Protamine Enhances Fibrinolysis by Decreasing Clot Strength: Role of Tissue Factor-Initiated Thrombin Generation

Annals of Thoracic Surgery

Volumn 81, Issue 5, 2006, Pages 1720-1727

  Nielsen, Vance G ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTAMINE; THROMBIN; THROMBOPLASTIN; TISSUE PLASMINOGEN ACTIVATOR; HEPARIN ANTAGONIST; INFUSORIAL EARTH;

ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; BLOOD CLOTTING TIME; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; FIBRINOLYSIS; HUMAN; KINETICS; MEDICAL INSTRUMENTATION; PLASMA; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; THROMBIN TIME; THROMBOELASTOGRAPHY; DRUG EFFECT; PHYSIOLOGY;

BLOOD COAGULATION; DIATOMACEOUS EARTH; FIBRINOLYSIS; HEPARIN ANTAGONISTS; HUMANS; PLASMA; PROTAMINES; THROMBELASTOGRAPHY; THROMBIN; THROMBOPLASTIN;

EID: 33646827821     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2005.12.027     Document Type: Article

References (16)

1. Gravlee G.P., Haddon W.S., Rothberger H.K., et al. Heparin dosing and monitoring for cardiopulmonary bypass. A comparison of techniques with measurement of subclinical plasma coagulation. J Thorac Cardiovasc Surg 99 (1990) 518-527
2. DeLaria G.A., Tyner J.J., Hayes C.L., and Armstrong B.W. Heparin-protamine mismatch. A controllable factor in bleeding after open heart surgery. Arch Surg 129 (1994) 944-950
3. Jobes D.R., Aitken G.L., and Shaffer G.W. Increased accuracy and precision of heparin and protamine dosing reduces blood loss and transfusion in patients undergoing primary cardiac operations. J Thorac Cardiovasc Surg 110 (1995) 36-45
4. McLaughlin K.E., and Dunning J. In patients post cardiac surgery do high doses of protamine cause increased bleeding?. Interactive Cardiovascular and Thoracic Surgery 2 (2003) 424-426
5. Cobel-Geard R.J., and Hassouna H.I. Interaction of protamine sulfate with thrombin. Am J Hematol 14 (1983) 227-233
6. Chu A.J., Wang Z., Raicu M., Beydoun S., and Ramos N. Protamine inhibits tissue factor-initiated extrinsic coagulation. Br J Haematol 115 (2001) 392-399
7. Mochizuki T., Olson P.J., Szlam F., Ramsay J.G., and Levy J.H. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. Anesth Analg 87 (1998) 781-785
8. Kozek-Langenecker S.A., Mohammad S.F., Masaki T., Kamerath C., and Cheung A.K. The effects of heparin, protamine, and heparinase 1 on platelets in vitro using whole blood flow cytometry. Anesth Analg 90 (2000) 808-812
9. Griffin M.J., Rinder H.M., Smith B.R., et al. The effects of heparin, protamine, and heparin/protamine reversal on platelet function under conditions of arterial shear stress. Anesth Analg 93 (2001) 20-27
10. Butterworth J., Lin Y.A., Prielipp R., Bennett J., and James R. Pharmacokinetics and cardiovascular effects of a single intravenous dose of protamine in normal volunteers. Anesth Analg 94 (2002) 514-522
11. Butterworth J., Lin Y.A., Prielipp R.C., Bennet J., Hammon J.W., and James R.L. Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass. Ann Thorac Surg 74 (2002) 1589-1595
12. Nielsen V.G., Cohen B.M., and Cohen E. Elastic modulus-based thrombelastographic quantification of plasma clot fibrinolysis with progressive plasminogen activation. Blood Coagul Fibrinolysis 17 (2006) 75-81
13. Nielsen V.G., Cohen B.M., and Cohen E. Effects of coagulation factor deficiency on plasma coagulation kinetics determined via Thrombelastography 3. critical roles of fibrinogen and factors II, VII, X and XII. Acta Anaesthesiol Scand 49 (2005) 222-231
14. Despotis G.J., Joist J.H., Hogue C.W., et al. The impact of heparin concentration and activated clotting time monitoring on blood conservation. a prospective, randomized evaluation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg 110 (1995) 46-54
15. Teoh K.H.T., Young E., Blackall M.H., Roberts R.S., and Hirsh J. Can extra protamine eliminate heparin rebound following cardiopulmonary bypass surgery?. J Thorac Cardiovasc Surg 128 (2004) 211-219
16. Khalil P.H., Ismail M., Kalmar P., von Knobelsdorff G., and Marx G. Activation of fibrinolysis in the pericardial cavity after cardiopulmonary bypass. Thromb Haemost 92 (2004) 568-574