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Volumn 31, Issue 2, 2017, Pages 516-521

Implementing a Statistical Model for Protamine Titration: Effects on Coagulation in Cardiac Surgical Patients

Author keywords

cardiac surgery; cardiopulmonary bypass; heparin; protamine; statistical model

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; FIBRINOGEN; HEPARIN; PROTAMINE; TICAGRELOR; HEPARIN ANTAGONIST;

EID: 85000444159     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2016.07.018     Document Type: Article
Times cited : (9)

References (32)
  • 1
    • 33746752738 scopus 로고    scopus 로고
    • Does use of the Hepcon point-of-care coagulation monitor to optimise heparin and protamine dosage for cardiopulmonary bypass decrease bleeding and blood and blood product requirements in adult patients undergoing cardiac surgery?
    • 1 Aziz, K.A., Masood, O., Hoschtitzky, J.A., et al. Does use of the Hepcon point-of-care coagulation monitor to optimise heparin and protamine dosage for cardiopulmonary bypass decrease bleeding and blood and blood product requirements in adult patients undergoing cardiac surgery?. Interact Cardiovasc Thorac Surg 5 (2006), 469–482.
    • (2006) Interact Cardiovasc Thorac Surg , vol.5 , pp. 469-482
    • Aziz, K.A.1    Masood, O.2    Hoschtitzky, J.A.3
  • 2
    • 84896404937 scopus 로고    scopus 로고
    • Individualized heparin and protamine management improves rotational thromboelastometric parameters and postoperative hemostasis in valve surgery
    • 2 Vonk, A.B., Veerhoek, D., van den Brom, C.E., et al. Individualized heparin and protamine management improves rotational thromboelastometric parameters and postoperative hemostasis in valve surgery. J Cardiothorac Vasc Anesth 28 (2014), 235–241.
    • (2014) J Cardiothorac Vasc Anesth , vol.28 , pp. 235-241
    • Vonk, A.B.1    Veerhoek, D.2    van den Brom, C.E.3
  • 3
    • 84991065834 scopus 로고    scopus 로고
    • An adjusted calculation model allows for reduced protamine doses without increasing blood loss in cardiac surgery
    • [Epub ahead of print] Aug 13
    • 3 Kjellberg, G., Sartipy, U., van der Linden, J., et al. An adjusted calculation model allows for reduced protamine doses without increasing blood loss in cardiac surgery. Thorac Cardiovasc Surg, 2015 Aug 13 [Epub ahead of print].
    • (2015) Thorac Cardiovasc Surg
    • Kjellberg, G.1    Sartipy, U.2    van der Linden, J.3
  • 4
    • 84878292095 scopus 로고    scopus 로고
    • Blood loss after cardiopulmonary bypass, standard vs titrated protamine: A meta-analysis
    • 4 Wang, J., Ma, H.P., Zheng, H., Blood loss after cardiopulmonary bypass, standard vs titrated protamine: A meta-analysis. Neth J Med 71 (2013), 123–127.
    • (2013) Neth J Med , vol.71 , pp. 123-127
    • Wang, J.1    Ma, H.P.2    Zheng, H.3
  • 5
    • 8044257128 scopus 로고    scopus 로고
    • More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT
    • 5 Despotis, G.J., Joist, J.H., Hogue, C.W., et al. More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT. Thromb Haemost 76 (1996), 902–908.
    • (1996) Thromb Haemost , vol.76 , pp. 902-908
    • Despotis, G.J.1    Joist, J.H.2    Hogue, C.W.3
  • 6
    • 26244444777 scopus 로고
    • Prediction of blood volume and adiposity in man from body weight and cube of height
    • 6 Allen, T.H., Peng, M.T., Chen, K.P., et al. Prediction of blood volume and adiposity in man from body weight and cube of height. Metabolism 5 (1956), 328–345.
    • (1956) Metabolism , vol.5 , pp. 328-345
    • Allen, T.H.1    Peng, M.T.2    Chen, K.P.3
  • 7
    • 84930082457 scopus 로고    scopus 로고
    • Reversal of heparin after cardiac surgery: Protamine titration using a statistical model
    • 7 Davidsson, F.Ö., Johagen, D., Appelblad, M., et al. Reversal of heparin after cardiac surgery: Protamine titration using a statistical model. J Cardiothorac Vasc Anesth 29 (2015), 710–714.
