메뉴 건너뛰기




Volumn 11, Issue 9, 2016, Pages 1681-1692

Generation of kidney organoids from human pluripotent stem cells

Author keywords

[No Author keywords available]

Indexed keywords

CUBILIN; MEGALIN;

EID: 85001690132     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2016.098     Document Type: Article
Times cited : (237)

References (51)
  • 1
    • 34447528757 scopus 로고    scopus 로고
    • New cell lines from mouse epiblast share defining features with human embryonic stem cells
    • Tesar, P.J. et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448, 196-199 (2007).
    • (2007) Nature , vol.448 , pp. 196-199
    • Tesar, P.J.1
  • 2
    • 84896696490 scopus 로고    scopus 로고
    • Recreating kidney progenitors from pluripotent cells
    • Takasato, M., Maier, B. & Little, M.H. Recreating kidney progenitors from pluripotent cells. Pediatr. Nephrol. 29, 543-552 (2014).
    • (2014) Pediatr. Nephrol. , vol.29 , pp. 543-552
    • Takasato, M.1    Maier, B.2    Little, M.H.3
  • 3
    • 39349097787 scopus 로고    scopus 로고
    • Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors
    • Davis, R.P. et al. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. Blood 111, 1876-1884 (2008).
    • (2008) Blood , vol.111 , pp. 1876-1884
    • Davis, R.P.1
  • 4
    • 44349175948 scopus 로고    scopus 로고
    • Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    • Yang, L. et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453, 524-528 (2008).
    • (2008) Nature , vol.453 , pp. 524-528
    • Yang, L.1
  • 5
    • 34248363665 scopus 로고    scopus 로고
    • A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells
    • Wang, D., Haviland, D.L., Burns, A.R., Zsigmond, E. & Wetsel, R.A. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 104, 4449-4454 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 4449-4454
    • Wang, D.1    Haviland, D.L.2    Burns, A.R.3    Zsigmond, E.4    Wetsel, R.A.5
  • 6
    • 84910673362 scopus 로고    scopus 로고
    • Generation of functional human pancreatic β cells in vitro
    • Pagliuca, F.W. et al. Generation of functional human pancreatic β cells in vitro. Cell 159, 428-439 (2014).
    • (2014) Cell , vol.159 , pp. 428-439
    • Pagliuca, F.W.1
  • 7
    • 80955137949 scopus 로고    scopus 로고
    • Generating human intestinal tissue from pluripotent stem cells in vitro
    • McCracken, K.W., Howell, J.C., Wells, J.M. & Spence, J.R. Generating human intestinal tissue from pluripotent stem cells in vitro. Nat. Protoc. 6, 1920-1928 (2011).
    • (2011) Nat. Protoc. , vol.6 , pp. 1920-1928
    • McCracken, K.W.1    Howell, J.C.2    Wells, J.M.3    Spence, J.R.4
  • 8
    • 67649382407 scopus 로고    scopus 로고
    • Differentiation of neuroepithelia from human embryonic stem cells
    • Xia, X. & Zhang, S. Differentiation of neuroepithelia from human embryonic stem cells. Methods Mol. Biol. 549, 51-58 (2009).
    • (2009) Methods Mol. Biol. , vol.549 , pp. 51-58
    • Xia, X.1    Zhang, S.2
  • 9
    • 84891298711 scopus 로고    scopus 로고
    • Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
    • Takasato, M. et al. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat. Cell Biol. 16, 118-126 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , pp. 118-126
    • Takasato, M.1
  • 10
    • 84904396621 scopus 로고    scopus 로고
    • Organogenesis in a dish: Modeling development and disease using organoid technologies
    • Lancaster, M.A. & Knoblich, J.A. Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345, 1247125 (2014).
    • (2014) Science , vol.345 , pp. 1247125
    • Lancaster, M.A.1    Knoblich, J.A.2
  • 11
    • 84884414984 scopus 로고    scopus 로고
    • Cerebral organoids model human brain development and microcephaly
    • Lancaster, M.A. et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373-379 (2013).
    • (2013) Nature , vol.501 , pp. 373-379
    • Lancaster, M.A.1
  • 12
    • 84862526635 scopus 로고    scopus 로고
    • Self-formation of optic cups and storable stratified neural retina from human ESCs
    • Nakano, T. et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 10, 771-785 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 771-785
    • Nakano, T.1
  • 13
    • 84918561297 scopus 로고    scopus 로고
    • Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
