Assessing the methodology for calculating platelet contribution to clot strength (platelet component) in thromboelastometry and thrombelastography

Anesthesia and Analgesia

Volumn 121, Issue 4, 2015, Pages 868-878

  Solomon, Cristina ^a,b,c   Ranucci, Marco ^d   Hochleitner, Gerald ^e   Schochl, Herbert ^c   Schlimp, Christoph J ^b,f  

^a CSL BEHRING GMBH   (Germany)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

^c LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^e CSL Behring   (Austria)

^f Trauma Hospital Salzburg   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; FIBRINOGEN;

ALGORITHM; BLOOD CLOTTING; BLOOD COMPONENT; BLOOD EXAMINATION; HEMATOLOGICAL PARAMETERS; HUMAN; METHODOLOGY; PRIORITY JOURNAL; REVIEW; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA; THROMBOELASTOGRAPH; THROMBOELASTOGRAPHY; THROMBOELASTOMETRY; VISCOELASTICITY; YOUNG MODULUS; ELASTICITY; PHYSIOLOGY; PROCEDURES; STANDARDS; THROMBOCYTE;

BLOOD COAGULATION; BLOOD PLATELETS; ELASTICITY; HUMANS; PLATELET COUNT; THROMBELASTOGRAPHY;

EID: 84941886412     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000000859     Document Type: Review

References (79)

