The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity

Toxicology and Applied Pharmacology

Volumn 314, Issue , 2017, Pages 98-108

  Yin, Li ^a   Dai, Yanlin ^a,b   Cui, Zhihong ^a   Jiang, Xiao ^a   Liu, Wenbin ^a   Han, Fei ^a   Lin, Ao ^a   Cao, Jia ^a   Liu, Jinyi ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Chuxiong Medical College   (China)

Author keywords

Bisphenol A; Endoplasmic reticulum stress; Male reproductive toxicity; PERK EIF2 chop pathway

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; INITIATION FACTOR 2ALPHA; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; BENZHYDRYL DERIVATIVE; DDIT3 PROTEIN, MOUSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2; PERK KINASE; PHENOL DERIVATIVE; PROTEIN KINASE R;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SPERMATOCYTE; SPERMATOZOON; ANIMAL; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; MALE INFERTILITY; METABOLISM; TESTIS;

ANIMALS; APOPTOSIS; BENZHYDRYL COMPOUNDS; CELL PROLIFERATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; INFERTILITY, MALE; MALE; MICE; MITOCHONDRIA; PHENOLS; REACTIVE OXYGEN SPECIES; TESTIS; TRANSCRIPTION FACTOR CHOP;

EID: 85000608307     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2016.11.013     Document Type: Article

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