Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig

Journal of Inflammation Research

Volumn 3, Issue 1, 2010, Pages 9-16

  Medicherla, Satyanarayana ^a   Ma, Jing Ying ^a   Reddy, Mamtha ^a   Esikova, Irina ^a   Kerr, Irene ^a   Movius, Fabiola ^a   Higgins, Linda S ^a   Protter, Andrew A ^a  

^a SCIOS INC   (United States)

Author keywords

Myeloperoxidase; Neutrophils; Phosphorylated p38; SCIO 469; Skin; Topical

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MYELOPEROXIDASE; SCIO 469;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GUINEA PIG; NEUTROPHIL CHEMOTAXIS; NONHUMAN; REPRODUCIBILITY; SKIN INFLAMMATION;

EID: 77953416219     PISSN: None     EISSN: 11787031     Source Type: Book Series    
DOI: None     Document Type: Article

References (31)

1. Roosterman D, Goerge T, Schneider SW, Bunnett NW, Steinhoff M. Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev. 2006;86:1309-1379.
2. Beissert S, Cavazzana I, Mascia F, et al. Mechanisms of immunemediated skin diseases: an overview. Clin Exp Rheumatol. 2006; 24:1-6.
3. Lebwohl M. A clinician's paradigm in the treatment of psoriasis. J Am Acad Dermatol. 2005;53:59-69.
4. Heyer G, Koppert W, Martus P, Handwerker HO. Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria. Acta Derm Venereol. 1998;78: 123-126.
5. Zelickson BD, Muller SA. Generalized pustular psoriasis. A review of 63 cases. Arch Dermatol. 1991;127:1339-1345.
6. Terui T, Ozawa M, Tagami H. Role of neutrophils in induction of acute inflammation in T-cell mediated immune dermatosis, psoriasis: a neutrophilassociated inflammation-boosting loop. Exp Dermatol. 2000;9:1-10.
7. Tay YK, Tham SN. The profile and outcome of pustular psoriasis in Singapore: a report of 28 cases. Int J Dermatol. 1997;36:266-271.
8. Langtry JA, Carr MM, Ive FA, Gordon P, Hunter JA, Harper JI. Ichthyosiform erythroderma associated with generalized pustulosis. Br J Dermatol. 1998;138:502-505.
9. Hildesheim J, Awad RT, Fornace AJ. p38 mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory response. J Invest Dermatol. 2004;122:497-502.
10. Takanami-Ohnishi Y, Amano S, Kimura S, et al. Essential role of p38 mitogen activate protein kinase in contact hypersensitivity. J Biol Chem. 2002;277:37896-37903.
11. Kim AL, Labasi JM, Zhu Y, et al. Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol. 2005;124:1318-1325.
12. Ipaktchi K, Mattar A, Niederbichler AD, et al. Topical p38 MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds. Shock. 2006;26:201-209.
13. Ottosen ER, Sorensen MD, Bjorkling F, et al. Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAPK kinase inhibitors with high anti-inflammatory activity. J Med Chem. 2003;46:5651-5662.
14. Valiveti S, Hammell DC, Farles DC, Stinchcomb AL. In vitro/in vivo correlation studies for transdermal delta 8-THC development. J Pharm Sci. 2004;93:1154-1164.
15. Aronson PJ. A review of the role of neutrophils in psoriasis and related disorders. Dermatol Online J. 2008;14:7.
16. Cruz MT, Duarte CB, Goncalo M, Carvalho AP, Lopes MC. Involvement of JAK2 and MAPK on type II nitric oxide synthaase expression in skin-derived dendritic cells. Am J Physiol. 1999;277: 1050-1057.
17. Bochkov VN, Kadl A, Huber J, Gruber F, Binder BR, Leitinger N. Protective role of phospholipids oxidation products in endotoxin-induced tissue damage. Nature. 2002;419:77-81.
18. Marleau S, Laclos FB, Sanchez AB, Poubelle PE, Borgeat P, Marleau S. Role of 5-lipoxygenase products in the local accumulation of neutrophils in dermal inflammation in the rabbit. J Immunol. 1999;163:3449-3458.
19. Kim H, Koh G. Lipopolysaccharide activates matrix metalloproteinase-2 in endothelial cells through an NF-kappaB-dependent pathway. Biochem Biophys Res Commun. 2000;269:401-405.
20. Landmann R, Scherer F, Schumann R, Link S, Sansano S, Zimmerli W. LPS directly induces oxygen radical production in human monocytes via LPS binding protein and CD14. J Leukoc Biol. 1995;57:440-449.
21. Frey EA, Finlay BB. Lipopolysaccharide induces apoptosis in a bovine endothelial cell line via a soluble CD14 dependent pathway. Microb Pathog. 1998;24:101-110.
22. Dominquez C, Powers DA, Tamayo NO. p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discoy Devel. 2005;4:421-430.
23. Cottrell J, Meyenhofer, Medicherla S, Higgings LS, O'Connor JP. Analgesic effects of p38 kinase inhibitor treatment on bone fracture healing. Pain. 2009;142:116-126.
24. Medicherla S, Protter AA, Ma JY, et al. Preventive andterapeutical potential of p38 alpha-selective mitogen-activated protein kinase inhibi-tor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006;318:99-107.
25. Medicherla S, Ma JY, Mangadu R, et al. A selective p38 alpha mitogen activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen induced arthritis. J Pharmacol Exptl Ther. 2006;318:132-141.
26. Kumar S, McDonnell PC, Gum RJ, Hand AT. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997;235:533-538.
27. Richards HL, Ray DW, Kirby B, et al. Response of the hypothalamicpituitary-adrenal axis to psychological stress in patients with psoriasis. Br J Dermatol. 2005;153:1114-1120.
28. Herlin T, Kragballe K. Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis. Br J Dermatol. 1981;105:405-413.
29. Ikoma A, Fartasch M, Heyer G, Miyachi Y, Handwerker HO, Schmelz M. Painful stimuli evoke itch in patients with chronic pruritus; central sensitizatioin for itch. Neurology. 2004;62:212-217.
30. Sweitzer SM, Peters MC, Ma JY, et al. Peripheral and central p38 MAPK mediates capsaicin induced hyperalgesia. Pain. 2004;111:278-285.
31. Funding AT, Johansen C, Kragballe K, et al. Mitogen and stress-activated protein kinase 1 is activated in lesional epidermis and regulates the expression of proinflammatory cytokines. J Invest Dermatol. 2006;126:1784-1791.