    • (2015) J Cardiothorac Vasc Anesth , vol.29 , pp. 710-714
    • Davidsson, F.Ö.1    Johagen, D.2    Appelblad, M.3
  • 8
    • 72749100230 scopus 로고    scopus 로고
    • Static blood-flow control during cardiopulmonary bypass is a compromise of oxygen delivery
    • 8 Svenmarker, S., Häggmark, S., Hultin, M., et al. Static blood-flow control during cardiopulmonary bypass is a compromise of oxygen delivery. Eur J Cardiothorac Surg 37 (2010), 218–222.
    • (2010) Eur J Cardiothorac Surg , vol.37 , pp. 218-222
    • Svenmarker, S.1    Häggmark, S.2    Hultin, M.3
  • 9
    • 0001495969 scopus 로고
    • Blutgerinningsstudien mit der thromboelastographie, einem neuen undersuchsverfarhren
    • 9 Hartret, H., Blutgerinningsstudien mit der thromboelastographie, einem neuen undersuchsverfarhren. Klin Wochensehr 26 (1948), 577–583.
    • (1948) Klin Wochensehr , vol.26 , pp. 577-583
    • Hartret, H.1
  • 10
    • 18944366749 scopus 로고    scopus 로고
    • Multi-centre investigation on reference ranges for ROTEM thromboelastometry
    • 10 Lang, T., Bauters, A., Braun, S.L., et al. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis 16 (2005), 301–310.
    • (2005) Blood Coagul Fibrinolysis , vol.16 , pp. 301-310
    • Lang, T.1    Bauters, A.2    Braun, S.L.3
  • 11
    • 84941886412 scopus 로고    scopus 로고
    • Assessing the methodology for calculating platelet contribution to clot Strength (platelet component) in thromboelastometry and thrombelastography
    • 11 Solomon, C., Ranucci, M., Hochleitner, G., et al. Assessing the methodology for calculating platelet contribution to clot Strength (platelet component) in thromboelastometry and thrombelastography. Anesth Analg 121 (2015), 868–878.
    • (2015) Anesth Analg , vol.121 , pp. 868-878
    • Solomon, C.1    Ranucci, M.2    Hochleitner, G.3
  • 12
    • 84937954597 scopus 로고    scopus 로고
    • Can the viscoelastic parameter α-angle distinguish fibrinogen from platelet deficiency and guide fibrinogen supplementation?
    • 12 Solomon, C., Schöchl, H., Ranucci, M., et al. Can the viscoelastic parameter α-angle distinguish fibrinogen from platelet deficiency and guide fibrinogen supplementation?. Anesth Analg 121 (2015), 289–301.
    • (2015) Anesth Analg , vol.121 , pp. 289-301
    • Solomon, C.1    Schöchl, H.2    Ranucci, M.3
  • 13
    • 0031052490 scopus 로고    scopus 로고
    • Heparin detection by the activated coagulation time: A comparison of the sensitivity of coagulation tests and heparin assays
    • 13 Murray, D.J., Brosnahan, W.J., Pennell, B., et al. Heparin detection by the activated coagulation time: A comparison of the sensitivity of coagulation tests and heparin assays. J Cardiothorac Vasc Anesth 11 (1997), 24–28.
    • (1997) J Cardiothorac Vasc Anesth , vol.11 , pp. 24-28
    • Murray, D.J.1    Brosnahan, W.J.2    Pennell, B.3
  • 14
    • 84897051819 scopus 로고    scopus 로고
    • The effects of protamine sulfate on clot formation time and clot strength thromboelastography variables for canine blood samples
    • 14 Bailey, C.J., Koenigshof, A.M., The effects of protamine sulfate on clot formation time and clot strength thromboelastography variables for canine blood samples. Am J Vet Res 75 (2014), 338–343.
    • (2014) Am J Vet Res , vol.75 , pp. 338-343
    • Bailey, C.J.1    Koenigshof, A.M.2
  • 15
    • 0033980698 scopus 로고    scopus 로고
    • Protamine sulphate inhibits platelet membrane glycoprotein Ib-von Willebrand factor activity
    • 15 Barstad, R.M., Stephens, R.W., Hamers, M.J., et al. Protamine sulphate inhibits platelet membrane glycoprotein Ib-von Willebrand factor activity. Thromb Haemost 83 (2000), 334–337.
