-
1
-
-
84999145040
-
Guidance for industry diabetes mellitus — evaluating cardio vascular risk in new antidiabetic therapies to treat type 2 diabetes
-
Available online at:
-
[1] U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Guidance for industry diabetes mellitus — evaluating cardio vascular risk in new antidiabetic therapies to treat type 2 diabetes. 2008 Available online at: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071627.pdf.
-
(2008)
-
-
-
2
-
-
84937516238
-
Oral hypoglycemic agents and the heart failure conundrum: lessons from and for outcome trials
-
[2] Kappel, B.A., Marx, N., Federici, M., Oral hypoglycemic agents and the heart failure conundrum: lessons from and for outcome trials. Nutr Metab Cardiovasc Dis 25 (2015), 697–705.
-
(2015)
Nutr Metab Cardiovasc Dis
, vol.25
, pp. 697-705
-
-
Kappel, B.A.1
Marx, N.2
Federici, M.3
-
3
-
-
84978427983
-
Novel antidiabetic drugs and CR: primum non nocere
-
[3] Bonadonna, R.C., Borghi, C., Consoli, A., Volpe, M., Novel antidiabetic drugs and CR: primum non nocere. Nutr Metab Cardiovasc Dis 26 (2016), 759–766.
-
(2016)
Nutr Metab Cardiovasc Dis
, vol.26
, pp. 759-766
-
-
Bonadonna, R.C.1
Borghi, C.2
Consoli, A.3
Volpe, M.4
-
4
-
-
84990987678
-
Current cardiovascular outcomes trials in type 2 diabetes: perspectives and insight
-
[4] Coch, R.W., Green, J.B., Current cardiovascular outcomes trials in type 2 diabetes: perspectives and insight. Nutr Metab Cardiovasc Dis 26 (2016), 767–772.
-
(2016)
Nutr Metab Cardiovasc Dis
, vol.26
, pp. 767-772
-
-
Coch, R.W.1
Green, J.B.2
-
5
-
-
84944800184
-
EMPA-REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
[5] Zinman, B., Wanner, C., Lachin, J.M., Fitchett, D., Bluhmki, E., Hantel, S., et al. EMPA-REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373 (2015), 2117–2128.
-
(2015)
N Engl J Med
, vol.373
, pp. 2117-2128
-
-
Zinman, B.1
Wanner, C.2
Lachin, J.M.3
Fitchett, D.4
Bluhmki, E.5
Hantel, S.6
-
7
-
-
84964507777
-
SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?
-
[7] Sattar, N., McLaren, J., Kristensen, S.L., Preiss, D., McMurray, J.J., SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?. Diabetologia 59 (2016), 1333–1339.
-
(2016)
Diabetologia
, vol.59
, pp. 1333-1339
-
-
Sattar, N.1
McLaren, J.2
Kristensen, S.L.3
Preiss, D.4
McMurray, J.J.5
-
8
-
-
84999207619
-
-
[8] http://www.ema.europa.eu/docs/en_GB/document_library/EPAR-Public_assessment_report/human/002677/WC500168594.pdf.
-
-
-
-
9
-
-
84958548824
-
Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis
-
[9] Sonesson, C., Johansson, P.A., Johnsson, E., Gause-Nilsson, I., Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis. Cardiovasc Diabetol, 15, 2016, 37.
-
(2016)
Cardiovasc Diabetol
, vol.15
, pp. 37
-
-
Sonesson, C.1
Johansson, P.A.2
Johnsson, E.3
Gause-Nilsson, I.4
-
10
-
-
84999237875
-
-
[10] http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002322/WC500136024.pdf.
-
-
-
-
11
-
-
84999193139
-
-
[11] http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002649/WC500156457.pdf.
-
-
-
-
12
-
-
84999114508
-
-
[12] http://www.clinicaltrials.gov.
