The roles of aquaporin-4 in brain edema following neonatal hypoxia ischemia and reoxygenation in a cultured rat astrocyte model

GLIA

Volumn 55, Issue 9, 2007, Pages 935-941

  Fu, Xuemei ^a,b   Li, Qiuping ^a   Feng, Zhichun ^b   Mu, Dezhi ^c  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Aquaporin 4; Astrocytes; Edema; Hypoxia ischemia; Neonate

Indexed keywords

AQUAPORIN 4; MESSENGER RNA; SMALL INTERFERING RNA; WATER;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN EDEMA; BRAIN HYPOXIA; BRAIN ISCHEMIA; CELL CULTURE; CELL VOLUME; CONTROLLED STUDY; DISEASE COURSE; DRUG INHIBITION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REOXYGENATION; RNA INTERFERENCE; WATER TRANSPORT; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; AQUAPORIN 4; ASPHYXIA NEONATORUM; ASTROCYTES; BRAIN; BRAIN EDEMA; CELL MEMBRANE PERMEABILITY; CELL SIZE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA INTERFERENCE; WATER-ELECTROLYTE BALANCE;

EID: 34250169470     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20515     Document Type: Article

References (18)

1. Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A. 2003. An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci USA 100:2106-2111.
2. Amiry-Moghaddam M, Xue R, Haug FM, Neely JD, Bhardwaj A, Agre P, Adams ME, Froehner SC, Mori S, Ottersen OP. 2004. α-Syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J 18:542-544.
3. Badaut J, Lasbennes F, Magistretti PJ, Regli L. 2002. Aquaporins in brain: Distribution, physiology and pathophysiology. J Cereb Blood Flow Metab 22:367-378.
4. Chan H, Butterworth RF, Hazell AS. 2004. Primary cultures of rat astrocytes respond to thiamine deficiency-induced swelling by down-regulating aquaporin-4 levels. Neurosci Lett 366:231-234.
5. Frigeri A, Nicchia GP, Nico B, Quondamatteo F, Herken R, Roncali L, Svelto M. 2001. Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx mice. FASEB J 15:90-98.
6. Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P. 1994. Molecular characterization of an aquaporin cDNA from brain: Candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci USA 91:13052-13056.
7. Klatzo I. 1967. Presidential address. Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 26:1-14.
8. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. 2000. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159-163.
9. Meng S, Qiao M, Lin L, Del Bigio MR, Tomanek B, Tuor UI. 2004. Correspondence of AQP4 expression and hypoxic-ischaemic brain oedema monitored by magnetic resonance imaging in the immature and juvenile rat. Eur J Neurosci 19:2261-2269.
10. Nicchia GP, Frigeri A, Liuzzi GM, Santacroce MP, Nico B, Procino G, Quondamatteo F, Herken R, Roncali L, Svelto M. 2000. Aquaporin-4-containing astrocytes sustain a temperature- and mercury-insensitive swelling in vitro. Glia 31:29-38.
11. Papadopoulos MC, Krishna S, Verkman AS. 2002. Aquaporin water channels and brain edema. Mt Sinai J Med 69:242-248.
12. Papadopoulos MC, Verkman AS. 2005. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem 280:13906-13912.
13. Plate KH, Warnke PC. 1997. Vascular endothelial growth factor. J Neurooncol 35:365-372.
14. Rash JE, Yasumura T, Hudson CS, Agre P, Nielsen S. 1998. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc Natl Acad Sci USA 95:11981-11986.
15. Tomas-Camardiel M, Venero JL, Herrera AJ, De Pablos RM, Pintor-Toro JA, Machado A, Cano J. 2005. Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: Protective effect by estradiol treatment in ovariectomized animals. J Neurosci Res 80:235-246.
16. Vajda Z, Pedersen M, Fuchtbauer EM, Wertz K, Stodkilde-Jorgensen H, Sulyok E, Doczi T, Neely JD, Agre P, Frokiaer J, Nielsen S. 2002. Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc Natl Acad Sci USA 99:13131-13136.
17. Wang H, Yao Y, Jiang X, Chen D, Xiong Y, Mu D. 2006. Expression of Nogo-A and NgR in the developing rat brain after hypoxia-ischemia. Brain Res 1114:212-220.
18. Yamamoto N, Yoneda K, Asai K, Sobue K, Tada T, Fujita Y, Katsuya H, Fujita M, Aihara N, Mase M, Yamada K, Miura Y, Kato T. 2001. Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation. Brain Res Mol Brain Res 20:26-38.