, S. M., et al. Maternal separation as a model of brain-gut axis dysfunction. Psychopharmacology 214, 71-88 (2011).
157. Merrill, L., et al. Repeated variate stress in male rats induces increasing voiding frequency, somatic sensitivity, and urinary bladder nerve growth factor expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305, R147-R156 (2013).
158. Breyer, B. N., et al. Lower urinary tract dysfunction in male Iraq and Afghanistan war veterans: association with mental health disorders-a population-based cohort study. Urology 83, 312-319 (2014).
159. Nusslock, R., Miller, G. E. Early-life adversity and physical and emotional health across the lifespan: a neuroimmune network hypothesis. Biol. Psychiatry 80, 23-32 (2016).
160. Drossman, D. A. Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome? Am. J. Med. 107, 41S-50S (1999).
161. Surdea-Blaga, T., et al. Psychosocial determinants of irritable bowel syndrome. World J. Gastroenterol. 18, 616-626 (2012).
162. Costa, P. T., McCrae, R. R. NEO PI-R professional manual (Psychological Assessment Resources, 1992).
163. Hazlett-Stevens, H., et al. Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety. J. Psychosom. Res. 55, 501-505 (2003).
164. Farnam, A., et al. Personality factors and profiles in variants of irritable bowel syndrome. World J. Gastroenterol. 13, 6414-6418 (2007).
165. van Tilburg, M. A., et al. Which psychological factors exacerbate irritable bowel syndrome? Development of a comprehensive model. J. Psychosom. Res. 74, 486-492 (2013).
166. Sullivan, M. J., et al. Theoretical perspectives on the relation between catastrophizing and pain. Clin. J. Pain 17, 52-64 (2001).
167. Lackner, J. M., et al. Depression and abdominal pain in IBS patients: the mediating role of catastrophizing. Psychosom. Med. 66, 435-441 (2004).
168. Lackner, J. M., et al. Patient reported outcomes for irritable bowel syndrome are associated with patients' severity ratings of gastrointestinal symptoms and psychological factors. Clin. Gastroenterol. Hepatol. 9, 957-964 (2011).
169. Cortes, E., et al. The psychology of LUTS: ICI-RS 2011. Neurourol. Urodyn. 31, 340-343 (2012).
170. Davydov, D. M., et al. Resilience and mental health. Clin. Psychol. Rev. 30, 479-495 (2010).
171. Lutha, S. S., Cicchetti, D. The construct of resilience: implications for interventions and social policies. Dev. Psychopathol. 12, 857-885 (2000).
172. Daskalakis, N. P., et al. The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology 38, 1858-1873 (2013).
173. Daskalakis, N. P., et al. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model. Physiol. Behav. 106, 707-721 (2012).
174. Sousa, N. The dynamics of the stress neuromatrix. Mol. Psychiatry 21, 302-312 (2016).
175. Spiller, R. Postinfectious functional dyspepsia and postinfectious irritable bowel syndrome: different symptoms but similar risk factors. Gastroenterology 138, 1660-1663 (2010).
176. Herzog, A. R., Fultz, N. H. Prevalence and incidence of urinary incontinence in community-dwelling populations. J. Am. Geriatr. Soc. 38, 273-281 (1990).
177. Brown, J. S., et al. Prevalence of urinary incontinence and associated risk factors in postmenopausal women. Heart and Estrogen/Progestin Replacement Study (HERS) Research Group. Obstet. Gynecol. 94, 66-70 (1999).
178. Moore, E. E., et al. Urinary incontinence and urinary tract infection: temporal relationships in postmenopausal women. Obstet. Gynecol. 111, 317-323 (2008).
179. Stanford, E., McMurphy, C. There is a low incidence of recurrent bacteriuria in painful bladder syndrome/interstitial cystitis patients followed longitudinally. Int. Urogynecol. J. Pelvic Floor Dysfunct. 18, 551-554 (2007).
180. Walsh, C. A., Moore, K. H. Overactive bladder in women: does low-count bacteriuria matter? A review. Neurourol. Urodyn. 30, 32-37 (2011).
181. Walsh, C. A., et al. Prevalence of "low-count" bacteriuria in female urinary incontinence versus continent female controls: a cross-sectional study. Int. Urogynecol. J. 22, 1267-1272 (2011).
182. Sorrentino, F., et al. Associations between individual lower urinary tract symptoms and bacteriuria in random urine samples in women. Neurourol. Urodyn. 34, 429-433 (2015).
183. Kashriya, R., et al. The inadequacy of urinary dipstick and microscopy as surrogate markers of urinary tract infection in urological outpatients with lower urinary tract symptoms without acute frequency and dysuria. J. Urol. 183, 1843-1847 (2010).