    • McCracken, K.W. et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516, 400-404 (2014).
    • (2014) Nature , vol.516 , pp. 400-404
    • McCracken, K.W.1
  • 14
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence, J.R. et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470, 105-109 (2011).
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1
  • 15
    • 84881184980 scopus 로고    scopus 로고
    • Vascularized and functional human liver from an iPSC-derived organ bud transplant
    • Takebe, T. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481-484 (2013).
    • (2013) Nature , vol.499 , pp. 481-484
    • Takebe, T.1
  • 16
    • 84945283561 scopus 로고    scopus 로고
    • Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
    • Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564-568 (2015).
    • (2015) Nature , vol.526 , pp. 564-568
    • Takasato, M.1
  • 17
    • 85031880839 scopus 로고    scopus 로고
    • Generation of kidney organoids from human pluripotent stem cells
    • Takasato, M., Er, P.X., Chiu, H.S. & Little, M.H. Generation of kidney organoids from human pluripotent stem cells. Protoc. Exch. doi:10.1038/protex.2015.087 (2015).
    • (2015) Protoc. Exch.
    • Takasato, M.1    Er, P.X.2    Chiu, H.S.3    Little, M.H.4
  • 18
    • 33746690392 scopus 로고    scopus 로고
    • Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression
    • Iimura, T. & Pourquié, O. Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression. Nature 442, 568-571 (2006).
    • (2006) Nature , vol.442 , pp. 568-571
    • Iimura, T.1    Pourquié, O.2
  • 19
    • 47349122452 scopus 로고    scopus 로고
    • The migration of paraxial and lateral plate mesoderm cells emerging from the late primitive streak is controlled by different Wnt signals
    • Sweetman, D., Wagstaff, L., Cooper, O., Weijer, C. & Münsterberg, A. The migration of paraxial and lateral plate mesoderm cells emerging from the late primitive streak is controlled by different Wnt signals. BMC Dev. Biol. 8, 63 (2008).
    • (2008) BMC Dev. Biol. , vol.8 , pp. 63
    • Sweetman, D.1    Wagstaff, L.2    Cooper, O.3    Weijer, C.4    Münsterberg, A.5
  • 21
    • 65949113845 scopus 로고    scopus 로고
    • Using mouse models to understand normal and abnormal urogenital tract development
    • Mendelsohn, C. Using mouse models to understand normal and abnormal urogenital tract development. Organogenesis 5, 306-314 (2009).
    • (2009) Organogenesis , vol.5 , pp. 306-314
    • Mendelsohn, C.1
  • 22
    • 48149095359 scopus 로고    scopus 로고
    • Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
    • Kobayashi, A. et al. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3, 169-181 (2008).
    • (2008) Cell Stem Cell , vol.3 , pp. 169-181
    • Kobayashi, A.1
  • 23
    • 55749097944 scopus 로고    scopus 로고
    • Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney
    • Mugford, J.W., Sipilä, P., McMahon, J.A. & McMahon, A.P. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev. Biol. 324, 88-98 (2008).
    • (2008) Dev. Biol. , vol.324 , pp. 88-98
    • Mugford, J.W.1    Sipilä, P.2    McMahon, J.A.3    McMahon, A.P.4
  • 24
    • 33750936779 scopus 로고    scopus 로고
    • Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
    • Gadue, P., Huber, T.L., Paddison, P.J. & Keller, G.M. Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc. Natl. Acad. Sci. 103, 16806-16811 (2006).
    • (2006) Proc. Natl. Acad. Sci. , vol.103 , pp. 16806-16811
    • Gadue, P.1    Huber, T.L.2    Paddison, P.J.3    Keller, G.M.4
  • 25
    • 34247226529 scopus 로고    scopus 로고
    • Gene function in mouse embryogenesis: Get set for gastrulation
    • Tam, P.P.L. & Loebel, D.A.F. Gene function in mouse embryogenesis: get set for gastrulation. Nat. Rev. Genet. 8, 368-381 (2007).
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 368-381
    • Tam, P.P.L.1    Loebel, D.A.F.2
  • 26
    • 53349091628 scopus 로고    scopus 로고
    • Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/β-catenin, Activin/Nodal and BMP signaling
    • Sumi, T., Tsuneyoshi, N., Nakatsuji, N. & Suemori, H. Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/β-catenin, Activin/Nodal and BMP signaling. Development 135, 2969-2979 (2008).
    • (2008) Development , vol.135 , pp. 2969-2979
