Protamine reduces whole blood platelet aggregation after cardiopulmonary bypass

Scandinavian Cardiovascular Journal

Volumn 50, Issue 1, 2016, Pages 58-63

  Olsson, Anki ^a,b   Alfredsson, Joakim ^c   Håkansson, Erik ^b   Svedjeholm, Rolf ^c   Berglund, Johan ^a   Berg, Sören ^b  

^a BLEKINGE INSTITUTE OF TECHNOLOGY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Cardiopulmonary bypass; platelet aggregation; platelet function tests; protamine

Indexed keywords

ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; COLLAGEN; HEPARIN; PROTAMINE; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; ANTICOAGULANT AGENT; HEPARIN ANTAGONIST;

AGED; ANTICOAGULANT THERAPY; ARTICLE; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; ADVERSE EFFECTS; BLOOD; BLOOD CLOTTING PARAMETERS; CHEMICALLY INDUCED; DOWN REGULATION; DRUG EFFECTS; HEART SURGERY; MIDDLE AGED; PILOT STUDY; RISK FACTOR; TREATMENT OUTCOME;

AGED; ANTICOAGULANTS; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; DOWN-REGULATION; FEMALE; HEPARIN; HEPARIN ANTAGONISTS; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; POSTOPERATIVE HEMORRHAGE; PROTAMINES; RISK FACTORS; TREATMENT OUTCOME;

EID: 84983185886     PISSN: 14017431     EISSN: 16512006     Source Type: Journal    
DOI: 10.3109/14017431.2015.1099720     Document Type: Article

References (15)

1. Harker LA. Bleeding after cardiopulmonary bypass. N Engl J Med. 1986; 314: 1446-1448.
2. Woodman RC, Harker LA. Bleeding complications associated with cardiopulmonary bypass. Blood. 1990; 76: 1680-1697.
3. Ellison N, Edmunds LH Jr, Colman RW. Platelet aggregation following heparin and protamine administration. Anesthesiology. 1978; 48: 65-68.
4. Griffin MJ, Rinder HM, Smith BR, et al. The effects of heparin, protamine, and heparin/protamine reversal on platelet function under conditions of arterial shear stress. Anesth Analg. 2001; 93: 20-27.
5. Mochizuki T, Olson PJ, Szlam F, et al. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. Anesth Analg. 1998; 87: 781-785.
6. Carr ME Jr, Carr SL. At high heparin concentrations, protamine concentrations which reverse heparin anticoagulant effects are insufficient to reverse heparin anti-platelet effects. Thromb Res. 1994; 75: 617-630.
7. Cardinal DC, Flower RJ. The electronic aggregometer: A novel device for assessing platelet behavior in blood. J Pharmacol Methods. 1980; 3: 135-158.
8. Mclaughlin KE, Dunning J. In patients post cardiac surgery do high doses of protamine cause increased bleeding? Interact CardioVasc Thorac Surg. 2003; 2: 424-426.
9. Ammar T, Fisher CF. The effects of heparinase 1 and protamine on platelet reactivity. Anesthesiology. 1997; 86: 1382-1386.
10. Lindblad B, Wakefield TW, Whitehouse WM Jr, et al. The effect of protamine sulfate on platelet function. Scand J Thorac Cardiovasc Surg. 1988; 22: 55-59.
11. Gertler R, Wiesner G, Tassani-Prell P, et al. Are the point-of-care diagnostics MULTIPLATE and ROTEM valid in the setting of high concentrations of heparin and its reversal with protamine? J Cardiothorac Vasc Anesth. 2011; 25: 981-986.
12. Ferraris VA, Ferraris SP, Singh A, et al. The platelet thrombin receptor and postoperative bleeding. Ann Thorac Surg. 1998; 65: 352-358.
13. Ortmann E, Klein AA, Sharples LD, et al. Point-of-care assessment of hypothermia and protamine-induced platelet dysfunction with multiple electrode aggregometry (Multiplate(R)) in patients undergoing cardiopulmonary bypass. Anesth Analg. 2013; 116: 533-540.
14. Ranucci M, Baryshnikova E, Soro G, et al. Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg. 2011; 91: 123-129.
15. Rubak P, Villadsen K, Hvas A-M. Reference intervals for platelet aggregation assessed by multiple electrode platelet aggregometry. Thromb Res. 2012; 130: 420-423.