-
-
-
-
13
-
-
68349130799
-
Prevention of cardiovascular disease through glycemic control in type 2 diabetes: a meta-analysis of randomized clinical trials
-
[13] Mannucci, E., Monami, M., Lamanna, C., Gori, F., Marchionni, N., Prevention of cardiovascular disease through glycemic control in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 19 (2009), 604–612.
-
(2009)
Nutr Metab Cardiovasc Dis
, vol.19
, pp. 604-612
-
-
Mannucci, E.1
Monami, M.2
Lamanna, C.3
Gori, F.4
Marchionni, N.5
-
14
-
-
67349251550
-
Megatrials in type 2 diabetes. From excitement to frustration?
-
[14] Del Prato, S., Megatrials in type 2 diabetes. From excitement to frustration?. Diabetologia 52 (2009), 1219–1226.
-
(2009)
Diabetologia
, vol.52
, pp. 1219-1226
-
-
Del Prato, S.1
-
15
-
-
70449364536
-
Prediction of coronary heart disease risk in a general, pre-diabetic, and diabetic population during 10 years of follow-up: accuracy of the Framingham, SCORE, and UKPDS risk functions: the Hoorn Study
-
[15] van der Heijden, A.A., Ortegon, M.M., Niessen, L.W., Nijpels, G., Dekker, J.M., Prediction of coronary heart disease risk in a general, pre-diabetic, and diabetic population during 10 years of follow-up: accuracy of the Framingham, SCORE, and UKPDS risk functions: the Hoorn Study. Diabetes Care 32 (2009), 2094–2098.
-
(2009)
Diabetes Care
, vol.32
, pp. 2094-2098
-
-
van der Heijden, A.A.1
Ortegon, M.M.2
Niessen, L.W.3
Nijpels, G.4
Dekker, J.M.5
-
16
-
-
84928196614
-
EMPA-REG BP Investigators. Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension
-
[16] Tikkanen, I., Narko, K., Zeller, C., Green, A., Salsali, A., Broedl, U.C., et al. EMPA-REG BP Investigators. Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension. Diabetes Care 38 (2015), 420–428.
-
(2015)
Diabetes Care
, vol.38
, pp. 420-428
-
-
Tikkanen, I.1
Narko, K.2
Zeller, C.3
Green, A.4
Salsali, A.5
Broedl, U.C.6
-
17
-
-
84945455839
-
Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
-
[17] Chilton, R., Tikkanen, I., Cannon, C.P., Crowe, S., Woerle, H.J., Broedl, U.C., et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 17 (2015), 1180–1193.
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 1180-1193
-
-
Chilton, R.1
Tikkanen, I.2
Cannon, C.P.3
Crowe, S.4
Woerle, H.J.5
Broedl, U.C.6
-
18
-
-
84882251091
-
Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis
-
[18] Vasilakou, D., Karagiannis, T., Athanasiadou, E., Mainou, M., Liakos, A., Bekiari, E., et al. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med 159 (2013), 262–274.
-
(2013)
Ann Intern Med
, vol.159
, pp. 262-274
-
-
Vasilakou, D.1
Karagiannis, T.2
Athanasiadou, E.3
Mainou, M.4
Liakos, A.5
Bekiari, E.6
-
19
-
-
0032511580
-
Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
-
[19] UK Prospective Diabetes Study Group, Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 317 (1998), 703–713.
-
(1998)
BMJ
, vol.317
, pp. 703-713
-
-
UK Prospective Diabetes Study Group1
-
20
-
-
0035212615
-
United Kingdom Prospective Diabetes Study (UKPDS) Group. The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56)
-
[20] Stevens, R.J., Kothari, V., Adler, A.I., Stratton, I.M., United Kingdom Prospective Diabetes Study (UKPDS) Group. The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56). Clin Sci (Lond) 101 (2001), 671–679.
-
(2001)
Clin Sci (Lond)
, vol.101
, pp. 671-679
-
-
Stevens, R.J.1
Kothari, V.2
Adler, A.I.3
Stratton, I.M.4
-
21
-
-
84923448295
-
SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials
-
[21] Inzucchi, S.E., Zinman, B., Wanner, C., Ferrari, R., Fitchett, D., Hantel, S., et al. SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials. Diab Vasc Dis Res 12 (2015), 90–100.