    • (2000) Thromb Haemost , vol.83 , pp. 334-337
    • Barstad, R.M.1    Stephens, R.W.2    Hamers, M.J.3
  • 16
    • 77956406570 scopus 로고    scopus 로고
    • The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor VIII concentrations
    • 16 Bolliger, D., Szlam, F., Azran, M., et al. The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor VIII concentrations. Anesth Analg 111 (2010), 601–608.
    • (2010) Anesth Analg , vol.111 , pp. 601-608
    • Bolliger, D.1    Szlam, F.2    Azran, M.3
  • 17
    • 0742272009 scopus 로고    scopus 로고
    • Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery
    • 17 Avidan, M.S., Alcock, E.L., Da Fonseca, J., et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth 92 (2004), 178–186.
    • (2004) Br J Anaesth , vol.92 , pp. 178-186
    • Avidan, M.S.1    Alcock, E.L.2    Da Fonseca, J.3
  • 18
    • 77953785460 scopus 로고    scopus 로고
    • The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph
    • 18 Khan, N.U., Wayne, C.K., Barker, J., et al. The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph. Eur J Anaesthesiol 27 (2010), 624–627.
    • (2010) Eur J Anaesthesiol , vol.27 , pp. 624-627
    • Khan, N.U.1    Wayne, C.K.2    Barker, J.3
  • 19
    • 84896854630 scopus 로고    scopus 로고
    • Protamine overdose and its impact on coagulation, bleeding, and transfusions after cardiopulmonary bypass: Results of a randomized double-blind controlled pilot study
    • 19 Koster, A., Börgermann, J., Gummert, J., et al. Protamine overdose and its impact on coagulation, bleeding, and transfusions after cardiopulmonary bypass: Results of a randomized double-blind controlled pilot study. Clin Appl Thromb Hemost 20 (2014), 290–295.
    • (2014) Clin Appl Thromb Hemost , vol.20 , pp. 290-295
    • Koster, A.1    Börgermann, J.2    Gummert, J.3
  • 20
    • 84957839961 scopus 로고    scopus 로고
    • Calculating the protamine dose necessary to neutralize heparin in all patients under all circumstances
    • 20 de Jong, J.R., Boer, C., Calculating the protamine dose necessary to neutralize heparin in all patients under all circumstances. J Cardiothorac Vasc Anesth 30 (2016), e6–e7.
    • (2016) J Cardiothorac Vasc Anesth , vol.30 , pp. e6-e7
    • de Jong, J.R.1    Boer, C.2
  • 21
    • 0030888878 scopus 로고    scopus 로고
    • Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements
    • 21 Despotis, G.J., Joist, J.H., Goodnough, L.T., et al. Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements. J Thorac Cardiovasc Surg 113 (1997), 611–613.
    • (1997) J Thorac Cardiovasc Surg , vol.113 , pp. 611-613
    • Despotis, G.J.1    Joist, J.H.2    Goodnough, L.T.3
  • 22
    • 0031687988 scopus 로고    scopus 로고
    • Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass
    • 22 Mochizuki, T., Olson, P.J., Szlam, F., et al. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. Anesth Analg 87 (1998), 781–785.
    • (1998) Anesth Analg , vol.87 , pp. 781-785
    • Mochizuki, T.1    Olson, P.J.2    Szlam, F.3
  • 23
    • 84983185886 scopus 로고    scopus 로고
    • Protamine reduces whole blood platelet aggregation after cardiopulmonary bypass
    • 23 Olsson, A., Alfredsson, J., Håkansson, E., et al. Protamine reduces whole blood platelet aggregation after cardiopulmonary bypass. Scand Cardiovasc J 50 (2015), 58–63.
    • (2015) Scand Cardiovasc J , vol.50 , pp. 58-63
    • Olsson, A.1    Alfredsson, J.2    Håkansson, E.3
  • 24
    • 84876687684 scopus 로고    scopus 로고
    • Point-of-care assessment of hypothermia and protamine-induced platelet dysfunction with multiple electrode aggregometry (Multiplate®) in patients undergoing cardiopulmonary bypass
    • 24 Ortmann, E., Klein, A.A., Sharples, L.D., et al. Point-of-care assessment of hypothermia and protamine-induced platelet dysfunction with multiple electrode aggregometry (Multiplate®) in patients undergoing cardiopulmonary bypass. Anesth Analg 116 (2013), 533–540.
