메뉴 건너뛰기




Volumn 21, Issue 7, 2014, Pages 998-1003

Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression

Author keywords

Aquaporin 4; Blood brain barrier disruption; Ginsenoside Rg1; Neuroprotection; Stroke

Indexed keywords

ACETAZOLAMIDE; AQUAPORIN 4; GINSENOSIDE RG 1; SOYBEAN OIL; AQP4 PROTEIN, RAT; GINSENOSIDE; NEUROPROTECTIVE AGENT;

EID: 84901612797     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.12.005     Document Type: Article
Times cited : (93)

References (33)
  • 2
    • 48849089052 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: Past, present and future
    • M.D. Ginsberg Neuroprotection for ischemic stroke: past, present and future Neuropharmacology 55 2008 363 389
    • (2008) Neuropharmacology , vol.55 , pp. 363-389
    • Ginsberg, M.D.1
  • 4
    • 84863198809 scopus 로고    scopus 로고
    • Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus
    • B. Jiang, Z. Xiong, J. Yang, W. Wang, Y. Wang, Z.L. Hu, F. Wang, and J.G. Chen Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus British Journal of Pharmacology 166 2012 1872 1887
    • (2012) British Journal of Pharmacology , vol.166 , pp. 1872-1887
    • Jiang, B.1    Xiong, Z.2    Yang, J.3    Wang, W.4    Wang, Y.5    Hu, Z.L.6    Wang, F.7    Chen, J.G.8
  • 5
    • 0031596324 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration
    • Y.C. Kim, S.R. Kim, G.J. Markelonis, and T.H. Oh Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration Journal of Neuroscience Research 53 1998 426 432
    • (1998) Journal of Neuroscience Research , vol.53 , pp. 426-432
    • Kim, Y.C.1    Kim, S.R.2    Markelonis, G.J.3    Oh, T.H.4
  • 7
    • 77953307436 scopus 로고    scopus 로고
    • Pharmacology of ginsenosides: A literature review
    • K.W. Leung, and A.S. Wong Pharmacology of ginsenosides: a literature review Chinese Medicine 5 2010 20
    • (2010) Chinese Medicine , vol.5 , pp. 20
    • Leung, K.W.1    Wong, A.S.2
  • 8
    • 80052264023 scopus 로고    scopus 로고
    • Experimental approaches to study functional recovery following cerebral ischemia
    • A. Lipsanen, and J. Jolkkonen Experimental approaches to study functional recovery following cerebral ischemia Cellular and Molecular Life Sciences: CMLS 68 2011 3007 3017
    • (2011) Cellular and Molecular Life Sciences: CMLS , vol.68 , pp. 3007-3017
    • Lipsanen, A.1    Jolkkonen, J.2
  • 9
    • 0037462036 scopus 로고    scopus 로고
    • In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes
    • Z.Q. Liu, X.Y. Luo, G.Z. Liu, Y.P. Chen, Z.C. Wang, and Y.X. Sun In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes Journal of Agricultural and Food Chemistry 51 2003 2555 2558
    • (2003) Journal of Agricultural and Food Chemistry , vol.51 , pp. 2555-2558
    • Liu, Z.Q.1    Luo, X.Y.2    Liu, G.Z.3    Chen, Y.P.4    Wang, Z.C.5    Sun, Y.X.6
  • 11
    • 69149110615 scopus 로고    scopus 로고
    • Ginseng compounds: An update on their molecular mechanisms and medical applications
    • J.M. Lu, Q. Yao, and C. Chen Ginseng compounds: an update on their molecular mechanisms and medical applications Current Vascular Pharmacology 7 2009 293 302
    • (2009) Current Vascular Pharmacology , vol.7 , pp. 293-302
    • Lu, J.M.1    Yao, Q.2    Chen, C.3
  • 12
    • 36849043044 scopus 로고    scopus 로고
    • Ginsenosides: Are any of them candidates for drugs acting on the central nervous system?
    • S.Y. Nah, D.H. Kim, and H. Rhim Ginsenosides: are any of them candidates for drugs acting on the central nervous system? CNS Drug Reviews 13 2007 381 404
    • (2007) CNS Drug Reviews , vol.13 , pp. 381-404
    • Nah, S.Y.1    Kim, D.H.2    Rhim, H.3
  • 14
    • 4644314913 scopus 로고    scopus 로고
    • Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema
    • M.C. Papadopoulos, G.T. Manley, S. Krishna, and A. Verkman Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema The FASEB Journal 18 2004 1291 1293
    • (2004) The FASEB Journal , vol.18 , pp. 1291-1293
    • Papadopoulos, M.C.1    Manley, G.T.2    Krishna, S.3    Verkman, A.4
  • 17
    • 60749114139 scopus 로고    scopus 로고
    • Study on ginsenosides in different parts and ages of Panax quinquefolius L.
    • C. Qu, Y. Bai, X. Jin, Y. Wang, K. Zhang, J. You, and H. Zhang Study on ginsenosides in different parts and ages of Panax quinquefolius L. Food Chemistry 115 2009 340 346
    • (2009) Food Chemistry , vol.115 , pp. 340-346
    • Qu, C.1    Bai, Y.2    Jin, X.3    Wang, Y.4    Zhang, K.5    You, J.6    Zhang, H.7
  • 19
    • 77953686706 scopus 로고    scopus 로고
    • Aquaporin-4 in brain and spinal cord oedema
    • S. Saadoun, and M.C. Papadopoulos Aquaporin-4 in brain and spinal cord oedema Neuroscience 168 2010 1036 1046
    • (2010) Neuroscience , vol.168 , pp. 1036-1046