    • Sumi, T.1    Tsuneyoshi, N.2    Nakatsuji, N.3    Suemori, H.4
  • 27
    • 28244481924 scopus 로고    scopus 로고
    • Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner
    • James, R.G. & Schultheiss, T.M. Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner. Dev. Biol. 288, 113-125 (2005).
    • (2005) Dev. Biol. , vol.288 , pp. 113-125
    • James, R.G.1    Schultheiss, T.M.2
  • 28
    • 0032857909 scopus 로고    scopus 로고
    • Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene
    • Colvin, J.S., Feldman, B., Nadeau, J.H., Goldfarb, M. & Ornitz, D.M. Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Dev. Dyn. 216, 72-88 (1999).
    • (1999) Dev. Dyn. , vol.216 , pp. 72-88
    • Colvin, J.S.1    Feldman, B.2    Nadeau, J.H.3    Goldfarb, M.4    Ornitz, D.M.5
  • 29
    • 84922124896 scopus 로고    scopus 로고
    • Dissociation of embryonic kidney followed by re-aggregation as a method for chimeric analysis
    • Davies, J.A., Unbekandt, M., Ineson, J., Lusis, M. & Little, M.H. Dissociation of embryonic kidney followed by re-aggregation as a method for chimeric analysis. Methods Mol. Biol. 886, 135-146 (2012).
    • (2012) Methods Mol. Biol. , vol.886 , pp. 135-146
    • Davies, J.A.1    Unbekandt, M.2    Ineson, J.3    Lusis, M.4    Little, M.H.5
  • 30
    • 84891281146 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells
    • Xia, Y. et al. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat. Cell Biol. 15, 1507-1515 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1507-1515
    • Xia, Y.1
  • 31
    • 84906088790 scopus 로고    scopus 로고
    • Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers
    • Lam, A.Q. et al. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J. Am. Soc. Nephrol. 25, 1211-1225 (2014).
    • (2014) J. Am. Soc. Nephrol. , vol.25 , pp. 1211-1225
    • Lam, A.Q.1
  • 32
    • 84899635769 scopus 로고    scopus 로고
    • Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system
    • Kang, M. & Han, Y. Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system. PLoS One 9, e94888 (2014).
    • (2014) PLoS One , vol.9 , pp. e94888
    • Kang, M.1    Han, Y.2
  • 33
    • 84940042150 scopus 로고    scopus 로고
    • Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice
    • Toyohara, T. et al. Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice. Stem Cells Transl. Med. 4, 980-992 (2015).
    • (2015) Stem Cells Transl. Med. , vol.4 , pp. 980-992
    • Toyohara, T.1
  • 34
    • 84891737192 scopus 로고    scopus 로고
    • Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells
    • Taguchi, A. et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53-67 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 53-67
    • Taguchi, A.1
  • 35
    • 85016960125 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived podocytes mature into vascularized glomeruli upon experimental transplantation
    • Sharmin, S. et al. Human induced pluripotent stem cell-derived podocytes mature into vascularized glomeruli upon experimental transplantation. J. Am. Soc. Nephrol. 27, 1778-1791 (2016).
    • (2016) J. Am. Soc. Nephrol. , vol.27 , pp. 1778-1791
    • Sharmin, S.1
  • 36
    • 84947241512 scopus 로고    scopus 로고
    • Nephron organoids derived from human pluripotent stem cells model kidney development and injury
    • Morizane, R. et al. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat. Biotechnol. 33, 1193-1200 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 1193-1200
    • Morizane, R.1
  • 37
    • 84945246096 scopus 로고    scopus 로고
    • Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
    • Freedman, B.S. et al. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat. Commun. 6, 8715 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8715
    • Freedman, B.S.1
  • 38
    • 84929875000 scopus 로고    scopus 로고
    • The origin of the mammalian kidney: Implications for recreating the kidney in vitro
    • Takasato, M. & Little, M.H. The origin of the mammalian kidney: implications for recreating the kidney in vitro. Development 142, 1937-1947 (2015).
    • (2015) Development , vol.142 , pp. 1937-1947
    • Takasato, M.1    Little, M.H.2
  • 39
    • 28244486151 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2