1. Bajd F, Vidmar J, Fabjan A, Blinc A, Kralj E, Bizjak N, Serša I. Impact of altered venous hemodynamic conditions on the formation of platelet layers in thromboemboli. Thromb Res 2012;129:158-63
2. Khurana S, Mattson JC, Westley S, O'Neill WW, Timmis GC, Safian RD. Monitoring platelet glycoprotein IIb/IIIa-fibrin interaction with tissue factor-activated thromboelastography. J Lab Clin Med 1997;130:401-11
3. Lam WA, Chaudhuri O, Crow A, Webster KD, Li TD, Kita A, Huang J, Fletcher DA. Mechanics and contraction dynamics of single platelets and implications for clot stiffening. Nat Mater 2011;10:61-6
4. Nielsen VG, Gurley WQ Jr, Burch TM. The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastography. Anesth Analg 2004;99:120-3
5. Solomon C, Rahe-Meyer N, Sørensen B. Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery. Thromb Res 2011;128:277-82
6. Lang T, Johanning K, Metzler H, Piepenbrock S, Solomon C, Rahe-Meyer N, Tanaka KA. The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia. Anesth Analg 2009;108:751-8
7. Nielsen VG, Geary BT, Baird MS. Evaluation of the contribution of platelets to clot strength by thromboelastography in rabbits: the role of tissue factor and cytochalasin D. Anesth Analg 2000;91:35-9
8. Riley JB, Stammers AH. A technique to give clinical relevance to parameters from the thromboelastograph. J Extra-Corpor Technol 1992;23:112-24
9. Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg 2008;106:1366-75
10. Burghardt WR, Goldstick TK, Leneschmidt J, Kempka K. Nonlinear viscoelasticity and the thrombelastograph: 1. Studies on bovine plasma clots. Biorheology 1995;32:621-30
11. Scott-Blair GW. In: Copley AL, Stainsby G, eds. Flow Properties of Blood and Other Biological Systems. Oxford, UK: Pergamon, 1960:63-83
12. Schmitt C, Hadj Henni A, Cloutier G. Characterization of blood clot viscoelasticity by dynamic ultrasound elastography and modeling of the rheological behavior. J Biomech 2011;44:622-9
13. Miguel B, Gennisson J-L, Fink M, Tanter M. Cross validation of Supersonic Shear Wave Imaging (SSI) with classical rheometry during blood coagulation over a very large bandwidth. Presented at Institute of Electrical and Electronics Engineers (IEEE) International Conference, Prague, July 2013
14. Chandler WL. The thromboelastography and the thromboelastograph technique. Semin Thromb Hemost 1995;21(suppl 4):1-6
15. Ranucci M, Laddomada T, Ranucci M, Baryshnikova E. Blood viscosity during coagulation at different shear rates. Physiol Rep 2014;2:pii:e12065
16. Cines DB, Lebedeva T, Nagaswami C, Hayes V, Massefski W, Litvinov RI, Rauova L, Lowery TJ, Weisel JW. Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin. Blood 2014;123:1596-603
17. Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Banerjee A, Silliman CC, Sauaia A. Platelets are dominant contributors to hypercoagulability after injury. J Trauma Acute Care Surg 2013;74:756-62
18. Harr JN, Moore EE, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock 2013;39:45-9
19. Hartert H. [Blutgerinnungstudien mit der Thrombelastographic einen neven Untersuchungsverfahren.]. Klin Wochenschr 1948;26:577-83
20. Hartert H. Thrombelastography: physical and physiological aspects. In: Copley AL, Stainsby G, eds. Flow Properties of Blood and Other Biological Systems. Oxford, UK: Pergamon, 1960:186-98
21. Hartert H, Schaeder JA. The physical and biological constants of thrombelastography. Biorheology 1962;1:31-9
22. da Luz LT, Nascimento B, Rizoli S. Thrombelastography (TEG (R)): practical considerations on its clinical use in trauma resuscitation. Scand J Trauma Resusc Emerg Med 2013;21:29
23. Haemoscope Corporation. TEG 5000 Thrombelastograph hemostasis system: user manual. Available at: http://diamedil. info/MediGal/Technical%20Support/PN06-510-TEG-UserManual-v4-3-2008-10.PDF. Accessed August 2014
24. Evans PA, Hawkins K, Williams PR. Rheometry for blood coagulation studies. Rheology Rev 2006:255-91
25. Dekker SE, Viersen VA, Duvekot A, de Jong M, van den Brom CE, van de Ven PM, Schober P, Boer C. Lysis onset time as diagnostic rotational thromboelastometry parameter for fast detection of hyperfibrinolysis. Anesthesiology 2014;121:89-97
26. Kettner SC, Panzer OP, Kozek SA, Seibt FA, Stoiser B, Kofler J, Locker GJ, Zimpfer M. Use of abciximab-modified thrombelastography in patients undergoing cardiac surgery. Anesth Analg 1999;89:580-4
27. Lang T, von Depka M. Possibilities and limitations of thromboelastometry/thromboelastography. Hamostaseologie 2006;26(suppl 1):S21-9
28. ®) findings between humans and baboons. Thromb Res 2012;130:e107-12
29. Kozek-Langenecker SA, Afshari A, Albaladejo P, Santullano CA, De Robertis E, Filipescu DC, Fries D, Görlinger K, Haas T, Imberger G, Jacob M, Lancé M, Llau J, Mallett S, Meier J, Rahe-Meyer N, Samama CM, Smith A, Solomon C, Van der Linden P, Wikkelsø AJ, Wouters P, Wyffels P. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2013;30:270-382
30. Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Ambrose JA. Effects of cigarette smoke exposure on clot dynamics and fibrin structure: an ex vivo investigation. Arterioscler Thromb Vasc Biol 2010;30:75-9
31. Cartwright BL, Kam P, Yang K. Efficacy of fibrinogen concentrate compared with cryoprecipitate for reversal of the antiplatelet effect of clopidogrel in an in vitro model, as assessed by multiple electrode platelet aggregometry, thromboelastometry, and modified thromboelastography. J Cardiothorac Vasc Anesth 2015;29:694-702
32. Chandler WL, Patel MA, Gravelle L, Soltow LO, Lewis K, Bishop PD, Spiess BD. Factor XIIIA and clot strength after cardiopulmonary bypass. Blood Coagul Fibrinolysis 2001;12:101-8
33. ™) increases survival and corrects coagulopathy after eight-minute asphyxial cardiac arrest in the rat. Shock 2013;40:222-32
34. Haizinger B, Gombotz H, Rehak P, Geiselseder G, Mair R. Activated thrombelastogram in neonates and infants with complex congenital heart disease in comparison with healthy children. Br J Anaesth 2006;97:545-52
35. Mahla E, Lang T, Vicenzi MN, Werkgartner G, Maier R, Probst C, Metzler H. Thromboelastography for monitoring prolonged hypercoagulability after major abdominal surgery. Anesth Analg 2001;92:572-7
36. Nielsen VG, Geary BT. Thoracic aorta occlusion-reperfusion decreases hemostasis as assessed by thromboelastography in rabbits. Anesth Analg 2000;91:517-21
37. Pérez-Ferrer A, Navarro-Suay R, Viejo-Llorente A, Alcaide-Martín MJ, de Vicente-Sánchez J, Butta N, de Prádena Y Lobón JM, Povo-Castilla J. In vitro thromboelastometric evaluation of the efficacy of frozen platelet transfusion. Thromb Res 2015; pii: S0049-3848(15)30012-8
38. Solomon C, Traintinger S, Ziegler B, Hanke A, Rahe-Meyer N, Voelckel W, Schöchl H. Platelet function following trauma. A multiple electrode aggregometry study. Thromb Haemost 2011;106:322-30
39. Solomon C, Baryshnikova E, Schlimp CJ, Schöchl H, Asmis LM, Ranucci M. FIBTEM PLUS provides an improved thromboelastometry test for measurement of fibrin-based clot quality in cardiac surgery patients. Anesth Analg 2013;117:1054-62
40. Solomon C, Hagl C, Rahe-Meyer N. Time course of haemostatic effects of fibrinogen concentrate administration in aortic surgery. Br J Anaesth 2013;110:947-56
41. Torres LN, Sondeen JL, Ji L, Dubick MA, Torres Filho I. Evaluation of resuscitation fluids on endothelial glycocalyx, venular blood flow, and coagulation function after hemorrhagic shock in rats. J Trauma Acute Care Surg 2013;75:759-66
42. Bontekoe IJ, van der Meer PF, de Korte D. Determination of thromboelastographic responsiveness in stored single-donor platelet concentrates. Transfusion 2014;54:1610-8
43. Cui Y, Hei F, Long C, Feng Z, Zhao J, Yan F, Wang Y, Liu J. Perioperative monitoring of thromboelastograph on hemostasis and therapy for cyanotic infants undergoing complex cardiac surgery. Artif Organs 2009;33:909-14
44. Cui Y, Hei F, Long C, Feng Z, Zhao J, Yan F, Wang Y, Liu J. Perioperative monitoring of thromboelastograph on blood protection and recovery for severely cyanotic patients undergoing complex cardiac surgery. Artif Organs 2010;34:955-60
45. Faybik P, Bacher A, Kozek-Langenecker SA, Steltzer H, Krenn CG, Unger S, Hetz H. Molecular adsorbent recirculating system and hemostasis in patients at high risk of bleeding: an observational study. Crit Care 2006;10:R24
46. García-Monteavaro ML, Rodríguez M, Díez ML, Navarro A. Thromboelastographic assays of the clotting process in situations of obesity and caloric restriction. Rev Esp Fisiol 1986;42:57-62
47. Godier A, Durand M, Smadja D, Jeandel T, Emmerich J, Samama CM. Maize- or potato-derived hydroxyethyl starches: is there any thromboelastometric difference? Acta Anaesthesiol Scand 2010;54:1241-7
48. Gottumukkala VN, Sharma SK, Philip J. Assessing platelet and fibrinogen contribution to clot strength using modified thromboelastography in pregnant women. Anesth Analg 1999;89:1453-5
49. Greilich PE, Alving BM, O'Neill KL, Chang AS, Reid TJ. A modified thromboelastographic method for monitoring c7E3 Fab in heparinized patients. Anesth Analg 1997;84:31-8
50. Harnett MJ, Bhavani-Shankar K, Datta S, Tsen LC. In vitro fertilization-induced alterations in coagulation and fibrinolysis as measured by thromboelastography. Anesth Analg 2002;95:1063-6
51. Harnett MJ, Hepner DL, Datta S, Kodali BS. Effect of amniotic fluid on coagulation and platelet function in pregnancy: an evaluation using thromboelastography. Anaesthesia 2005;60:1068-72
52. ® and MEA in a cardiac surgical patient with ITP. J Anesth 2014;28:310
53. Kessler U, Grau T, Gronchi F, Berger S, Brandt S, Bracht H, Marcucci C, Zachariou Z, Jakob SM. Comparison of porcine and human coagulation by thrombelastometry. Thromb Res 2011;128:477-82
54. Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ. Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis. J Trauma Acute Care Surg 2014;76:255-63