-
(2015)
Diab Vasc Dis Res
, vol.12
, pp. 90-100
-
-
Inzucchi, S.E.1
Zinman, B.2
Wanner, C.3
Ferrari, R.4
Fitchett, D.5
Hantel, S.6
-
22
-
-
27644457743
-
Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
-
[22] Yusuf, S., Hawken, S., Ounpuu, S., Bautista, L., Franzosi, M.G., Commerford, P., et al., INTERHEART Study Investigators. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 366 (2005), 1640–1649.
-
(2005)
Lancet
, vol.366
, pp. 1640-1649
-
-
Yusuf, S.1
Hawken, S.2
Ounpuu, S.3
Bautista, L.4
Franzosi, M.G.5
Commerford, P.6
-
24
-
-
84924812509
-
The impact of diabetes-related complications on healthcare costs: new results from the UKPDS (UKPDS 84)
-
[24] Alva, M.L., Gray, A., Mihaylova, B., Leal, J., Holman, R.R., The impact of diabetes-related complications on healthcare costs: new results from the UKPDS (UKPDS 84). Diabet Med 32 (2015), 459–466.
-
(2015)
Diabet Med
, vol.32
, pp. 459-466
-
-
Alva, M.L.1
Gray, A.2
Mihaylova, B.3
Leal, J.4
Holman, R.R.5
-
25
-
-
26244453309
-
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone Clinical Trial in macroVascular Events): a randomised controlled trial
-
[25] Dormandy, J.A., Charbonnel, B., Eckland, D.J., Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone Clinical Trial in macroVascular Events): a randomised controlled trial. Lancet 366 (2005), 1279–1289.
-
(2005)
Lancet
, vol.366
, pp. 1279-1289
-
-
Dormandy, J.A.1
Charbonnel, B.2
Eckland, D.J.3
-
26
-
-
84883765959
-
SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
-
[26] Scirica, B.M., Bhatt, D.L., Braunwald, E., Steg, P.G., Davidson, J., Hirshberg, B., et al. SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 369 (2013), 1317–1326.
-
(2013)
N Engl J Med
, vol.369
, pp. 1317-1326
-
-
Scirica, B.M.1
Bhatt, D.L.2
Braunwald, E.3
Steg, P.G.4
Davidson, J.5
Hirshberg, B.6
-
27
-
-
84883745765
-
Alogliptin after acute coronary syndrome in patients with type 2 diabetes
-
[27] White, W.B., Cannon, C.P., Heller, S.R., Nissen, S.E., Bergenstal, R.M., Bakris, G.L., et al., EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 369 (2013), 1327–1335.
-
(2013)
N Engl J Med
, vol.369
, pp. 1327-1335
-
-
White, W.B.1
Cannon, C.P.2
Heller, S.R.3
Nissen, S.E.4
Bergenstal, R.M.5
Bakris, G.L.6
-
28
-
-
84930085787
-
Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
-
[28] Zannad, F., Cannon, C.P., Cushman, W.C., Bakris, G.L., Menon, V., Perez, A.T., et al., EXAMINE Investigators. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet 385 (2015), 2067–2076.
-
(2015)
Lancet
, vol.385
, pp. 2067-2076
-
-
Zannad, F.1
Cannon, C.P.2
Cushman, W.C.3
Bakris, G.L.4
Menon, V.5
Perez, A.T.6
-
29
-
-
84937053742
-
Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes
-
[29] Green, J.B., Bethel, M.A., Armstrong, P.W., Buse, J.B., Engel, S.S., Garg, J., et al., TECOS Study Group. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 373 (2015), 232–242.