184. Hessdoerfer, E., et al. Is a dipstick test sufficient to exclude urinary tract infection in women with overactive bladder? Int. Urogynecol. J. 22, 229-232 (2011).
185. Wolfe, A. J., et al. Evidence of uncultivated bacteria in the adult female bladder. J. Clin. Microbiol. 50, 1376-1383 (2012).
186. Kashriya, R., et al. Spectrum of bacterial colonization with urothelial cells from patients with chronic lower urinary tract symptoms. J. Clin. Microbiol. 51, 2054-2062 (2013).
187. Hannan, T. J., et al. Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic E. coli bladder infection. FEMS Microbiol. Rev. 36, 616-648 (2012).
188. Nicolle, L. E. Asymptomatic bacteriuria. Curr. Opin. Infect. Dis. 27, 90-96 (2014).
189. Moore, K. H., Malykhina, A. P. What is the role of covert infection in detrusor overactivity, and other LUTD? ICI-RS 2013. Neurourol. Urodyn. 33, 606-610 (2014).
190. Mabbett, A. N., et al. Virulence properties of asymptomatic bacteriuria Escherichia coli. Int. J. Med. Microbiol. 299, 53-63 (2009).
191. Ragnarsdottir, B., et al. Genetics of innate immunity and UTI susceptibility. Nat. Rev. Urol. 8, 449-468 (2011).
192. Peters, K. M., et al. Childhood symptoms and events in women with interstitial cystitis/painful bladder syndrome. Urology 73, 258-262 (2009).
193. Rosen, J. M., Klumpp, D. J. Mechanisms of pain from urinary tract infection. Int. J. Urol. 21 (Suppl. 1), 26-32 (2014).
194. McLellan, L. K., Hunstad, D. A. Urinary tract infection: pathogenesis and outlook. Trends Mol. Med. http://dx. doi. org/10. 1016/j. mol. med. 2016. 09003 (2016).
195. Lüthje, P., Brauner, A. Virulence factors of uropathogenic E. coli and their interaction with the host. Adv. Microb. Physiol. 65, 337-372 (2014).
196. Mulvey, M. A., Schilling, J. D., Martinez, J. J., Hultgren, S. J. Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses. Proc. Natl Acad. Sci. USA 97, 8829-8835 (2000).
197. Billips, B. K., et al. Molecular basis of uropathogenic Escherichia coli evasion of the innate immune response in the bladder. Infect. Immun. 76, 3891-3900 (2008).
198. Ragnarsdottir, B., Svanborg, C. Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: host-pathogen interaction in urinary tract infections. Pediatr. Nephrol. 27, 2017-2029 (2012).
199. Woolf, C. J., Salter, M. W. Neuronal plasticity: increasing the gain in pain. Science 288, 1765-1769 (2000).
200. Rudick, C. N., et al. O-antigen modulates infection-induced pain states. PLoS ONE 7, e1273 (2012).
201. Collins, S. M. A role for the gut microbiota in IBS. Nat. Rev. Gastroenterol. Hepatol. 11, 497-505 (2014).
202. Proctor, L. M. The human microbiome project in 2011 and beyond. Cell Host Microbe 10, 287-291 (2011).
203. Siddiqui, H., et al. Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons. BMC Micobiol. 11, 244 (2011).
204. Lewis, D. A., et al. The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults. Front. Cell. Infect. Microbiol. 3, 41 (2013).
205. Pearce, M. M., et al. The female urinary microbiome: a comparison of women with and without urgency urinary incontinence. mBio 5, e01283-14 (2014).
206. Siddiqui, H., et al. Alterations of microbiota in urine from women with interstitial cystitis. BMC Microbiol. 12, 205 (2012).
207. Stapleton, A. E. Urinary tract infection pathogenesis: host factors. Infect. Dis. Clin. North. Am. 28, 149-159 (2014).
208. Ferry, S. A., et al. The natural course of lower uncomplicated urinary tract infection in women illustrated by a randomized placebo controlled study. Scand. J. Infect. Dis. 36, 296-301 (2004).
209. Reid, G., et al. Microbiota restauration: natural and supplemented recovery of human microbial communities. Nat. Rev. Microbiol. 9, 27-38 (2011).
210. Ott, S. J., et al. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 53, 685-693 (2004).
211. Turnbaugh, P. J. A core gut microbiome in obese and lean twins. Nature 457, 480-484 (2009).
212. Cosseau, C., et al. The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect. Immun. 76, 4163-4175 (2008).
213. Naseribafrouei, A., et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol. Motil. 26, 1155-1162 (2014).
214. Kaplan, S. A., et al. Systematic review of the relationship between bladder and bowel function: implications for patient management. Int. J. Clin. Pract. 67, 205-216 (2013).