55. Kuitunen AH, Suojaranta-Ylinen RT, Kukkonen SI, Niemi TT. Tranexamic acid does not correct the haemostatic impairment caused by hydroxyethyl starch (200 kDa/0.5) after cardiac surgery. Blood Coagul Fibrinolysis 2006;17:639-45
56. Larsen AM, Leinoe EB, Johansson PI, Birgens H, Ostrowski SR. Haemostatic function and biomarkers of endothelial damage before and after RBC transfusion in patients with haematologic disease. Vox Sang 2015;109:52-61
57. Lindroos AC, Schramko AA, Niiya T, Suojaranta-Ylinen RT, Niemi TT. Effects of combined balanced colloid and crystalloid on rotational thromboelastometry in vitro. Perfusion 2011;26:422-7
58. Miller BE, Tosone SR, Guzzetta NA, Miller JL, Brosius KK. Fibrinogen in children undergoing cardiac surgery: is it effective? Anesth Analg 2004;99:1341-6
59. Monaca E, Strelow H, Jüttner T, Hoffmann T, Potempa T, Windolf J, Winterhalter M. Assessment of hemostaseologic alterations induced by hyperbaric oxygen therapy using pointofcare analyzers. Undersea Hyperb Med 2014;41:17-26
60. Niemi TT, Suojaranta-Ylinen RT, Kukkonen SI, Kuitunen AH. Gelatin and hydroxyethyl starch, but not albumin, impair hemostasis after cardiac surgery. Anesth Analg 2006;102:998-1006
61. Olde Engberink RH, Kuiper GJ, Wetzels RJ, Nelemans PJ, Lance MD, Beckers EA, Henskens YM. Rapid and correct prediction of thrombocytopenia and hypofibrinogenemia with rotational thromboelastometry in cardiac surgery. J Cardiothorac Vasc Anesth 2014;28:210-6
62. Ostrowski SR, Berg RM, Windeløv NA, Meyer MA, Plovsing RR, Møller K, Johansson PI. Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers. PLoS One 2013;8:e59368
63. Oswald E, Streif W, Hermann M, Hengster P, Mittermayr M, Innerhofer P. Intraoperatively salvaged red blood cells contain nearly no functionally active platelets, but exhibit formation of microparticles: results of a pilot study in orthopedic patients. Transfusion 2010;50:400-6
64. Rahe-Meyer N, Solomon C, Tokuno ML, Winterhalter M, Shrestha M, Hahn A, Tanaka K. Comparative assessment of coagulation changes induced by two different types of heartlung machine. Artif Organs 2010;34:3-12
65. Reid TJ, Snider R, Hartman K, Greilich PE, Carr ME, Alving BM. A method for the quantitative assessment of plateletinduced clot retraction and clot strength in fresh and stored platelets. Vox Sang 1998;75:270-7
66. Schöchl H, Frietsch T, Pavelka M, Jámbor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 2009;67:125-31
67. Schramko AA, Suojaranta-Ylinen RT, Kuitunen AH, Kukkonen SI, Niemi TT. Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial. Anesth Analg 2009;108:30-6
68. Schramko A, Suojaranta-Ylinen R, Niemi T, Pesonen E, Kuitunen A, Raivio P, Salmenperä M. The use of balanced HES 130/0.42 during complex cardiac surgery; effect on blood coagulation and fluid balance: a randomized controlled trial. Perfusion 2015;30:224-32
69. Sivula M, Pettilä V, Niemi TT, Varpula M, Kuitunen AH. Thromboelastometry in patients with severe sepsis and disseminated intravascular coagulation. Blood Coagul Fibrinolysis 2009;20:419-26
70. Tynngård N, Berlin G, Samuelsson A, Berg S. Low dose of hydroxyethyl starch impairs clot formation as assessed by viscoelastic devices. Scand J Clin Lab Invest 2014;74:344-50
71. Winstedt D, Hanna J, Schött U. Albumin-induced coagulopathy is less severe and more effectively reversed with fibrinogen concentrate than is synthetic colloid-induced coagulopathy. Scand J Clin Lab Invest 2013;73:161-9
72. Westbrook AJ, Olsen J, Bailey M, Bates J, Scully M, Salamonsen RF. Protocol based on thromboelastograph (TEG) out-performs physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery: a pilot study. Heart Lung Circ 2009;18:277-88
73. Bochsen L, Wiinberg B, Kjelgaard-Hansen M, Steinbrüchel DA, Johansson PI. Evaluation of the TEG platelet mapping assay in blood donors. Thromb J 2007;5:3
74. Görlinger K, Dirkmann D, Hanke AA, Kamler M, Kottenberg E, Thielmann M, Jakob H, Peters J. First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, singlecenter cohort study. Anesthesiology 2011;115:1179-91
75. Schöchl H, Voelckel W, Grassetto A, Schlimp CJ. Practical application of point-of-care coagulation testing to guide treatment decisions in trauma. J Trauma Acute Care Surg 2013;74:1587-98
76. Johansson PI, Stensballe J. Effect of haemostatic control resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sang 2009;96:111-8
77. Falco S, Zanatta R, Bruno B, Maurella C, Scalone A, Tarducci A, Borrelli A. Thromboelastometry used for evaluation of blood coagulability in dogs with kidney diseases. Acta Vet Brno 2013;82:209-14
78. Bolliger D, Seeberger MD, Tanaka KA. Principles and practice of thromboelastography in clinical coagulation management and transfusion practice. Transfus Med Rev 2012;26:1-13
79. Bowbrick VA, Mikhailidis DP, Stansby G. Influence of platelet count and activity on thromboelastography parameters. Platelets 2003;14:219-24