-
(2015)
N Engl J Med
, vol.373
, pp. 232-242
-
-
Green, J.B.1
Bethel, M.A.2
Armstrong, P.W.3
Buse, J.B.4
Engel, S.S.5
Garg, J.6
-
30
-
-
84941739763
-
Direct effects of DPP-4 inhibition on the vasculature. Reconciling basic evidence with lack of clinical evidence
-
[30] Fadini, G.P., Albiero, M., Avogaro, A., Direct effects of DPP-4 inhibition on the vasculature. Reconciling basic evidence with lack of clinical evidence. Vasc Pharmacol 73 (2015), 1–3.
-
(2015)
Vasc Pharmacol
, vol.73
, pp. 1-3
-
-
Fadini, G.P.1
Albiero, M.2
Avogaro, A.3
-
31
-
-
0037132607
-
Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT-LLT)
-
[31] Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT-LLT). JAMA, 288, 2002.
-
(2002)
JAMA
, vol.288
-
-
-
32
-
-
84964608804
-
Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
-
[32] Ferrannini, E., Baldi, S., Frascerra, S., Astiarraga, B., Heise, T., Bizzotto, R., et al. Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes. Diabetes 65 (2016), 1190–1195.
-
(2016)
Diabetes
, vol.65
, pp. 1190-1195
-
-
Ferrannini, E.1
Baldi, S.2
Frascerra, S.3
Astiarraga, B.4
Heise, T.5
Bizzotto, R.6
-
33
-
-
84939142605
-
Rother KI.SGLT2i may predispose to ketoacidosis
-
[33] Taylor, S.I., Blau, J.E., Rother KI.SGLT2i may predispose to ketoacidosis. J Clin Endocrinol Metab 100 (2015), 2849–2852.
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. 2849-2852
-
-
Taylor, S.I.1
Blau, J.E.2
-
34
-
-
84962339296
-
Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition
-
[34] Peters, A.L., Buschur, E.O., Buse, J.B., Cohan, P., Diner, J.C., Hirsch, I.B., Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care 38 (2015), 1687–1693.
-
(2015)
Diabetes Care
, vol.38
, pp. 1687-1693
-
-
Peters, A.L.1
Buschur, E.O.2
Buse, J.B.3
Cohan, P.4
Diner, J.C.5
Hirsch, I.B.6
-
35
-
-
0029008947
-
Insulin, ketone bodies, and mitochondrial energy transduction
-
[35] Sato, K., Kashiwaya, Y., Keon, C.A., Tsuchiya, N., King, M.T., Radda, G.K., et al. Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J 9 (1995), 651–658.
-
(1995)
FASEB J
, vol.9
, pp. 651-658
-
-
Sato, K.1
Kashiwaya, Y.2
Keon, C.A.3
Tsuchiya, N.4
King, M.T.5
Radda, G.K.6
-
36
-
-
84919342453
-
Effects of high vs low glycemic index of dietary carbohydrate on cardiovascular disease risk factors and insulin sensitivity: the OmniCarb randomized clinical trial
-
Dec 17
-
[36] Sacks, F.M., Carey, V.J., Anderson, C.A., Miller, E.R. 3rd, Copeland, T., Charleston, J., et al. Effects of high vs low glycemic index of dietary carbohydrate on cardiovascular disease risk factors and insulin sensitivity: the OmniCarb randomized clinical trial. JAMA 312:23 (2014 Dec 17), 2531–2541.
-
(2014)
JAMA
, vol.312
, Issue.23
, pp. 2531-2541
-
-
Sacks, F.M.1
Carey, V.J.2
Anderson, C.A.3
Miller, E.R.4
Copeland, T.5
Charleston, J.6
-
37
-
-
84957709696
-
Sodium-glucose cotransporter inhibitors: effects on renal and intestinal glucose transport: from bench to bedside
-
[37] Mudaliar, S., Polidori, D., Zambrowicz, B., Henry, R.R., Sodium-glucose cotransporter inhibitors: effects on renal and intestinal glucose transport: from bench to bedside. Diabetes Care 38 (2015), 2344–2353.
