Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice

Stem Cells Translational Medicine

Volumn 4, Issue 9, 2015, Pages 980-992

  Toyohara, Takafumi ^a   Mae, Shin Ichi ^a   Sueta, Shin Ichi ^a   Inoue, Tatsuyuki ^a   Yamagishi, Yukiko ^b   Kawamoto, Tatsuya ^b   Kasahara, Tomoko ^a   Hoshina, Azusa ^a   Toyoda, Taro ^a   Tanaka, Hiromi ^a   Araoka, Toshikazu ^a   Sato Otsubo, Aiko ^c   Takahashi, Kazutoshi ^a   Sato, Yasunori ^d   Yamaji, Noboru ^b   Ogawa, Seishi ^c   Yamanaka, Shinya ^a,e   Osafune, Kenji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

Acute kidney injury; Cell and tissue based therapy; Induced pluripotent stem cells; Kidney; Nephrons; Renal progenitors; SIX2 protein

Indexed keywords

ALPHA INTEGRIN; CREATININE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LECTIN; NOGGIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXA10; TRANSCRIPTION FACTOR HOXA11; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR TBX6; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; WT1 PROTEIN; BIOLOGICAL MARKER; HOMEODOMAIN PROTEIN; NERVE PROTEIN; OSR1 PROTEIN, HUMAN; SIX2 PROTEIN, HUMAN;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA MODIFICATION; FIBROBLAST; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KARYOTYPING; KIDNEY DYSFUNCTION; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; STEM CELL CULTURE; STEM CELL TRANSPLANTATION; TISSUE REGENERATION; ACUTE KIDNEY INJURY; ANIMAL; BIOLOGICAL THERAPY; BLOOD; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; FIBROSIS; GENE EXPRESSION; GENETICS; INJURIES; KIDNEY TUBULE; MALE; METABOLISM; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; REPERFUSION INJURY; SCID MOUSE; STEM CELL; TRANSPLANTATION; UREA NITROGEN BLOOD LEVEL; UROTHELIUM; XENOGRAFT;

MUS;

ACUTE KIDNEY INJURY; ANIMALS; BIOMARKERS; BLOOD UREA NITROGEN; CELL DIFFERENTIATION; CELL- AND TISSUE-BASED THERAPY; CELLS, CULTURED; CREATININE; EPITHELIAL CELLS; FIBROSIS; GENE EXPRESSION; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KIDNEY TUBULES; MALE; MICE; MICE, SCID; NECROSIS; NERVE TISSUE PROTEINS; REPERFUSION INJURY; STEM CELLS; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; UROTHELIUM;

EID: 84940042150     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0219     Document Type: Article

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