Mitochondria-derived reactive oxygen species play an important role in doxorubicin-induced platelet apoptosis

International Journal of Molecular Sciences

Volumn 16, Issue 5, 2015, Pages 11087-11100

  Wang, Zhicheng ^a   Wang, Jie ^a   Xie, Rufeng ^b   Liu, Ruilai ^a   Lu, Yuan ^a  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Blood Center   (China)

Author keywords

Apoptosis; Doxorubicin; Mitochondria; Platelets; Reactive oxygen species

Indexed keywords

ADENOSINE DIPHOSPHATE; CARDIOLIPIN; CASPASE 3; CYTOCHROME C; DOXORUBICIN; GLYCOPROTEIN IB ALPHA; MALONALDEHYDE; MITO TEMPO; PHOSPHATIDYLSERINE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SCAVENGER; THROMBIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; ANTINEOPLASTIC ANTIBIOTIC; THROMBIN RECEPTOR;

ADULT; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DEPOLARIZATION; FEMALE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LIPID PEROXIDATION; MALE; MIDDLE AGED; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PLATELET-RICH PLASMA CELL; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA; WESTERN BLOTTING; CYTOLOGY; DRUG EFFECTS; METABOLISM; OXIDATIVE STRESS; THROMBOCYTE;

VASCONCELLEA CANDICANS;

ADULT; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD PLATELETS; CARDIOLIPINS; CASPASE 3; CYTOCHROMES C; DOXORUBICIN; FEMALE; HUMANS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; REACTIVE OXYGEN SPECIES; VON WILLEBRAND FACTOR;

EID: 84929379635     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160511087     Document Type: Article

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