-
(2015)
Diabetes Care
, vol.38
, pp. 2344-2353
-
-
Mudaliar, S.1
Polidori, D.2
Zambrowicz, B.3
Henry, R.R.4
-
38
-
-
0024429924
-
Ridge KM.Mechanism of angiotensin II stimulation of Na-K-Cl cotransport of vascular smooth muscle cells
-
[38] Owen, N.E., Ridge KM.Mechanism of angiotensin II stimulation of Na-K-Cl cotransport of vascular smooth muscle cells. Am J Physiol 257 (1989), C629–C636.
-
(1989)
Am J Physiol
, vol.257
, pp. C629-C636
-
-
Owen, N.E.1
-
39
-
-
77953857048
-
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial
-
[39] Bailey, C.J., Gross, J.L., Pieters, A., Bastien, A., List, J.F., Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 375 (2010), 2223–2233.
-
(2010)
Lancet
, vol.375
, pp. 2223-2233
-
-
Bailey, C.J.1
Gross, J.L.2
Pieters, A.3
Bastien, A.4
List, J.F.5
-
40
-
-
84991521037
-
Intracellular Na+ concentration ([Na+]i) is elevated in diabetic hearts due to enhanced Na+-Glucose cotransport
-
[40] Lambert, R., Srodulski, S., Peng, X., Margulies, K.B., Despa, F., Despa, S., Intracellular Na+ concentration ([Na+]i) is elevated in diabetic hearts due to enhanced Na+-Glucose cotransport. J Am Heart Assoc, 4, 2015, e002183.
-
(2015)
J Am Heart Assoc
, vol.4
, pp. e002183
-
-
Lambert, R.1
Srodulski, S.2
Peng, X.3
Margulies, K.B.4
Despa, F.5
Despa, S.6
-
41
-
-
84880850027
-
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
-
[41] Heerspink HJ1, Lambers, de Zeeuw, D., Wie, L., Leslie, B., List, J., Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 15 (2013), 853–862.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 853-862
-
-
Heerspink HJ1, L.1
de Zeeuw, D.2
Wie, L.3
Leslie, B.4
List, J.5
-
42
-
-
84969141912
-
The effects of erythropoiesis stimulating therapy for anemia in chronic heart failure: a meta-analysis of randomized clinical trials
-
[42] Kang, J., Park, J., Lee, J.M., Park, J.J., Choi, D.J., The effects of erythropoiesis stimulating therapy for anemia in chronic heart failure: a meta-analysis of randomized clinical trials. Int J Cardiol 218 (2016), 12–22.
-
(2016)
Int J Cardiol
, vol.218
, pp. 12-22
-
-
Kang, J.1
Park, J.2
Lee, J.M.3
Park, J.J.4
Choi, D.J.5
-
43
-
-
84893872877
-
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
-
[43] Ferrannini, E., Muscelli, E., Frascerra, S., Baldi, S., Mari, A., Heise, T., et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest 124 (2014), 499–508.
-
(2014)
J Clin Invest
, vol.124
, pp. 499-508
-
-
Ferrannini, E.1
Muscelli, E.2
Frascerra, S.3
Baldi, S.4
Mari, A.5
Heise, T.6
-
44
-
-
84937763347
-
Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
-
[44] Bonner, C., Kerr-Conte, J., Gmyr, V., Queniat, G., Moerman, E., Thévenet, J., et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med 21 (2015), 512–517.
-
(2015)
Nat Med
, vol.21
, pp. 512-517
-
-
Bonner, C.1
Kerr-Conte, J.2
Gmyr, V.3
Queniat, G.4
Moerman, E.5
Thévenet, J.6
-
45
-
-
84921892213
-
Myocardiocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction
-
[45] Ali, S., Ussher, J.R., Baggio, L.L., Kabir, M.G., Charron, M.J., Ilkayeva, O., et al. Myocardiocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction. Mol Metab 4 (2014), 132–143.