    • (2013) Anesth Analg , vol.116 , pp. 533-540
    • Ortmann, E.1    Klein, A.A.2    Sharples, L.D.3
  • 25
    • 70349581807 scopus 로고    scopus 로고
    • Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation
    • 25 Ni Ainle, F., Preston, R.J., Jenkins, P.V., et al. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood 114 (2009), 1658–1665.
    • (2009) Blood , vol.114 , pp. 1658-1665
    • Ni Ainle, F.1    Preston, R.J.2    Jenkins, P.V.3
  • 26
    • 84873477675 scopus 로고    scopus 로고
    • Impact of protamine dose on activated clotting time and thromboelastography in infants and small children undergoing cardiopulmonary bypass
    • 26 Gautam, N.K., Schmitz, M.L., Harrison, D., et al. Impact of protamine dose on activated clotting time and thromboelastography in infants and small children undergoing cardiopulmonary bypass. Paediatr Anaesth 23 (2013), 233–241.
    • (2013) Paediatr Anaesth , vol.23 , pp. 233-241
    • Gautam, N.K.1    Schmitz, M.L.2    Harrison, D.3
  • 27
    • 33646827821 scopus 로고    scopus 로고
    • Protamine enhances fibrinolysis by decreasing clot strength: Role of tissue factor-initiated thrombin generation
    • 27 Nielsen, V.G., Protamine enhances fibrinolysis by decreasing clot strength: Role of tissue factor-initiated thrombin generation. Ann Thorac Surg 81 (2006), 1720–1727.
    • (2006) Ann Thorac Surg , vol.81 , pp. 1720-1727
    • Nielsen, V.G.1
  • 28
    • 82255196088 scopus 로고    scopus 로고
    • Are the point-of-care diagnostics MULTIPLATE and ROTEM valid in the setting of high concentrations of heparin and its reversal with protamine?
    • 28 Gertler, R., Wiesner, G., Tassani-Prell, P., et al. Are the point-of-care diagnostics MULTIPLATE and ROTEM valid in the setting of high concentrations of heparin and its reversal with protamine?. J Cardiothorac Vasc Anesth 25 (2011), 981–986.
    • (2011) J Cardiothorac Vasc Anesth , vol.25 , pp. 981-986
    • Gertler, R.1    Wiesner, G.2    Tassani-Prell, P.3
  • 29
    • 61949353495 scopus 로고    scopus 로고
    • The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia
    • 29 Lang, T., Johanning, K., Metzler, H., et al. The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia. Anesth Analg 108 (2009), 751–758.
    • (2009) Anesth Analg , vol.108 , pp. 751-758
    • Lang, T.1    Johanning, K.2    Metzler, H.3
  • 30
    • 84872162974 scopus 로고    scopus 로고
    • Fibrinogen concentration significantly decreases after on-pump versus off-pump coronary artery bypass surgery: A systematic point-of-care ROTEM analysis
    • 30 Momeni, M., Carlier, C., Baele, P., et al. Fibrinogen concentration significantly decreases after on-pump versus off-pump coronary artery bypass surgery: A systematic point-of-care ROTEM analysis. J Cardiothorac Vasc Anesth 27 (2013), 5–11.
    • (2013) J Cardiothorac Vasc Anesth , vol.27 , pp. 5-11
    • Momeni, M.1    Carlier, C.2    Baele, P.3
  • 31
    • 0022627564 scopus 로고
    • Effects of protamine administration after cardiopulmonary bypass on complement, blood elements, and the hemodynamic state
    • 31 Kirklin, J.K., Chenoweth, D.E., Naftel, D.C., et al. Effects of protamine administration after cardiopulmonary bypass on complement, blood elements, and the hemodynamic state. Ann Thorac Surg 41 (1986), 193–199.
    • (1986) Ann Thorac Surg , vol.41 , pp. 193-199
    • Kirklin, J.K.1    Chenoweth, D.E.2    Naftel, D.C.3
  • 32
    • 84905728619 scopus 로고    scopus 로고
    • Reappearance of circulating heparin in whole blood heparin concentration-based management does not correlate with postoperative bleeding after cardiac surgery
    • 32 Ichikawa, J., Kodaka, M., Nishiyama, K., et al. Reappearance of circulating heparin in whole blood heparin concentration-based management does not correlate with postoperative bleeding after cardiac surgery. J Cardiothorac Vasc Anesth 28 (2014), 1003–1007.
    • (2014) J Cardiothorac Vasc Anesth , vol.28 , pp. 1003-1007
    • Ichikawa, J.1    Kodaka, M.2    Nishiyama, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.