Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress

Neurochemistry International

Volumn 56, Issue 2, 2010, Pages 352-356

  Matsuzaki, Shinsuke ^a,b   Hiratsuka, Toru ^a   Kuwahara, Ryusuke ^a   Katayama, Taiichi ^b   Tohyama, Masaya ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Ca homeostasis; Calpain: EGTA; Caspase 4; Cell deat

Indexed keywords

CALPAIN; CASPASE 4; EGTAZIC ACID;

ARTICLE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NERVE CELL NECROSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

CALCIUM; CALPAIN; CASPASES, INITIATOR; CELL LINE, TUMOR; CHELATING AGENTS; EGTAZIC ACID; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITORS; HOMEOSTASIS; HUMANS; HYDROLYSIS; THAPSIGARGIN; TUNICAMYCIN;

EID: 77149146499     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.11.007     Document Type: Article

References (17)

1. Atkin J.D., Farg M.A., Turner B.J., Tomas D., Lysaght J.A., Nunan J., Rembach A., Nagley P., Beart P.M., Cheema S.S., Horne M.K. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. J. Biol. Chem. 2006, 281:30152-30165.
2. Bando Y., Katayama T., Kasai K., Taniguchi M., Tamatani M., Tohyama M. GRP94 (94kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury. Eur. J. Neurosci. 2003, 18:829-840.
3. Chan S.L., Mattson M.P. Caspase and calpain substrates: roles in synaptic plasticity and cell death. J. Neurosci. Res. 1999, 58:167-190.
4. Fischer H., Koenig U., Eckhart L., Tschachler E. Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 2002, 293:722-726.
5. Hitomi J., Katayama T., Eguchi Y., Kudo T., Taniguchi M., Koyama Y., Manabe T., Yamagishi S., Bando Y., Imaizumi K., Tsujimoto Y., Tohyama M. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J. Cell Biol. 2004, 165:347-356.
6. Katayama T., Imaizumi K., Sato N., Miyoshi K., Kudo T., Hitomi J., Morihara T., Yoneda T., Gomi F., Mori Y., Nakano Y., Takeda J., Tsuda T., Itoyama Y., Murayama O., Takashima A., St George-Hyslop P., Takeda M., Tohyama M. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat. Cell Biol. 1999, 1:479-485.
7. Kouroku Y., Fujita E., Jimbo A., Kikuchi T., Yamagata T., Momoi M.Y., Kominami E., Kuida K., Sakamaki K., Yonehara S., Momoi T. Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum. Mol. Genet. 2002, 11:1505-1515.
8. Koyama Y., Matsuzaki S., Gomi F., Yamada K., Katayama T., Sato K., Kumada T., Fukuda A., Matsuda S., Tano Y., Tohyama M. Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. Invest. Ophthalmol. Vis. Sci. 2008, 49(6):2376-2383.
9. Nakagawa T., Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 2000, 150(4):887-894.
10. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., Yuan J. Caspase-12mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403:98-103.
11. Rao R.V., Hermel E., Castro-Obregon S., del Rio G., Ellerby L.M., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J. Biol. Chem. 2001, 276:33869-33874.
12. Ryu E.J., Harding H.P., Angelastro J.M., Vitolo O.V., Ron D., Greene L.A. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J. Neurosci. 2002, 22:10690-10698.
13. Sorimachi H., Ishiura S., Suzuki K. Structure and physiological function of calpains. Biochem. J. 1997, 328:721-732.
14. Yankner B.A., Dawes L.R., Fisher S., Villa-Komaroff L., Oster-Granite M.L., Neve R.L. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 1989, 245:417-420.
15. Yamagishi S., Koyama Y., Katayama T., Taniguchi M., Hitomi J., Kato M., Aoki M., Itoyama Y., Kato S., Tohyama M. An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation. PLoS One 2007, 2(10):e1030.
16. Yoneda T., Imaizumi K., Oono K., Yui D., Gomi F., Katayama T., Tohyama M. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J. Biol. Chem. 2001, 276:13935-13940.
17. Yukioka F., Matsuzaki S., Kawamoto K., Koyama Y., Hitomi J., Katayama T., Tohyama M. Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis. Neurochem. Int. 2008, 52(4-5):683-687.