-
(2014)
Mol Metab
, vol.4
, pp. 132-143
-
-
Ali, S.1
Ussher, J.R.2
Baggio, L.L.3
Kabir, M.G.4
Charron, M.J.5
Ilkayeva, O.6
-
46
-
-
0025270818
-
Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase
-
Wilkerson RD, Partlow DB, Pruett JK, Patterson CW. A possible mechanism of the antiarrhythmic action of glucagon. Eur J Pharmacol. 1977;44:57-63
-
[46] Méry, P.F., Brechler, V., Pavoine, C., Pecker, F., Fischmeister, R., Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase. Nature 345 (1990), 158–161 Wilkerson RD, Partlow DB, Pruett JK, Patterson CW. A possible mechanism of the antiarrhythmic action of glucagon. Eur J Pharmacol. 1977;44:57-63.
-
(1990)
Nature
, vol.345
, pp. 158-161
-
-
Méry, P.F.1
Brechler, V.2
Pavoine, C.3
Pecker, F.4
Fischmeister, R.5
-
47
-
-
0017685308
-
A possible mechanism of the antiarrhythmic action of glucagon
-
[47] Wilkerson, R.D., Partlow, D.B., Pruett, J.K., Patterson, C.W., A possible mechanism of the antiarrhythmic action of glucagon. Eur J Pharmacol 44 (1977), 57–63.
-
(1977)
Eur J Pharmacol
, vol.44
, pp. 57-63
-
-
Wilkerson, R.D.1
Partlow, D.B.2
Pruett, J.K.3
Patterson, C.W.4
-
48
-
-
84947904354
-
Understanding EMPA-REG OUTCOME
-
[48] Ceriello, A., Genovese, S., Mannucci, E., Gronda, E., Understanding EMPA-REG OUTCOME. Lancet Diabetes Endocrinol 3 (2015), 929–930.
-
(2015)
Lancet Diabetes Endocrinol
, vol.3
, pp. 929-930
-
-
Ceriello, A.1
Genovese, S.2
Mannucci, E.3
Gronda, E.4
-
49
-
-
84911896573
-
Liraglutide and the preservation of pancreatic β-cell function in early type 2 diabetes: the LIBRA trial
-
[49] Retnakaran, R., Kramer, C.K., Choi, H., Swaminathan, B., Zinman, B., Liraglutide and the preservation of pancreatic β-cell function in early type 2 diabetes: the LIBRA trial. Diabetes Care 37 (2014), 3270–3278.
-
(2014)
Diabetes Care
, vol.37
, pp. 3270-3278
-
-
Retnakaran, R.1
Kramer, C.K.2
Choi, H.3
Swaminathan, B.4
Zinman, B.5
-
50
-
-
84978839381
-
Liraglutide and cardiovascular outcomes in type 2 diabetes
-
[50] Marso, S.P., Daniels, G.H., Brown-Frandsen, K., Kristensen, P., Mann, J.F., Nauck, M.A., et al., LEADER Steering Committee on behalf of the LEADER Trial Investigators. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375:4 (2016), 311–322.
-
(2016)
N Engl J Med
, vol.375
, Issue.4
, pp. 311-322
-
-
Marso, S.P.1
Daniels, G.H.2
Brown-Frandsen, K.3
Kristensen, P.4
Mann, J.F.5
Nauck, M.A.6
-
51
-
-
0037636471
-
The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction
-
[51] Schmaier, A.H., The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction. Am J Physiol Regul Integr Comp Physiol 285 (2003), R1–R13.
-
(2003)
Am J Physiol Regul Integr Comp Physiol
, vol.285
, pp. R1-R13
-
-
Schmaier, A.H.1
-
52
-
-
84947998534
-
Understanding EMPA-REG OUTCOME
-
[52] Muskiet, M.H., van Raalte, D.H., van Bommel, E.J., Smits, M.M., Tonneijck, L., Understanding EMPA-REG OUTCOME. Lancet Diabetes Endocrinol 3 (2015), 928–929.