215. Janssens, K. A., et al. Mood and anxiety disorders in chronic fatigue syndrome, fibromyalgia, and irritable bowel syndrome: results from the LifeLines cohort study. Psychosom. Med. 77, 449-457 (2015).
216. Thijssen, A. Y., et al. Dysfunctional cognitions, anxiety and depression in irritable bowel syndrome. J. Clin. Gastroenterol. 44, e236-e241 (2010).
217. Kruimel, J., et al. Integrated medical-psychiatric outpatient care in functional gastrointestinal disorders improves outcome: a pilot study. Eur. J. Gastroenterol. Hepatol. 27, 721-727 (2015).
218. Marshall, J. K., et al. Eight year prognosis of post infectious irritable bowel syndrome following waterborne bacterial dysentery. Gut 59, 605-611 (2010).
219. Berghmans, B., et al. Prevalence and triage of first-contact complaints on pelvic floor dysfunctions in female patients at a Pelvic Care Centre. Neurourol. Urodyn. 35, 503-508 (2015).
220. Berghmans, B., et al. Prevalence and triage of first-contact complaints on pelvic floor dysfunctions in male patients referred to a Pelvic Care Centre. Neurourol. Urodyn. 35, 487-491 (2015).
221. Filipetto, F. A., et al. The patient perspective on overactive bladder: a mixed-methods needs assessment. BMC Fam. Pract. 15, 96 (2014).
222. Bosch, P. C., Bosch, D. C. Treating interstitial cystitis/bladder pain syndrome as a chronic disease. Rev. Urol. 16, 83-87 (2014).
223. Sharpe, M., et al. Is co-morbid depression adequately treated in patients repeatedly referred to specialist medical services with symptoms of a medical condition? J. Psychosom. Res. 72, 419-421 (2012).
224. Shoskes, D. A., et al. Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT. Urology 75, 1249-1253 (2010).
225. Kartha, G. K., et al. Clinical phenotyping of urological pain patients. Curr. Opin. Urol. 23, 560-564 (2013).
226. Clemens, J. Q., et al. The MAPP research network: a novel study of urologic pelvic pain syndromes. BMC Urol. 14, 57 (2014).
227. Mujagic, Z., et al. Systematic review: instruments to assess abdominal pain in irritable bowel syndrome. Aliment. Pharmacol. Ther. 42, 1064-1081 (2015).
228. Mujagic, Z., et al. The Experience Sampling Method-a new digital tool for momentary symptom assessment in IBS: an exploratory study. Neurogastroenterol. Motil. 27, 1295-1302 (2015).
229. Myin-Germeys, I. Experience sampling research in psychopathology: opening the black box of daily life. Psychol. Med. 39, 1533-1547 (2009).
230. Konnopka, A., et al. Economics of medically unexplained symptoms: a systematic review of the literature. Psychother. Psychosom. 81, 265-275 (2012).
231. Archer, J., et al. Collaborative care for depression and anxiety problems. Cochrane Database Syst. Rev. 10, CD006525 (2012).
232. Tully, P. J., Baumaeister, H. Collaborative care for comorbid depression and coronary heart disease: a systematic review and meta-analysis of randomized controlled trials. BMJ Open 5, e009128 (2015).
233. Huffman, J. C., et al. Essential articles on collaborative care models for the treatment of psychiatric disorders in medical settings: a publication by the academy of psychosomatic medicine research and evidence-based practice committee. Psychosomatics 55, 109-122 (2014).
234. Leue, C., et al. Observational evidence that urbanisation and neighbourhood deprivation are associated with escalation in chronic pharmacological pain treatment: a longitudinal population-based study in the Netherlands. BMJ Open 2, e000731 (2012).
235. Balachandran, A., et al. Management of female urinary incontinence: a survey of urogynaecologists' view on the NICE guideline. J. Obstet. Gynaecol. 9, 1-5 (2015).
236. Warren, J. W., Clauw, D. J. Functional somatic syndromes: sensitivities and specificities of self-reports of physicians' diagnosis. Psychosom. Med. 74, 891-895 (2012).
237. Gawronski, K. A., et al. Potentially traumatic events and serious life stressors are prospectively associated with frequency of doctor visits and overnight hospital visits. J. Psychosom. Res. 77, 90-96 (2014).
238. Pierce, A. N., et al. Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress. Brain Res. 1639, 58-73 (2016).
239. Mayer, E. A., et al. Towards a systems view of IBS. Nat. Rev. Gastroenterol. Hepatol. 12, 592-605 (2015).
240. Teicher, M. H., et al. The effects of childhood maltreatment on brain structure, function and connectivity. Nat. Rev. Neurosci. 17, 652-666 (2016).