    • Saadoun, S.1    Papadopoulos, M.C.2
  • 20
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • K.E. Sandoval, and K.A. Witt Blood-brain barrier tight junction permeability and ischemic stroke Neurobiology of Disease 32 2008 200 219
    • (2008) Neurobiology of Disease , vol.32 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2
  • 21
    • 84864513532 scopus 로고    scopus 로고
    • Symptomatic intracranial hemorrhage following intravenous thrombolysis for acute ischemic stroke: A critical review of case definitions
    • R.C. Seet, and A.A. Rabinstein Symptomatic intracranial hemorrhage following intravenous thrombolysis for acute ischemic stroke: a critical review of case definitions Cerebrovascular Diseases (Basel, Switzerland) 34 2012 106 114
    • (2012) Cerebrovascular Diseases (Basel, Switzerland) , vol.34 , pp. 106-114
    • Seet, R.C.1    Rabinstein, A.A.2
  • 22
    • 34249072490 scopus 로고    scopus 로고
    • NMDA receptor and iNOS are involved in the effects of ginsenoside Rg1 on hippocampal neurogenesis in ischemic gerbils
    • L. Shen, and J. Zhang NMDA receptor and iNOS are involved in the effects of ginsenoside Rg1 on hippocampal neurogenesis in ischemic gerbils Neurological Research 29 2007 270 273
    • (2007) Neurological Research , vol.29 , pp. 270-273
    • Shen, L.1    Zhang, J.2
  • 23
    • 0034575228 scopus 로고    scopus 로고
    • Extracts of Ginkgo biloba and Panax ginseng protect brain proteins from free radical induced oxidative damage in vitro
    • M.S. Siddique, F. Eddeb, D. Mantle, and A.D. Mendelow Extracts of Ginkgo biloba and Panax ginseng protect brain proteins from free radical induced oxidative damage in vitro Acta Neurochirurgica Supplement 76 2000 87 90
    • (2000) Acta Neurochirurgica Supplement , vol.76 , pp. 87-90
    • Siddique, M.S.1    Eddeb, F.2    Mantle, D.3    Mendelow, A.D.4
  • 24
    • 33846245504 scopus 로고    scopus 로고
    • Preventing stroke: Saving lives around the world
    • K. Strong, C. Mathers, and R. Bonita Preventing stroke: saving lives around the world Lancet Neurology 6 2007 182 187
    • (2007) Lancet Neurology , vol.6 , pp. 182-187
    • Strong, K.1    Mathers, C.2    Bonita, R.3
  • 25
    • 79551666188 scopus 로고    scopus 로고
    • Targeting hypoxia inducible factor-1alpha: A novel mechanism of ginsenoside Rg1 for brain repair after hypoxia/ischemia brain damage
    • B. Tang, Y. Qu, D. Wang, and D. Mu Targeting hypoxia inducible factor-1alpha: a novel mechanism of ginsenoside Rg1 for brain repair after hypoxia/ischemia brain damage CNS & Neurological Disorders Drug Targets 10 2011 235 238
    • (2011) CNS & Neurological Disorders Drug Targets , vol.10 , pp. 235-238
    • Tang, B.1    Qu, Y.2    Wang, D.3    Mu, D.4
  • 26
  • 27
    • 64549087639 scopus 로고    scopus 로고
    • 20(S)-ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain
    • J. Tian, S. Zhang, G. Li, Z. Liu, and B. Xu 20(S)-ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain Phytotherapy Research 23 2009 486 491
    • (2009) Phytotherapy Research , vol.23 , pp. 486-491
    • Tian, J.1    Zhang, S.2    Li, G.3    Liu, Z.4    Xu, B.5
  • 28
    • 79961209219 scopus 로고    scopus 로고
    • Stroke declines from third to fourth leading cause of death in the United States: Historical perspective and challenges ahead
    • A. Towfighi, and J.L. Saver Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead Stroke; A Journal of Cerebral Circulation 42 2011 2351 2355
    • (2011) Stroke; A Journal of Cerebral Circulation , vol.42 , pp. 2351-2355
    • Towfighi, A.1    Saver, J.L.2
  • 29
    • 79960025353 scopus 로고    scopus 로고
    • Ginsen-oside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice
    • R. Ye, X. Kong, Q. Yang, Y. Zhang, J. Han, and G. Zhao Ginsen-oside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice Neuropharmacology 61 2011 815 824
    • (2011) Neuropharmacology , vol.61 , pp. 815-824
    • Ye, R.1    Kong, X.2    Yang, Q.3    Zhang, Y.4    Han, J.5    Zhao, G.6
  • 31
    • 43549126841 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects neurons from hypoxic-ischemic injury possibly by inhibiting Ca2+ influx through NMDA receptors and L-type voltage-dependent Ca2+ channels
    • Y.F. Zhang, X.J. Fan, X. Li, L.L. Peng, G.H. Wang, K.F. Ke, and Z.L. Jiang Ginsenoside Rg1 protects neurons from hypoxic-ischemic injury possibly by inhibiting Ca2+ influx through NMDA receptors and L-type voltage-dependent Ca2+ channels European Journal of Pharmacology 586 2008 90 99
    • (2008) European Journal of Pharmacology , vol.586 , pp. 90-99
    • Zhang, Y.F.1    Fan, X.J.2    Li, X.3    Peng, L.L.4    Wang, G.H.5    Ke, K.F.6    Jiang, Z.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.