-
(2015)
Lancet Diabetes Endocrinol
, vol.3
, pp. 928-929
-
-
Muskiet, M.H.1
van Raalte, D.H.2
van Bommel, E.J.3
Smits, M.M.4
Tonneijck, L.5
-
53
-
-
0141640818
-
Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1)
-
[53] Zhou, L., Cryan, E.V., D'Andrea, M.R., Belkowski, S., Conway, B.R., Demarest, K.T., Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1). J Cell Biochem 90 (2003), 339–346.
-
(2003)
J Cell Biochem
, vol.90
, pp. 339-346
-
-
Zhou, L.1
Cryan, E.V.2
D'Andrea, M.R.3
Belkowski, S.4
Conway, B.R.5
Demarest, K.T.6
-
54
-
-
84943234625
-
Localizations of Na[+]-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart
-
[54] Vrhovac, I., Balen Eror, D., Klessen, D., Burger, C., Breljak, D., Kraus, O., et al. Localizations of Na[+]-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart. Pflugers Arch 467 (2015), 1881–1898.
-
(2015)
Pflugers Arch
, vol.467
, pp. 1881-1898
-
-
Vrhovac, I.1
Balen Eror, D.2
Klessen, D.3
Burger, C.4
Breljak, D.5
Kraus, O.6
-
55
-
-
70449729537
-
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states
-
[55] Banerjee, S.K., McGaffin, K.R., Pastor-Soler, N.M., Ahmad, F., SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. Cardiovasc Res 84 (2009), 111–118.
-
(2009)
Cardiovasc Res
, vol.84
, pp. 111-118
-
-
Banerjee, S.K.1
McGaffin, K.R.2
Pastor-Soler, N.M.3
Ahmad, F.4
-
56
-
-
84861938337
-
GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle
-
[56] Aerni-Flessner, L., Abi-Jaoude, M., Koenig, A., Payne, M., Hruz, P.W., GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovasc Diabetol, 11, 2012, 63.
-
(2012)
Cardiovasc Diabetol
, vol.11
, pp. 63
-
-
Aerni-Flessner, L.1
Abi-Jaoude, M.2
Koenig, A.3
Payne, M.4
Hruz, P.W.5
-
57
-
-
78149279712
-
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
-
[57] Russell, R.R. 3rd, Li, J., Coven, D.L., Pypaert, M., Zechner, C., Palmeri, M., et al. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 114 (2004), 495–503.
-
(2004)
J Clin Invest
, vol.114
, pp. 495-503
-
-
Russell, R.R.1
Li, J.2
Coven, D.L.3
Pypaert, M.4
Zechner, C.5
Palmeri, M.6
-
58
-
-
0036167225
-
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
-
[58] Arad, M., Benson, D.W., Perez-Atayde, A.R., McKenna, W.J., Sparks, E.A., Kanter, R.J., et al. Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J Clin Invest 109 (2002), 357–362.
-
(2002)
J Clin Invest
, vol.109
, pp. 357-362
-
-
Arad, M.1
Benson, D.W.2
Perez-Atayde, A.R.3
McKenna, W.J.4
Sparks, E.A.5
Kanter, R.J.6
-
59
-
-
84921312956
-
Transgenic knockdown of cardiac sodium/glucose cotransporter 1 (SGLT1) attenuates PRKAG2 cardiomyopathy, whereas transgenic overexpression of cardiac SGLT1 causes pathologic hypertrophy and dysfunction in mice
-
pii: e000899
-
[59] Ramratnam, M., Sharma, R.K., D'Auria, S., Jung Lee, S., Wang, D., Yin, N.X.H., et al. Transgenic knockdown of cardiac sodium/glucose cotransporter 1 (SGLT1) attenuates PRKAG2 cardiomyopathy, whereas transgenic overexpression of cardiac SGLT1 causes pathologic hypertrophy and dysfunction in mice. J Am Heart Assoc, 3, 2014 pii: e000899.
