Point-of-care assessment of hypothermia and protamine-induced platelet dysfunction with multiple electrode aggregometry (Multiplate®) in patients undergoing cardiopulmonary bypass

Anesthesia and Analgesia

Volumn 116, Issue 3, 2013, Pages 533-540

  Ortmann, Erik ^a   Klein, Andrew A ^a   Sharples, Linda D ^b   Walsh, Racheal ^c   Jenkins, David P ^a   Luddington, Roger J ^c   Besser, Martin W ^c  

^a PAPWORTH HOSPITAL   (United Kingdom)

^b MRC BIOSTATISTICS UNIT   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR CONCENTRATE; CALCIUM; HEMOGLOBIN; PROTAMINE; THROMBIN RECEPTOR;

ACID BASE BALANCE; ADULT; AGED; ARTICLE; BLOOD CLOTTING TIME; BLOOD PH; BLOOD SAMPLING; BODY TEMPERATURE; CALCIUM BLOOD LEVEL; CARDIOPULMONARY BYPASS; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; CLINICAL ARTICLE; ENDARTERECTOMY; ERYTHROCYTE; FEMALE; FLUID THERAPY; HEMATOCRIT; HEMODILUTION; HEPARINIZATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INDUCED HYPOTHERMIA; LABORATORY DEVICE; MALE; MULTIPLE ELECTRODE AGGREGOMETRY; POINT OF CARE TESTING; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE DYSFUNCTION; THROMBOCYTE FUNCTION; WARMING;

ADULT; CARDIOPULMONARY BYPASS; ELECTRODES; HUMANS; HYPOTHERMIA, INDUCED; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; POINT-OF-CARE SYSTEMS; PROTAMINES;

EID: 84876687684     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31827cee88     Document Type: Article

References (24)

1. Paparella D, Brister SJ, Buchanan MR. Coagulation disorders of cardiopulmonary bypass: a review. Intensive Care Med 2004;30:1873-81
2. Besser MW, Klein AA. The coagulopathy of cardiopulmonary bypass. Crit Rev Clin Lab Sci 2010;47:197-212
3. Romlin B, Petruson K, Nilsson K. Moderate superficial hypothermia prolongs bleeding time in humans. Acta Anaesthesiol Scand 2007;51:198-201
4. Rajagopalan S, Mascha E, Na J, Sessler DI. The effects of mild perioperative hypothermia on blood loss and transfusion requirement. Anesthesiology 2008;108:71-7
5. Reece MJ, Klein AA, Salviz EA, Hastings A, Ashworth A, Freeman C, Luddington RJ, Nair S, Besser MW. Near-patient platelet function testing in patients undergoing coronary artery surgery: a pilot study. Anaesthesia 2011;66:97-103
6. Kotake Y, Ogawa NE, Katori N, Serita R, Morisaki H, Takeda J. Platelet dysfunction during cardiopulmonary bypass assessed by a novel whole-blood aggregometer. J Cardiothorac Vasc Anesth 2006;20:536-40
7. Wahba A, Rothe G, Lodes H, Barlage S, Schmitz G, Birnbaum DE. Effects of extracorporeal circulation and heparin on the phenotype of platelet surface antigens following heart surgery. Thromb Res 2000;97:379-86
8. Xiao Z, Théroux P. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a lowmolecular-weight heparin and with a direct thrombin inhibitor. Circulation 1998;97:251-6
9. Muriithi EW, Belcher PR, Day SP, Menys VC, Wheatley DJ. Heparin-induced platelet dysfunction and cardiopulmonary bypass. Ann Thorac Surg 2000;69:1827-32
10. Kestin AS, Valeri CR, Khuri SF, Loscalzo J, Ellis PA, MacGregor H, Birjiniuk V, Ouimet H, Pasche B, Nelson MJ. The platelet function defect of cardiopulmonary bypass. Blood 1993;82:107-17
11. Valeri CR, Feingold H, Cassidy G, Ragno G, Khuri S, Altschule MD. Hypothermia-induced reversible platelet dysfunction. Ann Surg 1987;205:175-81
12. Michelson AD, MacGregor H, Barnard MR, Kestin AS, Rohrer MJ, Valeri CR. Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. Thromb Haemost 1994;71:633-40
13. Valeri CR, Khabbaz K, Khuri SF, Marquardt C, Ragno G, Feingold H, Gray AD, Axford T. Effect of skin temperature on platelet function in patients undergoing extracorporeal bypass. J Thorac Cardiovasc Surg 1992;104:108-16
14. Straub A, Breuer M, Wendel HP, Peter K, Dietz K, Ziemer G. Critical temperature ranges of hypothermia-induced platelet activation: possible implications for cooling patients in cardiac surgery. Thromb Haemost 2007;97:608-16
15. Tóth O, Calatzis A, Penz S, Losonczy H, Siess W. Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost 2006;96:781-8
16. Vuylsteke A, Sharples L, Charman G, Kneeshaw J, Tsui S, Dunning J, Wheaton E, Klein A, Arrowsmith J, Hall R, Jenkins D. Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery (PEACOG): a randomised controlled trial. Lancet 2011;378:1379-87
17. Thomson B, Tsui SS, Dunning J, Goodwin A, Vuylsteke A, Latimer R, Pepke-Zaba J, Jenkins DP. Pulmonary endarterectomy is possible and effective without the use of complete circulatory arrest: the UK experience in over 150 patients. Eur J Cardiothorac Surg 2008;33:157-63
18. Shimokawa M, Kitaguchi K, Kawaguchi M, Sakamoto T, Kakimoto M, Furuya H. The influence of induced hypothermia for hemostatic function on temperature-adjusted measurements in rabbits. Anesth Analg 2003;96:1209-13
19. Hanke AA, Roberg K, Monaca E, Sellmann T, Weber CF, Rahe-Meyer N, Görlinger K. Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate). Eur J Med Res 2010;15:214-9
20. Stissing T, Dridi NP, Ostrowski SR, Bochsen L, Johansson PI. The influence of low platelet count on whole blood aggregometry assessed by Multiplate. Clin Appl Thromb Hemost 2011;17:E211-7
21. McLaughlin KE, Dunning J. In patients post cardiac surgery do high doses of protamine cause increased bleeding? Interact Cardiovasc Thorac Surg 2003;2:424-6
22. Mochizuki T, Olson PJ, Szlam F, Ramsay JG, Levy JH. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. Anesth Analg 1998;87:781-5
23. Khan NU, Wayne CK, Barker J, Strang T. The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph. Eur J Anaesthesiol 2010;27:624-7
24. Gertler R, Wiesner G, Tassani-Prell P, Braun SL, Martin K. Are the point-of-care diagnostics MULTIPLATE and ROTEM valid in the setting of high concentrations of heparin and its reversal with protamine? J Cardiothorac Vasc Anesth 2011;25:981-6