    • Ciarimboli, G. et al. Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am. J. Pathol. 167, 1477-1484 (2005).
    • (2005) Am. J. Pathol. , vol.167 , pp. 1477-1484
    • Ciarimboli, G.1
  • 40
    • 0037195066 scopus 로고    scopus 로고
    • Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
    • Ishida, S., Lee, J., Thiele, D.J. & Herskowitz, I. Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc. Natl. Acad. Sci. USA 99, 14298-14302 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14298-14302
    • Ishida, S.1    Lee, J.2    Thiele, D.J.3    Herskowitz, I.4
  • 41
    • 77950462459 scopus 로고    scopus 로고
    • Genetic kidney diseases
    • Hildebrandt, F. Genetic kidney diseases. Lancet 375, 1287-1295 (2010).
    • (2010) Lancet , vol.375 , pp. 1287-1295
    • Hildebrandt, F.1
  • 42
    • 2642621586 scopus 로고    scopus 로고
    • Differential expression and function of cadherin-6 during renal epithelium development
    • Cho, E.A. et al. Differential expression and function of cadherin-6 during renal epithelium development. Development 125, 803-812 (1998).
    • (1998) Development , vol.125 , pp. 803-812
    • Cho, E.A.1
  • 43
    • 84926227818 scopus 로고    scopus 로고
    • Cell-cell interactions driving kidney morphogenesis
    • Combes, A.N., Davies, J.A. & Little, M.H. Cell-cell interactions driving kidney morphogenesis. Curr. Top. Dev. Biol. 112, 467-508 (2015).
    • (2015) Curr. Top. Dev. Biol. , vol.112 , pp. 467-508
    • Combes, A.N.1    Davies, J.A.2    Little, M.H.3
  • 44
    • 57349118536 scopus 로고    scopus 로고
    • HTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics
    • Wieser, M. et al. hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics. Am. J. Physiol. Renal Physiol. 295, F1365-F1375 (2008).
    • (2008) Am. J. Physiol. Renal Physiol. , vol.295 , pp. F1365-F1375
    • Wieser, M.1
  • 45
    • 0027223023 scopus 로고
    • Stage-and segment-specific expression of cell-adhesion molecules N-CAM, A-CAM, and L-CAM in the kidney
    • Nouwen, E.J., Dauwe, S., van der Biest, I. & De Broe, M.E. Stage-and segment-specific expression of cell-adhesion molecules N-CAM, A-CAM, and L-CAM in the kidney. Kidney Int. 44, 147-158 (1993).
    • (1993) Kidney Int. , vol.44 , pp. 147-158
    • Nouwen, E.J.1    Dauwe, S.2    Van Der Biest, I.3    De Broe, M.E.4
  • 46
    • 84874913500 scopus 로고    scopus 로고
    • Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology
    • Briggs, J.A. et al. Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology. Stem Cells 31, 467-78 (2013).
    • (2013) Stem Cells , vol.31 , pp. 467-478
    • Briggs, J.A.1
  • 47
    • 84921318905 scopus 로고    scopus 로고
    • Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis
    • Xu, J. et al. Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis. Dev. Cell 31, 434-447 (2014).
    • (2014) Dev. Cell , vol.31 , pp. 434-447
    • Xu, J.1
  • 48
    • 46049114472 scopus 로고    scopus 로고
    • Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo
    • Mugford, J.W., Sipilä, P., Kobayashi, A., Behringer, R.R. & McMahon, A.P. Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev. Biol. 319, 396-405 (2008).
    • (2008) Dev. Biol. , vol.319 , pp. 396-405
    • Mugford, J.W.1    Sipilä, P.2    Kobayashi, A.3    Behringer, R.R.4    McMahon, A.P.5
  • 49
    • 40449141341 scopus 로고    scopus 로고
    • Marked differences in differentiation propensity among human embryonic stem cell lines
    • Osafune, K. et al. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat. Biotechnol. 26, 313-315 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 313-315
    • Osafune, K.1
  • 50
    • 43149101280 scopus 로고    scopus 로고
    • A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies
    • Ng, E.S., Davis, R., Stanley, E.G. & Elefanty, A.G. A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies. Nat. Protoc. 3, 768-776 (2008).
    • (2008) Nat. Protoc. , vol.3 , pp. 768-776
    • Ng, E.S.1    Davis, R.2    Stanley, E.G.3    Elefanty, A.G.4
  • 51
    • 84883741356 scopus 로고    scopus 로고
    • Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
    • Das, A. et al. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat. Cell Biol. 15, 1035-1044 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1035-1044
    • Das, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.