-
(2014)
J Am Heart Assoc
, vol.3
-
-
Ramratnam, M.1
Sharma, R.K.2
D'Auria, S.3
Jung Lee, S.4
Wang, D.5
Yin, N.X.H.6
-
60
-
-
56349152651
-
Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium
-
[60] von Lewinski, D., Kockskämper, J., Rübertus, S.U., Zhu, D., Schmitto, J.D., Schöndube, F.A., et al. Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium. Eur J Heart Fail 10 (2008), 1172–1176.
-
(2008)
Eur J Heart Fail
, vol.10
, pp. 1172-1176
-
-
von Lewinski, D.1
Kockskämper, J.2
Rübertus, S.U.3
Zhu, D.4
Schmitto, J.D.5
Schöndube, F.A.6
-
61
-
-
80054122252
-
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1
-
[61] Balteau, M., Tajeddine, N., de Meester, C., Ginion, A., Des Rosiers, C., Brady, N.R., et al. NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovasc Res 92 (2011), 237–246.
-
(2011)
Cardiovasc Res
, vol.92
, pp. 237-246
-
-
Balteau, M.1
Tajeddine, N.2
de Meester, C.3
Ginion, A.4
Des Rosiers, C.5
Brady, N.R.6
-
62
-
-
83655184724
-
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
-
[62] Grempler, R., Thomas, L., Eckhardt, M., Himmelsbach, F., Sauer, A., Sharp, D.E., et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab 14 (2012), 83–90.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 83-90
-
-
Grempler, R.1
Thomas, L.2
Eckhardt, M.3
Himmelsbach, F.4
Sauer, A.5
Sharp, D.E.6
-
63
-
-
84878947970
-
Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes
-
[63] Heise, T., Seewaldt-Becker, E., Macha, S., Hantel, S., Pinnetti, S., Seman, L., et al. Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes. Diabetes Obes Metab 15 (2013), 613–621.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 613-621
-
-
Heise, T.1
Seewaldt-Becker, E.2
Macha, S.3
Hantel, S.4
Pinnetti, S.5
Seman, L.6
-
64
-
-
84923502372
-
Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy
-
[64] Rosenstock, J., Cefalu, W.T., Lapuerta, P., Zambrowicz, B., Ogbaa, I., Banks, P., et al. Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy. Diabetes Care 38 (2015), 431–438.
-
(2015)
Diabetes Care
, vol.38
, pp. 431-438
-
-
Rosenstock, J.1
Cefalu, W.T.2
Lapuerta, P.3
Zambrowicz, B.4
Ogbaa, I.5
Banks, P.6
-
65
-
-
84876519168
-
LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose
-
[65] Powell, D.R., Smith, M., Greer, J., Harris, A., Zhao, S., DaCosta, C., et al. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose. J Pharmacol Exp Ther 345 (2013), 250–259.
-
(2013)
J Pharmacol Exp Ther
, vol.345
, pp. 250-259
-
-
Powell, D.R.1
Smith, M.2
Greer, J.3
Harris, A.4
Zhao, S.5
DaCosta, C.6
-
66
-
-
84864270406
-
Basal insulin and cardiovascular and other outcomes in dysglycemia
-
[66] Trial Investigators, O.R.I.G.I.N., Gerstein, H.C., Bosch, J., Dagenais, G.R., Díaz, R., Jung, H., et al. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 367 (2012), 319–328.
-
(2012)
N Engl J Med
, vol.367
, pp. 319-328
-
-
Trial Investigators, O.R.I.G.I.N.1
Gerstein, H.C.2
Bosch, J.3
Dagenais, G.R.4
Díaz, R.5
Jung, H.6
-
67
-
-
84948740668
-
ELIXA Investigators. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
-
[67] Pfeffer, M.A., Claggett, B., Diaz, R., Dickstein, K., Gerstein, H.C., Køber, L.V., et al. ELIXA Investigators. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373 (2015), 2247–2257.
-
(2015)
N Engl J Med
, vol.373
, pp. 2247-2257
-
-
Pfeffer, M.A.1
Claggett, B.2
Diaz, R.3
Dickstein, K.4
Gerstein, H.C.5
Køber, L.V.6
|